GOname	GO	GO.term	set.means	set.sd	n.genes	z.score	lead.genes
GO:0008283	BP	cell proliferation	0.0528120713305898	0.211991911174774	729	5.89608837077224	CDKN3 CSE1L PCNA INSIG1 CDC25B CKS1B BUB1B DLG7 CDC6 CKS2 PIM2 CDC7 TTK CHEK1 LAMP3 BLM GINS1 CDKN2A CENPF MDK CXCR4 TPX2 MKI67 CKLF TIPIN KIF15 HELLS RACGAP1 TCF19 TNFSF13B UHRF1 RECQL4 KLF11 OSMR POLA1 TRAF5 E2F1 TIMELESS CDKN2C BRCA1 HHEX ISG20 PAX6 KIF2C RIPK2 CDCA7
GO:0030705	BP	cytoskeleton-dependent intracellular transport	0.0905172413793103	0.276618855113851	116	5.1997435966754	KIF11 CENPE MPHOSPH1 KIF14 KIFC1 KIF4A KIF20A KIF15 KIF18A KIF22 KIF23 KIF2C
GO:0008278	CC	cohesin complex	0.4	0.547722557505166	5	5.98965301549257	CDCA5 SGOL2
GO:0030894	CC	replisome	0.214285714285714	0.377964473009227	14	5.08989930689492	RPA2 PRIM1 POLA1 RPA3
GO:0043596	CC	nuclear replication fork	0.21875	0.363719214046587	16	5.56851399553546	RPA2 PRIM1 POLA1 MCM7 RPA3
GO:0043566	MF	structure-specific DNA binding	0.0869565217391304	0.263208182888407	92	4.3840307845431	RPA2 RAD51AP1 HLF FEN1 BLM MCM4 PMS2L11 MCM6 RAD51 RPA3
GO:0030554	MF	adenyl nucleotide binding	0.0462154294032023	0.199809304996946	1374	6.45546850469791	RPS6KA5 TK1 TOP2A RUVBL1 SMC4 MCM5 MCM2 STCH ACTL6A LIG1 HLTF CDC2 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L TTK MELK PLK4 CENPE MPHOSPH1 CHEK1 BLM KIF14 POLQ KIFC1 ATP2C1 TPX2 CHEK2 MKI67 MCM4 DNA2 GMPS KIF4A KIF20A ATAD2 DDX60 KIF15 DDX25 HELLS KIF18A CHTF18 SLFN11 MASTL KIAA1804 HSPA6 ACVR1C FIGNL1 RECQL4 SLFN13 FANCM PIF1 PKN3 PMS2L11 RRM1 ARAF MCM6 KIF22 NEK2 KIF23 RAD51 FASTKD2 MCM7 KIF2C AURKB RIPK2 MYO5C MCM8
GO:0043623	BP	cellular protein complex assembly	0.098360655737705	0.286060485025276	61	4.19989605320217	ANLN CSE1L CENPE CENPF MIS12 NUP205 TMEM48
GO:0016363	CC	nuclear matrix	0.108695652173913	0.296517630696742	46	4.14379172050572	RUVBL1 BLM CENPF KIF4A POLA1 GMCL1
GO:0051656	BP	establishment of organelle localization	0.260869565217391	0.448977758544880	23	8.11301804418916	BIRC5 NUSAP1 DLG7 CENPE CENPF CDCA5
GO:0043601	CC	nuclear replisome	0.214285714285714	0.377964473009227	14	5.08989930689492	RPA2 PRIM1 POLA1 RPA3
GO:0004386	MF	helicase activity	0.0928571428571429	0.278651133615421	140	5.914127546076	RUVBL1 HLTF RAD54L BLM POLQ MCM4 DNA2 DDX60 DDX25 HELLS CHTF18 RECQL4 FANCM PIF1 MCM6
