This course is intended for statistics or biostatistics students interested in methods for the design and analysis of epidemiology studies.
Statistics 642 Spring 2007 Course Materials
Syllabus
Lecture 1
Lectures for Chapter 2, Volume 1
Lecture Handout #3
Lecture 4 Handout
Lecture Handout 5, Chapter 5, Breslow and Day
Chapter 6, Volume 1, Lecture Notes
Lecture Notes: Chapter 7, Breslow and Day, Volume 1
Lecture Handout, Chapter 2, Volume 2, Breslow and Day
Lecture Handout, Chapter 3, Volume 2, Breslow and Day
Lecture Handout, Chapter 4, Volume 2, Breslow and Day
Montana Smelter Worker Data
Documentation for Montana Smelter Worker Data
Lecture Handout, Chapter 5, Volume 2, Breslow and Day
Homework 5: Welsh Nickel Data
Homework 5: Welsh Nickel Data Documentation
Lecture Handout: Chapter 7, Breslow and Day, Volume 2
Lecture Handout: Longitudinal Data Analysis
Course Description:
This course will cover statistical methods for design, conduct, and analysis of epidemiologic studies such
as case-control and cohort studies. Topics include overview of designs for research studies; epidemiologic
study design; rates and risk; measures of association; classical contingency table methods; logistic and
Poisson regression; and proportional hazard regression. Examples from the literature and data from a
number of well-known epidemiologic studies will be used for illustration of the concepts involved.
Additional topics will be discussed time permitting at the end of the semester.
Topics include:
- Epidemiologic Study Design
- Analysis of Case-Control Studies
- Measure of Association
- Classical Methods for 2x2 Tables
- Conditional and Unconditional Logistic Regression
- Analysis of Cohort Studies
- Rates, Standardized Rates, SMR
- Poisson Regression
- Longitudinal Data
Prerequisite:
STAT 609 and 610 or equivalent strongly recommended, but not required.
Course Requirements:
A series of homework assignment will be given throughout the course. These assignments will be graded
and counted toward the final course grade. There will be one each of in-class or take-home mid-term and
final examinations.
Schedule: T/TH 9:30-10:45 PM
Location: 133 SMI (note change from originally scheduled room)
Course Text and Materials:
Lectures will be primarily drawn from Breslow and Day, Statistical Methods in Cancer Research: Volume
I, “The Analysis of Case-Control Studies” and Volume II, “The Design and Analysis of Cohort Studies”.
Volume I is available at the bookstore and is strongly recommended; handouts from the text will not be
provided. Volume II is out of print; handouts of the text will be provided for relevant lectures. Other
texts available at the bookstore are encouraged and will be helpful in understanding the statistical
methodology, but are not required. Copies of journal articles on historically important epidemiologic
studies and statistical methods will also be made available, as needed.
Course materials not distributed in class will be available in the statistics 642 directory on the following
URL: http://www.biostat.wisc.edu/People/faculty/fine.htm
- Statistical Methods in Cancer Research: Volume I - The Analysis of Case-Control Studies. N. Breslow and N. Day, I.A.R.C., Lyon (1980).
- Statistical Methods in Cancer Research: Volume II - The Design and Analysis of Cohort Studies. N. Breslow and N. Day, I.A.R.C., Lyon (1987).
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