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Karl Broman


Professor, Department of Biostatistics & Medical Informatics

PhD, 1997, University of California, Berkeley

Office: 4710 Medical Sciences Center (MSC)
 
Phone: 608-262-4633
FAX: 608-265-7916
Email:
 
Mailing address:

6770 Medical Sciences Center
1300 University Avenue
Madison, WI 53706-1532

Karl Broman's webpage

 

 
  Research Interests

 

Dr. Broman's research concerns statistical problems in genetics, genomics, and molecular biology.
He is particularly interested in the development of improved methods for detecting and identifying genes contributing to variation in complex traits in humans and experimental organisms.
  Selected Publications

 

Broman KW, Sen Ś (2009) A Guide to QTL Mapping with R/qtl. Springer, New York

Murdoch B, Owen N, Shirley S, Crumb S, Broman KW, Hassold T (2010) Multiple loci contribute to genome-wide recombination levels in male mice. Mamm Genome 21:550-555

Billings T, Sargent EE, Szatkiewicz JP, Leahy N, Kwak, I-Y, Bektassova N, Walker M, Hassold T, Graber JH, Broman KW, Petkov PM (2010) Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping. PLoS One 5:e15340

Arends D, Prins P, Jansen RC, Broman KW (2010) R/qtl: High-throughput multiple QTL mapping. Bioinformatics 26:2990-2992

Burrage LC, Baskin-Hill AE, Sinasac DS, Singer JB, Croniger CM, Kirby A, Kulbokas EJ, Daly MJ, Lander ES, Broman KW, Nadeau JH (2010) Genetic resistance to diet-induced obesity in chromosome substitution strains of mice. Mamm Genome 21:115-129

Cheng EY, Hunt PA, Naluai-Cecchini TA, Fligner CL, Fujimoto VY, Pasternack TL, Schwartz JM, Steinauer JE, Woodruff TJ, Cherry SM, Hansen TA, Vallente RU, Broman KW, Hassold TJ (2009) Meiotic recombination in human oocytes. PLoS Genet 5:e1000661

Fledel-Alon A, Wilson DJ, Broman K, Wen X, Ober C, Coop G, Przeworski M (2009) Broad-scale recombination patterns underlying proper disjunctions in humans. PLoS Genet 5:e1000658

Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih S-W, Churchill GA, Broman KW (2009) A new standard genetic map for the laboratory mouse. Genetics 182:1335-1344

Dumont BL, Broman KW, Payseur BA (2009) Variation in genomic recombination rates among heterogeneous stock mice. Genetics 182:1345-1349

Manichaikul A, Broman KW (2009) Binary trait mapping in experimental crosses with selective genotyping. Genetics 182:863-874

Manichaikul A, Moon JY, Sen Ś, Yandell BS, Broman KW (2009) A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis. Genetics 181:1077-1086

Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O'Brien W, Courtland HW, Jepsen KJ, Kirby A, Kulbokas EJ, Daly MJ, Broman KW, Lander ES, Nadeau JH (2008) Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci USA 105:19910-19914

Broman KW, Wu H, Sen Ś, Churchill GA (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics 19:889-890

Broman KW, Matsumoto N, Giglio S, Martin CL, Roseberry JA, Zuffardi O, Ledbetter DH, Weber JL (2003) Common long human inversion polymorphism on chromosome 8p. In: Goldstein DR (ed) Science and Statistics: A Festschrift for Terry Speed. IMS Lecture Notes-Monograph Series, Vol 40, pp 237-245

Broman KW, Speed TP (2002) A model selection approach for the identification of quantitative trait loci in experimental crosses (with discussion). J Roy Stat Soc B 64:641-656, 731-775

Broman KW, Rowe LB, Churchill GA, Paigen K (2002) Crossover interference in the mouse. Genetics 160:1123-1131

Broman KW, Weber JL (2000) Characterization of human crossover interference. Am J Hum Genet 66:1911-1926

Broman KW, Weber JL (1999) Long homozygous chromosomal segments in reference families from the Centre d'Étude du Polymorphisme Humain. Am J Hum Genet 65:1493-1500

Broman KW, Murray JC, Sheffield VC, White RL, Weber JL (1998) Comprehensive human genetic maps: Individual and sex-specific variation in recombination. Am J Hum Genet 63:861-869

   
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