GOname GO GO.term set.means set.sd n.genes z.score lead.genes GO:0006800 BP oxygen and reactive oxygen species metabolic process 0.0853658536585366 0.271625639078637 41 5.45432550876159 GPX3 EPHX2 FMO2 ALOX12 GO:0008236 MF serine-type peptidase activity 0.0471698113207547 0.208918650740376 159 5.36835725770705 CFD PRSS2 KLK13 PRSS3 DKFZP586H2123 TMPRSS11E PRSS27 DPP4 GO:0006534 BP cysteine metabolic process 0.166666666666667 0.408248290463863 6 4.31153465991471 CBS GO:0006690 BP icosanoid metabolic process 0.097560975609756 0.278825935735943 41 6.3286250196939 CYP2J2 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0006691 BP leukotriene metabolic process 0.136363636363636 0.315542547950509 22 6.66964153139245 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0030574 BP collagen catabolic process 0.1 0.307793505625546 20 4.53924366362541 MMP1 PRSS2 GO:0043616 BP keratinocyte proliferation 0.375 0.478713553878169 4 8.17993843243683 KRT2 EREG GO:0006631 BP fatty acid metabolic process 0.0406976744186047 0.182816116975881 172 4.6315008957829 ACOT2 CYP2J2 ALOX12B EPHX2 RNPEPL1 PLA2G4C ALOX15B ACAA1 ALOX12 GO:0004301 MF epoxide hydrolase activity 0.25 0.5 4 5.38405523326835 EPHX2 GO:0031424 BP keratinization 0.181818181818182 0.394771016975861 22 9.05532214984404 LOR KRT2 IVL LCE3D GO:0009395 BP phospholipid catabolic process 0.115384615384615 0.299572344757639 13 4.27937897314635 PLA2G4F PLA2G4C GO:0008544 BP epidermis development 0.0625 0.238715927658058 120 6.54294124084848 CRABP2 COL17A1 ALOX12B LOR KRT2 IVL LCE3D CST6 GO:0016165 MF lipoxygenase activity 0.285714285714286 0.393397896234722 7 8.17994764579032 ALOX12B ALOX15B ALOX12 GO:0046456 BP icosanoid biosynthetic process 0.103448275862069 0.279646152205514 29 5.67534949438288 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0004179 MF membrane alanyl aminopeptidase activity 0.136363636363636 0.323334895341432 11 4.71452527035636 RNPEPL1 TRHDE GO:0004126 MF cytidine deaminase activity 0.166666666666667 0.408248290463863 6 4.31153465991471 CDA GO:0016116 BP carotenoid metabolic process 0.2 0.447213595499958 5 4.7693489356848 BCDO2 GO:0016108 BP tetraterpenoid metabolic process 0.2 0.447213595499958 5 4.7693489356848 BCDO2 GO:0016290 MF palmitoyl-CoA hydrolase activity 0.2 0.447213595499958 5 4.7693489356848 ACOT2 GO:0004295 MF trypsin activity 0.285714285714286 0.487950036474267 7 8.17994764579032 PRSS2 PRSS3 GO:0004252 MF serine-type endopeptidase activity 0.0520833333333333 0.219015198885048 144 5.76875537715901 CFD PRSS2 KLK13 PRSS3 DKFZP586H2123 TMPRSS11E PRSS27 DPP4 GO:0016284 MF alanine aminopeptidase activity 0.136363636363636 0.323334895341432 11 4.71452527035636 RNPEPL1 TRHDE GO:0018149 BP peptide cross-linking 0.111111111111111 0.323380833381777 18 4.83346282178207 LOR IVL GO:0016801 MF hydrolase activity, acting on ether bonds 0.166666666666667 0.353553390593274 9 5.28102554654419 EPHX2 ALOX12 GO:0016803 MF ether hydrolase activity 0.25 0.418330013267038 6 6.59450653894439 EPHX2 ALOX12 GO:0009898 CC internal side of plasma membrane 0.166666666666667 0.408248290463863 6 4.31153465991471 LOR GO:0016559 BP peroxisome fission 0.25 0.5 4 5.38405523326835 PEX11G GO:0042312 BP regulation of vasodilation 0.166666666666667 0.408248290463863 6 4.31153465991471 EPHX2 GO:0048285 BP organelle fission 0.166666666666667 0.408248290463863 6 4.31153465991471 PEX11G GO:0031638 BP zymogen activation 0.25 0.5 4 5.38405523326835 PRSS3 GO:0016670 MF oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor 0.2 0.273861278752583 5 4.7693489356848 SUOX QSOX1 GO:0048729 