Faculty and students from numerous departments meet monthly to discuss papers from the human genetics literature, with a particular focus on the genetic dissection of complex diseases.
If you would like to suggest an article for discussion, email Corinne Engelman, cengelman at wisc.edu
| Past meetings | 10 Apr 2015, 3:00pm, 1205 Microbial Sciences | |
| Aschard et al. (2015)
Adjusting for heritable covariates can bias effect
estimates in genome-wide association studies. Am J Hum Genet 96:329-339 [pdf | PubMed | At journal] | ||
| 6 Mar 2015, 3:00pm, 1205 Microbial Sciences | ||
| Johnston et al. (2015) Population
genetics identifies challenges in analyzing rare variants. Genet
Epidemiol, to appear
[pdf] | ||
| 25 Apr 2014, 3:00pm, 1419 WARF | ||
| Charles et al. (2014) Accounting for
linkage disequlibirium in association analysis of diverse
populations. Genet Epidemiol 38:265-273
[pdf | PubMed | At journal] | ||
| 21 Mar 2014, 3:00pm, 1419 WARF | ||
| Plomin et al. (2013) Common
DNA markers can account for more than half of the genetic influence
on cognitive abilities. Psychol Sci 24:562-568
[pdf | PubMed | At journal] | ||
| 21 Feb 2014, 3:00pm, 1419 WARF | ||
| Pan et al. (2014) A system-level pathway-phenotype
association analysis using synthetic feature random forest. Genet
Epidemiol, in press [pdf | At journal] | ||
| 11 Oct 2013, 3:00pm, 1205A Microbial Sciences | ||
| Khurana et al. (2013) Integrative annotation of variants from 1092 humans: Application to cancer genomics. Sci
ence 342:1235587 [PubMed | pdf (with supplement) | At journal] | ||
| 19 Apr 2013, 3:30pm, 1205A Microbial Sciences | ||
| Ma et al. (2013) Gene-based testing of interactions in association studies of quantitative traits. PLoS Genet 9:e1003321
[PubMed | pdf | At journal | Supporting information (zip)] | ||
| 15 Mar 2013, 3:30pm, 1205A Microbial Sciences | ||
| Main paper: | Manolio et al. (2013) Implementing genomic medicine in the clinic: the future is here. Genetics in Medicine, in press [PubMed | pdf | At journal] | |
| Commentary: | Evans and Khoury (2013) The arrival of genomic medicine to the clinic is only the beginning of the journey. Genetics in Medicine, in press [PubMed | pdf | At journal] | |
| 15 Feb 2013, 3:30pm, 1205A Microbial Sciences | ||
| Vimaleswaran et al. (2013) Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Medicine 10:e1001383 [PubMed | pdf | At journal] | ||
| 14 Dec 2012, 3:30pm, 3503 Microbial Sciences | ||
| Main paper: | Tzoulaki et al. (2012) A nutrient-wide association study on blood pressure. Circulation 126:2456-2464 [PubMed | pdf | At journal] | |
| Related: | Scientific American article | |
| 16 Nov 2012, 3:30pm, 1205A Microbial Sciences | ||
| Main paper: | Li et al. (2012) Inflammatory Bowel Diseases phenotype, C. difficile and
NOD2 genotype are associated with shifts in human ileum associated microbial composition. PLoSONE 7:e26284 [PubMed | pdf | At journal | Supplement (pdf)] | |
| Related: |
Human Microbiome Project Economist article New Yorker article New York Times article | |
| 19 Oct 2012, 3:30pm, 1205A Microbial Sciences | ||
| Tennessen et al. (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337:64-69 [PubMed | pdf | At journal | Supplement (pdf)] | ||
| 21 Sept 2012, 3:30pm, 1205A Microbial Sciences | ||
| ENCODE Project Consortium (2012) An integrated encyclopedia of DNA elements in the human genome. Nature 489:57-74 [PubMed | pdf | At journal] | ||
| 11 May 2012, 3pm, 6201 Microbial Sciences | ||
| Sanders et al. (2012) De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature, to appear [PubMed | pdf | At journal] | ||
| O'Roak et al. (2012) Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature, to appear [PubMed | pdf | At journal] | ||
| Neale et al. (2012) Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature, to appear [PubMed | pdf | At journal] | ||
| 13 Apr 2012, 3pm, 6201 Microbial Sciences | ||
|
Roberts et al. (2012) The predictive capacity of personal genome sequencing. Science Translational Medicine, Rapid Publication
[PubMed | pdf | At journal] | ||
| 9 Mar 2012, 3pm, 1205A Microbial Sciences | ||
| Main paper: |
Zuk et al. (2012)
The mystery of missing heritability: Genetic interactions create phantom heritability.
