(3 units) Fourth term, 2000-2001

Tues and Thurs, 8:30-10:00am

W2008 Hygiene

Tuesday, 10:45-11:45am, and Thursday, 3:30-4:30pm, E3612 Hygiene

(or by appointment, or just drop by)

There will be a weekly discussion section for students with a limited background in statistics: Tuesday 3-4pm, W2009 Hygiene

This course will provide an overview of statistical issues in genetics, with an emphasis on human genetics. We will focus on the fundamental problem of gene mapping using linkage and linkage disequilibrium.

Prerequisites: College-level genetics, 140.667 or 340.664; 140.621-622 or similar

Student evaluation will be based on four problem sets.

March | 27 | Overview of statistics in genetics | ||

29 | Models of meiosis: Linkage and interference [refs] | |||

April | 3 | Experimental crosses: Forming linkage maps [refs] | ||

5 | Experimental crosses: Identifying quantitative trait loci [refs] [Problem set 1 (pdf) | solutions] | |||

10 | Human pedigrees: Kinship coefficients and correlation among relatives [refs] | |||

12 | Managing genome scan data [refs] [Problem set 2 (pdf) | solutions] | |||

17 | Linkage analysis in humans: Simple diseases
[refs] Problem set 1 due | |||

19 | Linkage analysis in humans: Model misspecification [refs] | |||

24 | Linkage analysis in humans: Allele-sharing methods
[refs] [Problem set 3 (pdf) | solutions]
Problem set 2 due | |||

26 | Linkage analysis in humans: Quantitative traits in sibships [refs] | |||

May | 1 | Linkage analysis of quantitative traits in large families: Variance components methods [refs] | ||

3 | Linkage analysis of quantitative traits in large
families: MCMC methods
[refs] Problem set 3 due | |||

8 | Linkage disequilibrium: Case-control approaches [refs] | |||

10 | Transmission-disequilibrium test: Dichotomous traits [refs] [Problem set 4 (pdf) | solutions] | |||

15 | Transmission-disequilibrium test: Quantitative traits [refs] | |||

17 | The big picture: Summary and review Problem set 4 due |

- P Sham (1998) Statistics in human genetics. Arnold,
London. (
**strongly**recommended) - J Ott (1999) Analysis of human genetic linkage, 3rd edition. Johns Hopkins University Press, Baltimore.
- K Lange (1997) Mathematical and statistical methods for genetic analysis. Springer-Verlag, New York.
- B S Weir (1996) Genetic data analysis II. Sinauer Associates, Sunderland, MA.

kbroman at jhsph.edu

http://www.biostat.wisc.edu/~kbroman

Last modified: Wed Apr 15 23:02:10 2009