GO:0031497	BP	chromatin assembly	0.0897435897435897	0.276146838216693	78	4.21011118852073	MCM2 NEFH CHAF1B HIST1H1C ASF1B HELLS H2AFV CENPA
GO:0051640	BP	organelle localization	0.1875	0.396557769456266	32	6.62271215316399	BIRC5 NUSAP1 DLG7 CENPE CENPF CDCA5
GO:0048015	BP	phosphoinositide-mediated signaling	0.105	0.303972021572693	100	5.85685858534734	PCNA TOP2A SPAG5 BUB1B RFC4 ZWINT AURKA NDC80 CKS2 FEN1 P2RY1
GO:0000082	BP	G1/S transition of mitotic cell cycle	0.176470588235294	0.366852974867781	34	6.36988741086468	CDKN3 DBF4 CDC7 CDKN2A CDCA5 CDKN2C CCNE1
GO:0000085	BP	G2 phase of mitotic cell cycle	0.5	0.5	5	7.57742142227498	BLM CENPF KPNA2
GO:0000086	BP	G2/M transition of mitotic cell cycle	0.235294117647059	0.437237316097603	17	6.22461658257157	BIRC5 CHEK1 CDKN2A CCNB1
GO:0000087	BP	M phase of mitotic cell cycle	0.228365384615385	0.404698517422187	208	21.1903196884832	ANLN BIRC5 MPHOSPH9 NUSAP1 RUVBL1 SMC4 CDC25B CDC20 SPAG5 CDC2 PTTG1 BUB1B DLG7 CDC6 ZWINT AURKA NDC80 SMC2 KIF11 CENPE MPHOSPH1 KNTC1 CENPF KIFC1 SPC25 TPX2 NCAPD3 NCAPH CCNB1 ZWILCH CEP55 NCAPG FBXO5 TIPIN KIF15 DSN1 NCAPG2 HELLS CDCA8 MIS12 NUF2 CDCA5 KIF22 STAG1 TIMELESS CCNA2 NEK2 KIF23 KIAA1009 KIF2C AURKB CDCA3 FAM33A
GO:0000070	BP	mitotic sister chromatid segregation	0.448275862068966	0.506120178878476	29	16.2832202068748	NUSAP1 SMC4 DLG7 ZWINT NDC80 SMC2 CENPE KIFC1 NCAPD3 NCAPH NCAPG NCAPG2 CDCA5
GO:0000075	BP	cell cycle checkpoint	0.318965517241379	0.455938167765286	58	16.0445044960635	BIRC5 FANCG BUB1B CDC6 ZWINT CDC45L RAD1 TTK CHEK1 BLM KNTC1 CDKN2A CENPF CDT1 CHEK2 ZWILCH TIPIN CCNA2 BRCA1 CCNE2
GO:0000076	BP	DNA replication checkpoint	0.666666666666667	0.516397779494322	6	11.1998548304911	CDC6 CDC45L CDT1 TIPIN
GO:0000077	BP	DNA damage checkpoint	0.211538461538462	0.40430377003132	26	6.83943556447481	RAD1 CHEK1 BLM CHEK2 TIPIN CCNA2
GO:0000079	BP	regulation of cyclin-dependent protein kinase activity	0.186274509803922	0.373641329535766	51	8.30351236788713	CDKN3 CKS1B CDC6 CKS2 CHEK1 BLM CDKN2A HERC5 CCNA2 CDKN2C CCNE2
GO:0006996	BP	organelle organization and biogenesis	0.0596669750231267	0.229535521561132	1081	8.92116428127366	ANLN TAF5 RPS6KA5 NUSAP1 TOP2A RUVBL1 SMC4 MCM2 ACTL6A HLTF SPAG5 EZH2 PTTG1 BUB1B DLG7 ZWINT AURKA NDC80 CKS2 SMC2 PIM2 NEFH KIF11 BID CHAF1B TTK CENPE EXOSC9 MPHOSPH1 BLM KIF14 CDKN2A CENPF PTTG3 HIST1H1C KIFC1 ATP2C1 NCAPD3 NCAPH EXOSC8 PRC1 ASF1B KIF4A SUV39H1 NCAPG KIF20A KIF15 NCAPG2 STAG3 HELLS KIF18A MIS12 RACGAP1 NOP5/NOP58 CDCA5 CENPH SASS6 RECQL4 SUV39H2 PIF1 STMN1 KPNA2 KIF22 H2AFV BRCA1 KIF23 CENPA TIMM8A SYCP2 KIF2C TMEM48 BXDC2
