Interactive graphics for
high-dimensional genetic data

Karl Broman

Biostatistics & Medical Informatics, University of Wisconsin – Madison

http://www.biostat.wisc.edu/~kbroman

Inbred mice

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Human vs mouse

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Intercross

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eQTL project

~500 B6 x BTBR intercross mice, all knocked out for leptin

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Many box plots

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Many box plots

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Many box plots, modernized

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Many box plots, interactive

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Opportunities

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Barriers

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Barriers

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Trade-offs

Easy or flexible?

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D3

http://bl.ocks.org/1136236

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A lot to learn

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Interactive LOD curves

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Interactive eQTL plot

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Summary

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Acknowledgments: Data

Alan Attie
Mark Keller
Biochemistry, UW–Madison
Brian Yandell Statistics and Horticulture, UW–Madison
Christina Kendziorski
Aimee Teo Broman
Biostatistics & Medical Informatics, UW–Madison
Eric Schadt Pacific Biosciences of California
Danielle Greenawalt
Amit Kulkarni
Merck & Co., Inc.

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Acknowledgments: Code

D3 and stack.js by

D3 tutorials by Scott Murray

CoffeeScript by Jeremy Ashkenas

Eloquent JavaScript by Marijn Haverbeke

CoffeeScript book by Trevor Burnham

d3-tip by Justin Palmer

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