Wittke-Thompson JK, Pluzhnikov A, Cox NJ (2005) Rational inferences about departures from Hardy-Weinberg equilibrium. American Journal of Human Genetics 76:967-986, Figure 1

What's wrong with this one?

If you want your graph to be published in large format, it seems that the American Journal of Human Genetics is the place to which you should aim. This figure spans two pages. Panel D is most interesting; it takes a while to identify that there is any information there at all.

What should have been done?

Figure 1D could have been discarded completely, and the whole figure shouldn't take up more than half a page.