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General Departmental Seminar Series


Epidemiology of Cystic Fibrosis - Opportunities for Biostatistical Applications and Research

Hui-Chuan Lai, Ph.D., R.D., Department of Nutritional Sciences, UW-Madison

Friday, Jan 31, 2003, 12-1 p.m.

Room 6225, Medical Sciences Center, 1300 University Ave.

ABSTRACT

Cystic fibrosis (CF) is one of the most common, life-threatening genetic diseases, affecting 30,000 children and adults in the United States. CF causes the body to produce abnormally thick, sticky mucus, due to the faulty transport of sodium and chloride (salt) across cells. The thick CF mucus obstructs the ducts and disrupts normal functions of many organs, including the pancreas and the lungs, resulting in malnutrition and lung disease.

With the advances in the diagnosis and treatment of CF in the past several decades, the life expectancy of patients with CF has increased dramatically from 6 months since it was first described in 1938 to 33 years in 2000. The availability of good quality population databases in the last decade has provided new opportunities, as well as challenges to apply and develop biostatistical methods to study the progression of this disease.

This presentation will give an overview of the disease CF, a description of the population datasets, followed by discussions of the various statistical approaches (e.g., longitudinal analysis, time-to-event analysis, multivariate analysis, etc) that may be utilized to quantify disease progression.


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