Lindstrom, Mary J.

Mary J. Lindstrom
Professor, Department of Biostatistics & Medical Informatics
Room & Building: 
H6/548 CSC

lindstro [at]

Education & Research: 

PhD, 1987, University of Wisconsin-Madison

Research Interests
Functional data analysis, semiparametric models, nonlinear random effects models, free knot spline regression, analysis of clustered data, statistical computing.

Detailed Description

My research concentrates on methods for functional data analysis, that is, the analysis of data where the ideal observation for each experimental unit is a function. Since it is not possible to observe the entire function, the data for each experimental unit consist of a number of noisy observations of the function at various points in its domain. I am interested in methods for modeling such data including parametric and semi-parametric nonlinear random effects models. Free knot splines are of interest as a nonparametric model for the unknown functions. Estimation for these models is often computationally intensive and appropriate statistical computing methods are essential. My collaborative research involves the development of functional data analysis methods for laboratory research in radiation oncology and the multivariate time series data produced by the micro-beam project at the Waisman Center.

Selected Publications
Lindstrom, M., & Bates, D. (1988). Newton-Raphson and EM algorithms for linear mixed effects models for repeated measures data. Journal of the American Statistical Association, 83,1014 1022.

Lindstrom, M., & Bates, D. (1990). Nonlinear mixed effects models for repeated measures data. Biometrics, 46, 673-687.

Lindstrom, M., & Fowler, J. (1991). Re-analysis of the time factor in local control by radiotherapy of T3T4 squamous cell carcinoma of the larynx. International Journal of Radiation Oncology, Biology, and Physics, 21, 813-817.

Fowler, J., & Lindstrom, M. (1992). Loss of local control with prolongation in radiotherapy. International Journal of Radiation Oncology, Biology and Physics, 23, 457-467.

Haag, J., Lindstrom, M., & Gould, M. (1992). Limonene-induced regression of mammary carcinomas. Cancer Research, 52, 4021-4026.

Kollmar, R., Lindstrom, M., & Farnham, P. (1992). Heat sensitivity and Sp1 activation of complex formation at the Syrian hamster CAD promoter. Journal of Biological Chemistry, 267, 385-391.

Ritter, M., Fowler, J., Kim, Y., Lindstrom, M., & Kinsella, T. (1992). Single biopsy tumor kinetic analysis: A comparison of methods and an extension to shorter sampling times. International Journal of Radiation Oncology, Biology, and Physics, 23, 811-820.

Albertini, M., Howard, S., Fisch, P., Lindstrom, M., Hank, J., Gould, M., et al. (1993). Modulation of target cell culture conditions alters susceptibility to lymphocyte-mediated lysis. Journal of Immunotherapy, 13, 243-251.

Lindstrom, M., Kunugi, K., & Kinsella, T. (1993). Global comparison of radiation and chemotherapy dose-response curves with a test for interaction. Radiation Research, 135, 269-277.

Lindstrom, M. (1995). Self modeling with random scale and shift parameters and a free-knot spline shape function. Statistics in Medicine, 14, 2009-2021.

Schultz, C., Gaffney, D., Lindstrom, M., & Kinsella, T. (1995). Iododeoxyuridine Radiosensitization of human glioblastoma cells exposed to acute and chronic gamma irradiation: mechanistic implications and clinical relevance. The Cancer Journal, 1, 151-161.

Pendergast, J., Gange, S., Lindstrom, M., Newton, M., Palta, M., & Fisher, M. (1996). A survey of methods for analyzing clustered binary data. International Statistical Review, 64, 89-118.

Surfus, J., Hank, J., Oosterwijk, E., Welt, S., Lindstrom, M., Albertini, M., et al. (1996). Anti-renal cell carcinoma chimeric antibody G250 facilitates antibody dependent cellular cytotoxicity with in vitro and in vivo interleukin-2 activated effectors. Journal of Immunotherapy, 19, 184-191.

Kuo, M., Kunugi, K., Lindstrom, M., & Kinsella, T. (1997). The interaction of hydroxyurea and ionizing radiation in human cervical carcinoma cells. The Cancer Journal from Scientific American, 3,163-171.

Pendergast, J., Gange, S., & Lindstrom, M. (1997). Correlated binary data. Encyclopedia of Biostatistics. New York: Wiley.

Hill, C., Nelms, B., Mackay, J., Pearson, D., Kennan, W., Mackie, T., et al. (1998). Synchrotron-produced ultrasoft x-rays: Equivalent cell survival at the isoattenuating energies 273eV and 860eV. Radiation Research, 150, 513-520.

Nelms, B., Mackie, T., Mackay, J., Hill, C., DeLuca, P., Lindstrom, M., et al. (1998). A comparison of cytotoxicity following whole vs. partial cell irradiation with synchrotron-produced ultrasoft x-rays. Radiation Research, 150, 521-527.