Proc Natl Acad Sci USA 109:1193-1198
[PubMed | pdf | At journal] | |
| Related: |
Visscher et al. (2008) Heritability in the genomics era — concepts and misconceptions. Nat Rev Genet 9:255-266 [PubMed | pdf | At journal] | |
| 10 Feb 2012, 3pm, 6201 Microbial Sciences | ||
| Begum et al. (2012) Comprehensive literature review and statistical considerations for GWAS meta-analysis. Nucleic Acids Res, in press [PubMed | pdf | At journal] | ||
| (Note that there's a related seminar the same day: Eleanor Feingold, Friday 10 Feb, noon-1pm, 140 Bardeen) | ||
| 13 Jan 2012, 3pm, 1205A Microbial Sciences | ||
| Main paper: | Worthey et al. (2011) Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med 13:255-262 [PubMed | pdf | At journal] | |
| Related: | Mayer et al. (2011) A timely arrival for genomic medicine. Genet Med 13:195-196 [PubMed | pdf | At journal] | |
| 9 Dec 2011, 3pm, 1205A Microbial Sciences | ||
| Fridley and Biernacka (2011) Gene set analysis of SNP data: benefits, challenges, and future directions. Eur J Hum Genet 19:837-843 [PubMed | pdf | At journal] | ||
| 11 Nov 2011, 3pm, 6201 Microbial Sciences | ||
| Main paper: | Surakka et al. (2011) A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. PLoS Genetics 7:e1002333 [PubMed | pdf | At journal] | |
| Related: | Wang et al. (2011) Statistical interaction in human genetics: how should we model it if we are looking for biological interaction? Nat Rev Genet 12:74 [PubMed | pdf | At journal] | |
| Other related: | Cordell (2009) Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet 10:392-404 [PubMed | pdf | At journal] | |
| VanderWeele (2010) Empirical tests for compositional epistasis. Nat Rev Genet 11:166 [PubMed | pdf | At journal] | ||
| 14 Oct 2011, 3pm, 6201 Microbial Sciences | ||
| Najmabadi et al. (2011) Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature 478:57-63 [PubMed | pdf | At journal] | ||
| 9 Sep 2011, 3pm, 6201 Microbial Sciences | ||
| Kho et al. (2011) Electronic medical records for genetic research:
Results of the eMERGE Consortium. Sci Transl Med 3(79):79re1 [PubMed | pdf | At journal] | ||
| Roque et al. (2011) Using electronic patient records to discover disease
correlations and stratify patient cohorts. PLoS Comp Biol 7(8):e1002141 [PubMed | pdf | At journal] | ||
| 8 Apr 2011, 3pm, 6201 Microbial Sciences | ||
| Editorial: | Shields (2011) Common Disease: Are Causative Alleles Common or Rare? PLoS Biol 9(1): e1001009 [PubMed | pdf | At journal] | |
| Critiques: | Wray et al. (2011) Synthetic Associations Created by Rare Variants Do Not
Explain Most GWAS Results. PLoS Biol 9(1): e1000579 [PubMed | pdf | At journal] | |
| Anderson et al. (2011) Synthetic Associations Are Unlikely to Account
for Many Common Disease Genome-Wide Association Signals. PLoS Biol 9(1): e1000580 [PubMed | pdf | At journal] | ||
| Response: | Goldstein (2011) The Importance of Synthetic Associations Will Only Be Resolved Empirically. PLoS
Biol 9(1): e1001008 [PubMed | pdf | At journal] | |
| Original paper: | Dickson et al. (2010) Rare variants create synthetic genome-wide associations. PLoS Biol 8:e1000294 [PubMed | pdf | At journal] | |
| 11 Mar 2011, 3pm, 6201 Microbial Sciences | ||
| Main paper: | Yang et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42:365-369 [PubMed | pdf | At journal] | |
| Related: | Visscher et al. (2010) A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010). Twin Res Hum Genet 13:517-524 [PubMed | pdf] | |
| Williams and Haines (2011) Correcting away the hidden heritability. Ann Hum Genet, to appear [pdf | At journal] | ||
| 11 Feb 2011, 3pm, 6201 Microbial Sciences | ||
| King, Rathouz, Nicolae (2010) An evolutionary framework for association testing in resequencing studies. PLoS Genetics 6(11):e1001202 [PubMed | pdf | At journal] | ||
| 17 Dec 2010, 3pm, 1205A Microbial Sciences | ||