GO:0008637	BP	apoptotic mitochondrial changes	0.1875	0.403112887414928	16	4.68061893922213	PIM2 BID CDKN2A
GO:0006950	BP	response to stress	0.0533199195171026	0.213289689641920	994	7.0627756273442	RPS6KA5 PCNA AKR1B1 TOP2A CD14 LIG1 C1QB MDC1 PTTG1 FANCG CD163 RFC4 RAD51AP1 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B CCR1 BARD1 CHEK1 LY75 BLM POLE2 SELE PLA2G7 MICB LY96 POLQ MDK CXCR4 CHEK2 FANCI CCL8 DTL TIPIN DCLRE1B FANCE C1QC UHRF1 GEN1 HSPA6 RECQL4 FANCM POLA1 TOPBP1 PMS2L11 PLSCR1 PLOD2 TIMELESS CCNA2 FANCA BRCA1 RAD51 IL1RAP P2RY1 MCM7 RPA3 RIPK2 CXCL11 MTPN
GO:0006974	BP	response to DNA damage stimulus	0.112956810631229	0.30088463148156	301	11.2155742196962	PCNA TOP2A LIG1 MDC1 PTTG1 FANCG RFC4 RAD51AP1 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B BARD1 CHEK1 BLM POLE2 POLQ CHEK2 FANCI DTL TIPIN DCLRE1B FANCE UHRF1 GEN1 RECQL4 FANCM POLA1 TOPBP1 PMS2L11 TIMELESS CCNA2 FANCA BRCA1 RAD51 MCM7 RPA3
GO:0031224	CC	intrinsic to membrane	0.0130588756086764	0.105975471720561	4518	-5.46706530100404	PIGX ALG10 ACVR1C OSMR KPNA2 TMEM106C LPCAT1 KPNA1 PLSCR1 MMD TMEFF1 NCF4 CELSR3 IL1RAP CD38 SLC25A40 CYP4F3 P2RY1 NUP205 TMEM194 FPRL2 TMEM48 GOLT1B FLRT3 SLAMF8 FA2H NUP62CL AADACL1 TMEM68 TRIM59 HS6ST2 KIAA1524 CLEC2B SLC16A1 TMEM22 CSE1L INSIG1 CD14 TMPO CD163 MRC1 SELL CCR1 CA9 KIAA0133 LAMP3 LY75 SYNGR3 ADAMDEC1 SELE NUP155 GPR19 CXCR4 ATP2C1 TMEM97 NUP210 PAQR4 LPPR4 SLC38A6 FAM69A NUP107 NETO2 CKLF C3orf52 SLC15A3 TMEM180 FICD SLC25A19 TNFSF13B ZIC2 ZDHHC23 C1orf162 ALG10B TMEM71
GO:0016796	MF	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.315789473684211	0.447540386625407	19	9.07353162303705	RAD1 EXO1 FEN1 EXOSC9 EXOSC8 ISG20 XRN2
GO:0016728	MF	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	0.375	0.478713553878169	4	5.00211626211905	RRM2 RRM1
GO:0004748	MF	ribonucleoside-diphosphate reductase activity	0.375	0.478713553878169	4	5.00211626211905	RRM2 RRM1
GO:0016891	MF	endoribonuclease activity, producing 5'-phosphomonoesters	0.173913043478261	0.357029908734864	23	5.15014615196935	RNASEH2A EXO1 FEN1 RPP25 DBR1
