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Karl Broman

Professor, Department of Biostatistics & Medical Informatics

PhD, 1997, University of California, Berkeley

Office: 2126 Genetics/Biotechnology
Phone: 608-262-4633
FAX: 608-265-7916
Mailing address:

6770 Medical Sciences Center
1300 University Avenue
Madison, WI 53706-1532

Karl Broman's webpage
  Research Interests
Dr. Broman's research concerns statistical problems in genetics, genomics, and molecular biology.
He is particularly interested in the development of improved methods for detecting and identifying genes contributing to variation in complex traits in humans and experimental organisms.
  Selected Publications

Broman KW, Sen Ś (2009) A Guide to QTL Mapping with R/qtl. Springer, New York

Broman KW, Kim S, Sen S, Ane C, Payseur BA (2012) Mapping quantitative trait loci onto a phylogenetic tree. Genetics 192:267-279

Neto EC, Keller MP, Broman AF, Attie AD, Jansen RC, Broman KW, Yandell BS (2012) Quantile-based permutation thresholds for quantitative trait loci hotspots. Genetics 191:1355-1365

King EG, Merkes CM, McNeil CL, Hoofer SR, Sen S, Broman KW, Long AD, Macdonald SJ (2012) Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource. Genome Res 22:1558-1566

Arends D, van der Velde KJ, Prins P, Broman KW, Möller S, Jansen RC, Swertz MA (2012) xQTL workbench: a web based environment for xQTL analysis. Bioinformatics 28:1042-1044

Broman KW (2012) Genotype probabilities at intermediate generations in the construction of recombinant inbred lines. Genetics 190:403-412

Broman KW (2012) Haplotype probabilities in advanced intercross populations. G3 2:199-202

Aylor DL, et al. (2011) Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res 21: 1213-1222

Arends D, Prins P, Jansen RC, Broman KW (2010) R/qtl: High-throughput multiple QTL mapping. Bioinformatics 26:2990-2992

Manichaikul A, Moon JY, Sen Ś, Yandell BS, Broman KW (2009) A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis. Genetics 181:1077-1086

Broman KW, Wu H, Sen Ś, Churchill GA (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics 19:889-890

Broman KW, Matsumoto N, Giglio S, Martin CL, Roseberry JA, Zuffardi O, Ledbetter DH, Weber JL (2003) Common long human inversion polymorphism on chromosome 8p. In: Goldstein DR (ed) Science and Statistics: A Festschrift for Terry Speed. IMS Lecture Notes-Monograph Series, Vol 40, pp 237-245

Broman KW, Speed TP (2002) A model selection approach for the identification of quantitative trait loci in experimental crosses (with discussion). J Roy Stat Soc B 64:641-656, 731-775

Broman KW, Rowe LB, Churchill GA, Paigen K (2002) Crossover interference in the mouse. Genetics 160:1123-1131

Broman KW, Weber JL (2000) Characterization of human crossover interference. Am J Hum Genet 66:1911-1926

Broman KW, Weber JL (1999) Long homozygous chromosomal segments in reference families from the Centre d'Étude du Polymorphisme Humain. Am J Hum Genet 65:1493-1500

Broman KW, Murray JC, Sheffield VC, White RL, Weber JL (1998) Comprehensive human genetic maps: Individual and sex-specific variation in recombination. Am J Hum Genet 63:861-869

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