Stoesz, S., Friedl, A., Haag, J., Lindstrom, M., Clark, G., & Gould, M. (1998). Heterogeneous expression of the lipocalin NGAL in primary breast cancers. International Journal of Cancer, 79, 565-572.

Westbury, J., Hashi, M., & Lindstrom, M. (1998). Differences among speakers in lingual articulation for American English. Speech Communication, 26, 203-226.

Wilkerson, C., Darjatmoko, S., Lindstrom, M., & Albert, D. (1998). Toxicity and dose response studies of 1,25(OH)2-16-ENE-23-YNE Vitamin D3 in transgenic mice. Clinical Cancer Research, 4, 2253-2256.

Lindstrom, M. (1999). Penalized estimation of free-knot splines. Journal of Computational and Graphical Statistics, 8, 333-352.

Ladd, W., & Lindstrom, M. (2000). Self modeling for two-dimensional response curves. Biometrics, 56, 89-97.

Westbury, J., Severson, E., & Lindstrom, M. (2000). Kinematic event patterns in speech: Special problems. Language and Speech, 43, 403-428.

Bates, D., Lindstrom, M., & Wahba, G. (2001). Comments on ‘Semi-parametric nonlinear mixed effects models and their application' by C. Kei and Y. Wang. Journal of the American Statistical Association, 96, 456.

Lindstrom, M. (2001). Comments on ‘Flexible regression modeling with adaptive logistic basis functions’ by P. M. Hooper. Canadian Journal of Statistics, 29, 343--378.

Albert, D., Nickells, R., Gamm, D., Zimbric, M., Schlamp, C., Lindstrom, M., et al. (2002). Vitamin D analogs, a new treatment for retinoblastoma: The first Ellsworth Lecture. Ophthalmic Genetics, 23,137-156.

Kim, K., Lindstrom, M., & Gould, M. (2002). Regions of H- and K-Ras which encode organ specificity and potency in mammary cancer induction. Cancer Research, 62,1241--1245.

Lindstrom, M. (2002). Comments on ‘Spline adaptation in extended linear models’ by Mark H. Hanson and Charles Kooperberg. Statistical Science, 17, 32-33.

Dawson, D., Gleiser, J., Zimbric, M., Darjatmoko, S., Frisbie, J., Lokken, J., et al. (2002). Toxicity and dose-response studies of 1-alpha-Hydroxy vitamin D2 in LH-beta-TAG transgenic mice. Ophthalmology, 100, 125-129.

Lindstrom, M. (2002). Bayesian estimation of free-knot splines using reversible jumps. Computational Statistics and Data Analysis, 41, 255-269.

McFarlin, D., Lindstrom, M., & Gould, M. (2003). Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas. Carcinogenesis, 24, 99-105.

Westbury, J., McClean, M., &, Lindstrom, M. (2002). Tongues and lips without jaws: Some consequences of ignoring jaw rotation. Journal of Speech, Language and Hearing Research. 45(4):651--662.

Lindstrom, M., & Kotz, S. (under review). Free-knot Splines. In S. Kotz, N. Johnson, & C. Read (Eds.), Encyclopedia of Statistics. New York: Wiley.

Audo, I., Darjatmoko, S.R., Schlamp, C.L., Lokken, J.M., Lindstrom, M.J.,Albert, D.M., Nickells, R.W.: Vitamin D analogs Increase p53, p21, and Apoptosis in a Xenograft Model of Human Retinoblastoma. Investigative Ophthalmology and Visual Sciences, 44:4192--4199, 2003.

Brumback, L.C. and lindstrom, M.J. (2004). Self Modeling with Flexible,Random Time Transformations. Biometrics, to appear June 2004.

Dickerson, E.B., Akhtar, N., Steinberg H., Wang, Z., Lindstrom, M.J., Padilla, M.L., Auerbach, R. and Helfand, S.C. (2004) Enhancement of the antiangiogenic activity of interleukin-12 by peptide targeted delivery of the cytokine to alpha v beta 3 integrin. Molecular Cancer Research 2:663-673.

Vorperian, H.K., Kent, R.D., Lindstrom M.J., Kalina, C.M., Gentry, L.R., Yandell, B.S. (2005) Development of vocal tract length during early childhood: A magnetic resonance imaging study. Journal of the Acoustical Society of America 117:338-350.

Kofler, J.M., Lindstrom, M.J., Kelcz, F., Madsen, E.L. (2005): Association of Automated and Human Observer Lesion Detecting Ability Using Ultrasound. Ultrasound in Medicine and Biology.

Ariazi J.L., Haag, J.D., Lindstrom, M.J., and Gould, M.N.: Mammary glands of sexually immature rats are more susceptible than those of mature rats to the carcinogenic, lethal, and mutagenic effects of N-nitroso-N-methylurea. Carcinogenesis, To Appear.

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Courses Taught
Statistics 371 (Introductory Applied Statistics for the Life Sciences) - Spring 2004


Functional data analysis, semi-parametric models, nonlinear random effects models, free knot spline regression, analysis of clustered data, statistical computing.