GO:0016893	MF	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.142857142857143	0.329341173353118	28	4.51560923437181	RNASEH2A EXO1 FEN1 RPP25 DBR1
GO:0016895	MF	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.4375	0.495515604482557	8	8.33030474025284	RAD1 EXO1 FEN1 ISG20
GO:0016896	MF	exoribonuclease activity, producing 5'-phosphomonoesters	0.25	0.398862017608733	12	5.59071436699254	EXOSC9 EXOSC8 ISG20 XRN2
GO:0033261	BP	regulation of S phase	0.25	0.427425207132555	14	6.03903963640208	CDC7 CDT1 TIPIN TIMELESS
GO:0007093	BP	mitotic cell cycle checkpoint	0.25	0.430516930661509	30	8.84467864746961	BUB1B ZWINT TTK BLM KNTC1 CENPF ZWILCH CCNA2
GO:0007094	BP	mitotic cell cycle spindle assembly checkpoint	0.333333333333333	0.516397779494322	6	5.40196300160203	TTK CENPF
GO:0007096	BP	regulation of exit from mitosis	0.25	0.452267016866645	12	5.59071436699254	ANLN BIRC5 KNTC1
GO:0007098	BP	centrosome cycle	0.192307692307692	0.383973823894152	13	4.34177412787558	KIF11 SASS6 BRCA1
GO:0009719	BP	response to endogenous stimulus	0.0876288659793814	0.269081212857610	388	9.18335554807407	PCNA TOP2A LIG1 MDC1 PTTG1 FANCG RFC4 RAD51AP1 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B BARD1 CHEK1 BLM POLE2 POLQ CHEK2 FANCI DTL TIPIN DCLRE1B FANCE UHRF1 GEN1 RECQL4 FANCM POLA1 TOPBP1 PMS2L11 TIMELESS CCNA2 FANCA BRCA1 RAD51 MCM7 RPA3
GO:0007067	BP	mitosis	0.225728155339806	0.40275660371688	206	20.8163834901619	ANLN BIRC5 NUSAP1 RUVBL1 SMC4 CDC25B CDC20 SPAG5 CDC2 PTTG1 BUB1B DLG7 CDC6 ZWINT AURKA NDC80 SMC2 KIF11 CENPE MPHOSPH1 KNTC1 CENPF KIFC1 SPC25 TPX2 NCAPD3 NCAPH CCNB1 ZWILCH CEP55 NCAPG FBXO5 TIPIN KIF15 DSN1 NCAPG2 HELLS CDCA8 MIS12 NUF2 CDCA5 KIF22 STAG1 TIMELESS CCNA2 NEK2 KIF23 KIAA1009 KIF2C AURKB CDCA3 FAM33A
GO:0007051	BP	spindle organization and biogenesis	0.526315789473684	0.485159888035959	19	15.5924508270800	SPAG5 BUB1B ZWINT AURKA NDC80 CKS2 KIF11 TTK PRC1 STMN1 KIF23
GO:0007052	BP	mitotic spindle organization and biogenesis	0.363636363636364	0.452267016866645	11	8.02921947167474	KIF11 TTK PRC1 STMN1 KIF23
GO:0007059	BP	chromosome segregation	0.375	0.475011150627371	60	19.4071328962727	NUSAP1 TOP2A SMC4 PTTG1 DLG7 ZWINT NDC80 SMC2 CENPE CENPF KIFC1 NCAPD3 NCAPH NCAPG DSN1 NCAPG2 STAG3 MIS12 NUF2 CDCA5 SGOL2 RECQL4 STAG1 BRCA1
