University of Wisconsin, Madison, Biostatistics and Medical Informatics

Karl Broman

Associate Professor,
Department of Biostatistics & Medical Informatics

Ph.D., 1997, University of California, Berkeley

Offices	6763 Medical Sciences Center (MSC)
	1274 Genetics-Biotechnology Center
Phones	608-262-4633 (MSC)
	608-263-0549 (Biotechnology)
FAX	608-265-7916
Email	kbroman at biostat dot wisc dot edu
Mailing address Box 1532, 6770 Medical Sciences Center 1300 University Avenue Madison, WI 53706-1532
Karl Broman's webpage

Research Interests

Dr. Broman's research concerns statistical problems in genetics, genomics, and molecular biology. He is particularly interested in the development of improved methods for detecting and identifying genes contributing to variation in complex traits in humans and experimental organisms.

Selected Publications

Teuscher F, Broman KW (2007) Haplotype probabilities for multiple-strain recombinant inbred lines. Genetics 175:1267-1274

Broman KW, Sen Ś, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA (2006) The X chromosome in quantitative trait locus mapping. Genetics 174:2151-2158

Manichaikul A, Dupuis J, Sen Ś, Broman KW (2006) Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus. Genetics 174:481-489

Feenstra B, Skovgaard IM, Broman KW (2006) Mapping quantitative trait loci by an extension of the Haley-Knott regression method using estimating equations. Genetics 173:2269-228

Broman KW (2005) Mapping expression in randomized rodent genomes. Nat Genet 37:209-210

Broman KW (2005) The genomes of recombinant inbred lines. Genetics 169:1133-1146

The Complex Trait Consortium (2004) The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 36:1133-1137

Broman KW, Feingold E (2004) SNPs made routine. Nat Methods 1:104-105

Broman KW, Wu H, Sen Ś, Churchill GA (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics 19:889-890

Broman KW, Matsumoto N, Giglio S, Martin CL, Roseberry JA, Zuffardi O, Ledbetter DH, Weber JL (2003) Common long human inversion polymorphism on chromosome 8p. In: Goldstein DR (ed) Science and Statistics: A Festschrift for Terry Speed. IMS Lecture Notes-Monograph Series, Vol 40, pp 237-245

Broman KW, Speed TP (2002) A model selection approach for the identification of quantitative trait loci in experimental crosses (with discussion). J Roy Stat Soc B 64:641-656, 731-775

Broman KW, Rowe LB, Churchill GA, Paigen K (2002) Crossover interference in the mouse. Genetics 160:1123-1131

Broman KW, Weber JL (2000) Characterization of human crossover interference. Am J Hum Genet 66:1911-1926

Broman KW, Weber JL (1999) Long homozygous chromosomal segments in reference families from the Centre d'Étude du Polymorphisme Humain. Am J Hum Genet 65:1493-1500

Broman KW, Murray JC, Sheffield VC, White RL, Weber JL (1998) Comprehensive human genetic maps: Individual and sex-specific variation in recombination. Am J Hum Genet 63:861-869