BP tissue morphogenesis 0.0740740740740741 0.264350528572715 54 5.332710307539 LOR KRT2 IVL LCE3D GO:0048730 BP epidermis morphogenesis 0.102564102564103 0.307354740604728 39 6.5217588196605 LOR KRT2 IVL LCE3D GO:0005152 MF interleukin-1 receptor antagonist activity 0.166666666666667 0.408248290463863 6 4.31153465991471 IL1F5 GO:0000271 BP polysaccharide biosynthetic process 0.0862068965517241 0.269555371903747 29 4.63617170632251 GYS2 B3GNT8 PPP1R3C GO:0007398 BP ectoderm development 0.0572519083969466 0.229055093927252 131 6.16417478671718 CRABP2 COL17A1 ALOX12B LOR KRT2 IVL LCE3D CST6 GO:0005149 MF interleukin-1 receptor binding 0.153846153846154 0.375533808099405 13 5.83069265558159 IL18 IL1F5 GO:0042104 BP positive regulation of activated T cell proliferation 0.166666666666667 0.408248290463863 6 4.31153465991471 IL18 GO:0019370 BP leukotriene biosynthetic process 0.166666666666667 0.342997170285018 18 7.47060172052023 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0033692 BP cellular polysaccharide biosynthetic process 0.0862068965517241 0.269555371903747 29 4.63617170632251 GYS2 B3GNT8 PPP1R3C GO:0042253 BP granulocyte macrophage colony-stimulating factor biosynthetic process 0.2 0.447213595499958 5 4.7693489356848 IL18 GO:0044421 CC extracellular region part 0.0237467018469657 0.145711751822654 758 4.56120437084613 RPTN FN1 GPX3 APOD SPOCK1 MFAP2 MMP1 COL17A1 PRSS2 IL18 PRSS3 CRISP3 CRISP2 SLURP1 IL1F5 A2ML1 EREG QSOX1 GPC4 CMTM8 SULF2 GO:0004992 MF platelet activating factor receptor activity 0.25 0.5 4 5.38405523326835 PDGFRL GO:0009913 BP epidermal cell differentiation 0.121212121212121 0.331433982639808 33 7.19713847160034 LOR KRT2 IVL LCE3D GO:0044266 BP multicellular organismal macromolecule catabolic process 0.1 0.307793505625546 20 4.53924366362541 MMP1 PRSS2 GO:0044268 BP multicellular organismal protein metabolic process 0.1 0.307793505625546 20 4.53924366362541 MMP1 PRSS2 GO:0044254 BP multicellular organismal protein catabolic process 0.1 0.307793505625546 20 4.53924366362541 MMP1 PRSS2 GO:0044256 BP protein digestion 0.1 0.307793505625546 20 4.53924366362541 MMP1 PRSS2 GO:0044259 BP multicellular organismal macromolecule metabolic process 0.1 0.307793505625546 20 4.53924366362541 MMP1 PRSS2 GO:0044243 BP multicellular organismal catabolic process 0.090909090909091 0.29424494316825 22 4.28396091294086 MMP1 PRSS2 GO:0044236 BP multicellular organismal metabolic process 0.0833333333333333 0.28232985128664 24 4.05941176738344 MMP1 PRSS2 GO:0042573 BP retinoic acid metabolic process 0.25 0.5 4 5.38405523326835 BCDO2 GO:0005576 CC extracellular region 0.0225938967136150 0.143113879437614 1704 6.49861397717538 MMEL1 RPTN FN1 GPX3 APOD SPOCK1 NELL2 MFAP2 ACPP MMP1 COL17A1 PDGFRL CFD PRSS2 CDA KLK13 IL18 SPINK2 PRSS3 CRISP3 ESM1 CRISP2 SOSTDC1 DKFZP586H2123 SLURP1 TMPRSS11E IL1F5 SPINK7 FAM3D RSPO3 PRSS27 SBSN SFTPG A2ML1 EREG QSOX1 STC2 DPP4 GPC4 CST6 GFOD2 CMTM8 EPDR1 SULF2 GO:0005501 MF retinoid binding 0.142857142857143 0.363136519601281 14 5.59100660470554 APOD CRABP2 GO:0005678 CC chromatin assembly complex 0.166666666666667 0.408248290463863 6 4.31153465991471 NAP1L2 GO:0005626 CC insoluble fraction 0.1 0.307793505625546 20 4.53924366362541 LOR GYS2 GO:0010467 BP gene expression 0.00303126994256541 0.0496434878017141 3134 -4.36700444746293 FLJ14959 EREG PIAS3 TFCP2 KHDRBS3 ZSCAN18 MGC21874 CRABP2 NAT14 GLIS2 ZNF607 TCEAL7 LOC134466 GO:0019840 MF isoprenoid binding 0.142857142857143 0.363136519601281 14 5.59100660470554 APOD CRABP2 GO:0055038 CC recycling endosome membrane 0.166666666666667 