GO:0033205	BP	cytokinesis during cell cycle	0.4	0.547722557505166	5	5.98965301549257	NUSAP1 RACGAP1
GO:0007088	BP	regulation of mitosis	0.1625	0.364928865565711	40	6.28232096127722	ANLN BIRC5 NUSAP1 DLG7 MPHOSPH1 KNTC1 NEK2
GO:0007089	BP	traversing start control point of mitotic cell cycle	0.4	0.547722557505166	5	5.98965301549257	CDC2 CDC6
GO:0031570	BP	DNA integrity checkpoint	0.293103448275862	0.453503059119276	29	10.3451965989721	CDC6 CDC45L RAD1 CHEK1 BLM CDT1 CHEK2 TIPIN CCNA2
GO:0031572	BP	G2/M transition DNA damage checkpoint	0.3	0.447213595499958	5	4.40188460871017	BLM CCNA2
GO:0007076	BP	mitotic chromosome condensation	0.5	0.516397779494322	16	13.5595695023554	NUSAP1 SMC4 SMC2 NCAPD3 NCAPH NCAPG NCAPG2 CDCA5
GO:0031576	BP	G2/M transition checkpoint	0.3	0.447213595499958	5	4.40188460871017	BLM CCNA2
GO:0031577	BP	spindle checkpoint	0.428571428571429	0.534522483824849	7	7.6242936629446	BIRC5 TTK CENPF
GO:0007010	BP	cytoskeleton organization and biogenesis	0.0526315789473684	0.216338003855214	475	4.69187450219702	ANLN NUSAP1 SPAG5 BUB1B ZWINT AURKA NDC80 CKS2 KIF11 TTK CENPE MPHOSPH1 KIF14 KIFC1 ATP2C1 PRC1 KIF4A KIF20A KIF15 KIF18A RACGAP1 SASS6 STMN1 KPNA2 KIF22 BRCA1 KIF23 KIF2C
GO:0042393	MF	histone binding	0.214285714285714	0.42581531362632	14	5.08989930689492	DEK CHAF1B ASF1B
GO:0007017	BP	microtubule-based process	0.110552763819095	0.302078984888075	199	8.84758775146	NUSAP1 SPAG5 BUB1B ZWINT AURKA NDC80 CKS2 KIF11 TTK CENPE MPHOSPH1 KIF14 KIFC1 PRC1 KIF4A KIF20A KIF15 KIF18A SASS6 STMN1 KPNA2 KIF22 BRCA1 KIF23 KIF2C
GO:0007018	BP	microtubule-based movement	0.109375	0.300903245509075	96	6.04305376704896	KIF11 CENPE MPHOSPH1 KIF14 KIFC1 KIF4A KIF20A KIF15 KIF18A KIF22 KIF23 KIF2C
GO:0031519	CC	PcG protein complex	0.357142857142857	0.475594865605671	7	6.28230048777512	EZH2 PCGF6 EED
GO:0007049	BP	cell cycle	0.135474860335196	0.325724450339442	716	21.9082825260520	ANLN CDKN3 BIRC5 MPHOSPH9 NUSAP1 RUVBL1 SMC4 CDC25B CKS1B MCM2 LIG1 CDC20 MDC1 SPAG5 CDC2 PTTG1 FANCG BUB1B DLG7 CDC6 ZWINT AURKA CDC45L NDC80 CKS2 SMC2 DBF4 PIM2 KIF11 RAD1 CDC7 RAD54L EXO1 CHAF1B MLF1 TTK CENPE MPHOSPH1 BARD1 CHEK1 BLM KNTC1 CDKN2A CENPF KIFC1 CDT1 SPC25 TPX2 CHEK2 MKI67 NCAPD3 NCAPH FANCI SENP5 CCNB1 PRC1 ZWILCH GMNN CEP55 SUV39H1 NCAPG FBXO5 TIPIN KIF15 DSN1 NCAPG2 STAG3 HERC5 E2F8 HELLS CDCA8 MIS12 RACGAP1 NUF2 MND1 CDCA5 UHRF1 CABLES2 C11orf82 SGOL2 SASS6 RECQL4 CKAP2 SUV39H2 POLA1 CASP8AP2 STMN1 KPNA2 MCM6 KIF22 STAG1 E2F1 TIMELESS CCNA2 CDKN2C BRCA1 NEK2 HHEX KIF23 RAD51 CCNE2 PSMC3IP KIAA1009 SYCP2 MCM7 KIF2C AURKB CCNE1 RBM7 CDCA3 MCM8 FAM33A E2F7
