UW Biiostatistics & Medical Informatics UW Biostatistics & Medical Informatics UW Madison UW Biostatistics & Medical Informatics Site Map
UW School of Medicine and Public Health UW Madison



General Departmental Seminar Series

Brent Logan, PhD
Associate Professor Division of Biostatistics
Department of Population Health Medical College of Wisconsin

Friday, January 23rd, 2009
12:00 pm - 1:00 pm
5275 MSC

Marginal models for clustered time to event data with competing risks using pseudo-values

Many time-to-event studies are complicated by the presence of competing risks and by nesting of individuals within a cluster, such as patients in the same center in a multi-center study. Several methods have been proposed for modeling the cumulative incidence function with independent observations. However, when subjects are clustered, one needs to account for the presence of a cluster effect either through frailty modeling of the hazard or subdistribution hazard, or by adjusting for the within-cluster correlation in a marginal model.

We propose a method for modeling the marginal cumulative incidence function directly. We compute leave one out pseudo-observations from the cumulative incidence function at several time points. These are used in a generalized estimating equation to model the marginal cumulative incidence curve, and obtain consistent estimates of the model parameters. A sandwich variance estimate is derived to adjust for the within cluster correlation. The method is easy to implement using standard software once the pseudo-values are obtained, and is a generalization of several existing models. Simulation studies show that the method has good operating characteristics. We illustrate the method on a dataset looking at outcomes after bone marrow transplantation.

Return to seminar list


Internal Use | Site Map | Search |
Overview | People | Training | Research | Seminars | Employment | Links |
Biostatistics Program | Clinical Trials Program | Medical Informatics Program | Biomedical Computing |

Copyright © 2009 The Board of Regents of the
University of Wisconsin System


UW Madison UW School of Medicine and Public Health