0.408248290463863 6 4.31153465991471 RAB11FIP5 GO:0010224 BP response to UV-B 0.166666666666667 0.408248290463863 6 4.31153465991471 IVL GO:0001882 MF nucleoside binding 0.2 0.447213595499958 5 4.7693489356848 CDA GO:0015280 MF amiloride-sensitive sodium channel activity 0.1875 0.372011904571422 8 5.63792131927172 SCNN1B SCNN1G GO:0001527 CC microfibril 0.25 0.5 4 5.38405523326835 MFAP2 GO:0001517 MF N-acetylglucosamine 6-O-sulfotransferase activity 0.2 0.447213595499958 5 4.7693489356848 CHST2 GO:0001533 CC cornified envelope 0.15625 0.352077169571293 16 6.57675441952994 LOR IVL CST6 GO:0017171 MF serine hydrolase activity 0.046875 0.208294021448214 160 5.3434730060231 CFD PRSS2 KLK13 PRSS3 DKFZP586H2123 TMPRSS11E PRSS27 DPP4 GO:0045793 BP positive regulation of cell size 0.1875 0.372011904571422 8 5.63792131927172 PRSS2 ALOX12 GO:0017144 BP drug metabolic process 0.166666666666667 0.408248290463863 6 4.31153465991471 EPHX2 GO:0045785 BP positive regulation of cell adhesion 0.107142857142857 0.28946711176092 14 4.09607655394397 PRSS2 ALOX12 GO:0003676 MF nucleic acid binding 0.00330360092500826 0.051311175635777 3027 -4.08798191600173 FLJ14959 PIAS3 TFCP2 KHDRBS3 ZSCAN18 PHC1 MGC21874 DIS3L2 VAT1 ZBED2 NAT14 GLIS2 ZNF607 LOC134466 GO:0008035 MF high-density lipoprotein binding 0.25 0.5 4 5.38405523326835 APOD GO:0043450 BP alkene biosynthetic process 0.166666666666667 0.342997170285018 18 7.47060172052023 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0030353 MF fibroblast growth factor receptor antagonist activity 0.166666666666667 0.408248290463863 6 4.31153465991471 IL1F5 GO:0032604 BP granulocyte macrophage colony-stimulating factor production 0.2 0.447213595499958 5 4.7693489356848 IL18 GO:0043449 BP alkene metabolic process 0.136363636363636 0.315542547950509 22 6.66964153139245 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0030307 BP positive regulation of cell growth 0.214285714285714 0.393397896234722 7 6.06626027722228 PRSS2 ALOX12 GO:0002028 BP regulation of sodium ion transport 0.25 0.5 4 5.38405523326835 SCNN1B GO:0030431 BP sleep 0.2 0.447213595499958 5 4.7693489356848 IL18 GO:0006139 BP nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 0.00310650887573964 0.0507924233944762 3380 -4.52409889107637 FLJ14959 EREG PIAS3 TFCP2 KHDRBS3 ZSCAN18 MGC21874 CRABP2 CDA NAT14 GLIS2 ZNF607 TCEAL7 LOC134466 GO:0045980 BP negative regulation of nucleotide metabolic process 0.2 0.447213595499958 5 4.7693489356848 CDA GO:0045909 BP positive regulation of vasodilation 0.25 0.5 4 5.38405523326835 EPHX2 GO:0051262 BP protein tetramerization 0.111111111111111 0.323380833381777 18 4.83346282178207 GPX3 CDA GO:0032963 BP collagen metabolic process 0.090909090909091 0.29424494316825 22 4.28396091294086 MMP1 PRSS2 GO:0051259 BP protein oligomerization 0.0583333333333333 0.227209801252742 60 4.25625672759887 GPX3 CDA UPK1A AMFR GO:0043205 CC fibril 0.166666666666667 0.408248290463863 6 4.31153465991471 MFAP2 GO:0051289 BP protein homotetramerization 0.222222222222222 0.440958551844098 9 7.14523922236733 GPX3 CDA GO:0006790 BP sulfur metabolic process 0.0506329113924051 0.205609424183839 79 4.11956881725144 CBS GPX3 CHST2 SUOX SULF2 GO:0030280 MF structural constituent of epidermis 0.15 0.337474278855276 10 4.97732929594585 LOR PKP1 GO:0030216 BP keratinocyte differentiation 0.0961538461538462 0.283521807599725 26 4.95702833364436 LOR IVL EREG GO:0008131 MF amine oxidase activity 0.2 0.447213595499958 5 4.7693489356848 AOC3 GO:0008133 MF collagenase activity 0.2 0.447213595499958 5 4.7693489356848 MMP1