GAW 17 course

Analytic Methods in Genetic Epidemiology (Population Health 904 Section 003)
Summer 2010, 6/1/10 – 8/6/10

Mondays, 2:45-4:15, 1220 HSLC

Syllabus (pdf)

Tue 1 June9:00-10:00am1220 HSLC Introduction to course project; form groups
Mon 7 June2:45-4:15pm1220 HSLC Cirulli ET, Goldstein DB (2010) Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet 11:415-425
[PubMed | at journal | pdf]
Mon 14 June2:45-4:15pm1220 HSLC Gorlov et al. (2008) Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet 82:100-112
[PubMed | pdf]
Morris AP, Zeggini E (2010) An evaluation of statistical approaches to rare variant analysis in genetic association studies. Genet Epidemiol 34:188-193
[PubMed | pdf]

Li B, Leal SM (2008) Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet 83:311-321
[PubMed | pdf]
Li et al. (2010) Approaches for evaluating rare polymorphisms in genetic association studies. Hum Hered 69:219-228
[PubMed | pdf]
Mon 21 June2:45-4:15pm1220 HSLC Garrigan D, Hammer MF (2006) Reconstructing human origins in the genomic era. Nat Rev Genet 7:669-80
[PubMed | pdf]
Mon 28 June2:45-4:15pm1220 HSLC Discussion of analysis ideas (5-7 min per group)
Mon 5 July No class
Mon 12 July No class
Mon 19 July No class
Mon 26 July2:45-4:15pm1220 HSLC Relevant paper: Clark AG (2004) The role of haplotypes in candidate gene studies. Genet Epidemiol 27:321-333 [PubMed | pdf]
Mon 2 August2:45-4:15pm1220 HSLC
Mon 9 August2:45-4:15pm1220 HSLC
Mon 16 August2:45-4:15pm1222 HSLC
Mon 23 August2:45-4:15pm1220 HSLC

Links: GAW web site
1000 genomes web site
Email from 16 July regarding GAW 17 data, etc.
README file from data CD
Note regarding data CD
GAW17 wiki discussion forum

Head instructor: Corinne Engelman
Department of Population Health Sciences
1007A WARF
cengleman at wisc dot edu
Co-instructors: Karl Broman
Department of Biostatistics & Medical Informatics
4710 MSC
kbroman at biostat dot wisc dot edu
Bret Payseur
Laboratory of Genetics
2428 Genetic-Biotechnology Center
payseur at wisc dot edu
Kristin Meyers
Department of Population Health Sciences
1007C WARF
kjmeyers2 at wisc dot edu

Web maintainer: Karl Broman Last modified: Mon Aug 16 14:56:29 2010