| de los Campos, Gianola, Allison (2010) Predicting genetic predisposition in humans: The promise of whole-genome markers. Nat Rev Genet 11:880-886 [PubMed | pdf | At journal] | ||
| 19 Nov 2010, 3pm, 6201 Microbial Sciences | ||
| Main paper: | Miyaki et al. (2010) Association of a cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) polymorphism with elevated hemoglobin A1 [PubMed | pdf | At journal] | |
| Commentary: | Franks and Nettleton (2010) Invited commentary: Gene x lifestyle interactions and complex disease traits--inferring cause and effect from observational data, sine qua non. Am J Epidemiol 172:992-997 [PubMed | pdf | At journal] | |
| Response: | Miyaki et al. (2010) Miyaki et al. respond to "Gene x lifestyle interactions". Am J Epidemiol 172:998-999 [PubMed | pdf | At journal] | |
| 22 Oct 2010, 3pm, 6201 Microbial Sciences | ||
| Pelak et al. (2010) The characterization of twenty sequenced human genomes. PLoS Genet 9:e1001111 [PubMed | pdf | At journal] | ||
| 17 Sep 2010, 3pm, 6201 Microbial Sciences | ||
| Zhong et al. (2010) Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet 86:581-591 [PubMed | pdf | Supplement (pdf)] | ||
| 14 May 2010, 3pm, 6201 Microbial Sciences | ||
| Human genome at ten: Life is complicated [pdf | At journal] | ||
| McClellan and King (2010) Genetic heterogeneity in human disease. Cell 141:210-217 [PubMed | pdf | At journal] | ||
| 16 Apr 2010, 3pm, 1420 WARF | ||
| Moore et al. (2010) Bioinformatics challenges for genome-wide association studies. Bioinformatics 26:445-455 [PubMed | pdf | At journal] | ||
| 19 Mar 2010, 3pm, 6201 Microbial Sciences | ||
| Main paper: | Paynter et al. (2010) Association between a literature-based genetic risk score and cardiovascular events in women. JAMA 303:631-637 [PubMed | pdf | At journal] | |
| Related: | Palomaki et al. (2010) Association between 9p21 genomic markers and heart disease. JAMA 303:648--656 [PubMed | pdf | At journal] | |
| Lumley and Rice (2010) Potential for revealing individual-level information in genome-wide association studies. JAMA 303:659-660 [PubMed | pdf | At journal] | ||
| Other related: | Wacholder et al. (2010) Performance of common genetic variants in breast-cancer risk models. N Engl J Med 362:986-993 [PubMed | At journal] | |
| Moonesinghe et al. (2010) Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases. Eur J Hum Genet 18:485-489 [PubMed | At journal] | ||
| 19 Feb 2010, 3pm, 6201 Microbial Sciences | ||
| Main papers: | Amundadottir et al. (2009) Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 41:986-990 [PubMed | pdf | At journal] | |
| Jones et al. (2009) Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 324:217 [PubMed | pdf | At journal] | ||
| Related: | Dickson et al. (2010) Rare variants create synthetic genome-wide associations. PLoS Biol 8:e1000294 [PubMed | pdf | At journal] | |
| 18 Dec 2009, 3pm, 6201 Microbial Sciences | ||
| Fardo et al. (2009) Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium. Eur J Hum Genet 17:1676-1682. [PubMed | pdf] | ||
| 20 Nov 2009, 3pm, 6201 Microbial Sciences | ||
| Plomin et al. (2009) Common disorders are quantitative traits. Nat Rev Genet 10:872-878 [PubMed | pdf] | ||
| 16 Oct 2009, 3pm, 1210 Medical Sciencs Center (MSC) | ||
| Main paper: | Jallow et al. (2009) Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet 41:657-665 [PubMed | pdf] | |
| Related: | Hao et al. (2009) Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies. BMC Genet 10:27 [PubMed | pdf] | |
| Halperin and Stephan (2009) SNP imputation in association studies. Nat Biotechnol 27:349-351 [PubMed | pdf] | ||
| 18 Sep 2009, 3pm, 6201 Microbial Sciences | ||
| Main paper: | Myocardial Infarction Genetics Consortium (2009) Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 41:334-341 [PubMed | pdf] | |
| Related: | Hardy and Singleton (2009) Genomewide association studies and human disease. N Engl J Med 360:1759-1768 [PubMed | pdf] | |
| Web maintainer: Karl Broman | Last modified: Mon Nov 4 14:04:03 2013 |