eQTL Mapping via Mixture Over Markers (MOM) Model

Traditional genetic mapping has largely focused on the identification of loci affecting one, or at most a few, complex traits. Microarrays allow for measurement of thousands of gene expression abundances, themselves complex traits, and a number of recent investigations have considered these measurements as phenotypes in mapping studies. These expression quantitative trait loci (eQTL) mapping studies have demonstrated utility for identifying candidate genes, inferring not only correlative but also causal relationships between modulator and modulated genes, identifying regulatory networks, and elucidating subclasses of clinical phenotypes. As a result of these early successes, a number of eQTL mapping efforts are now underway to localize the genetic basis of gene expression. Kendziorski and colleagues (2006) proposed a mixture over markers (MOM) model to facilitate localization of eQTL. The approach calculates transcript specific posterior probabilities that quantify evidence in favor of mapping, while accounting for multiplicities across both markers and transcripts. Details of the approach can be found in Kendziorski et al., 2006.

We are currently updating the MOM code. A new version will be released in August, 2011. If you'd like the original version, please email me directly.

Kendziorski, C., M. Chen, M. Yuan, H. Lan, and A.D. Attie. Statistical Methods for Expression Quantitative Trait Loci (eQTL) Mapping. Biometrics 62: 19-27, 2006 .

**The F2 data set used in the manuscript is available at GEO, accession number GSE3330.

Last Modified August 2010