GO:0004523	MF	ribonuclease H activity	0.5	0.547722557505166	6	8.30090891604656	RNASEH2A EXO1 FEN1
GO:0004527	MF	exonuclease activity	0.16	0.34166459266004	50	6.90034993320105	RAD1 EXO1 FEN1 EXOSC9 EXOSC8 ISG20L1 ISG20 LOC81691 XRN2 THEX1
GO:0004529	MF	exodeoxyribonuclease activity	0.4375	0.495515604482557	8	8.33030474025284	RAD1 EXO1 FEN1 ISG20
GO:0004518	MF	nuclease activity	0.0864661654135338	0.257547275709405	133	5.23764453542462	RNASEH2A RAD1 EXO1 FEN1 EXOSC9 EXOSC8 ISG20L1 GEN1 FANCM ISG20 LOC81691 RPP25 DBR1 XRN2 THEX1
GO:0004540	MF	ribonuclease activity	0.132075471698113	0.312418349274999	53	5.65931118193174	RNASEH2A EXO1 FEN1 EXOSC9 EXOSC8 ISG20 RPP25 DBR1 XRN2
GO:0000444	CC	MIS12/MIND type complex	0.5	0.577350269189626	4	6.77723978684211	DSN1 MIS12
GO:0004532	MF	exoribonuclease activity	0.25	0.398862017608733	12	5.59071436699254	EXOSC9 EXOSC8 ISG20 XRN2
GO:0016538	MF	cyclin-dependent protein kinase regulator activity	0.583333333333333	0.491596040125088	6	9.75038187326883	CKS1B CKS2 CABLES2 CCNE2
GO:0000175	MF	3'-5'-exoribonuclease activity	0.277777777777778	0.440958551844098	9	5.43304661794518	EXOSC9 EXOSC8 ISG20
GO:0016605	CC	PML body	0.175	0.335410196624968	20	4.83661788315113	BLM CHEK2 TOPBP1 ISG20 RAD51
GO:0000278	BP	mitotic cell cycle	0.196369636963696	0.379813506871709	303	21.6608949698264	ANLN CDKN3 BIRC5 MPHOSPH9 NUSAP1 RUVBL1 SMC4 CDC25B CDC20 SPAG5 CDC2 PTTG1 BUB1B DLG7 CDC6 ZWINT AURKA NDC80 SMC2 DBF4 KIF11 CDC7 TTK CENPE MPHOSPH1 CHEK1 BLM KNTC1 CDKN2A CENPF KIFC1 CDT1 SPC25 TPX2 NCAPD3 NCAPH CCNB1 PRC1 ZWILCH CEP55 NCAPG FBXO5 TIPIN KIF15 DSN1 NCAPG2 HELLS CDCA8 MIS12 NUF2 CDCA5 POLA1 STMN1 KPNA2 KIF22 STAG1 E2F1 TIMELESS CCNA2 CDKN2C NEK2 KIF23 KIAA1009 KIF2C AURKB CCNE1 CDCA3 FAM33A
GO:0000279	BP	M phase	0.215613382899628	0.393484357404106	269	22.6472382562956	ANLN BIRC5 MPHOSPH9 NUSAP1 RUVBL1 SMC4 CDC25B CDC20 SPAG5 CDC2 PTTG1 BUB1B DLG7 CDC6 ZWINT AURKA NDC80 CKS2 SMC2 PIM2 KIF11 RAD1 RAD54L EXO1 CENPE MPHOSPH1 CHEK1 KNTC1 CENPF KIFC1 SPC25 TPX2 NCAPD3 NCAPH CCNB1 ZWILCH CEP55 NCAPG FBXO5 TIPIN KIF15 DSN1 NCAPG2 STAG3 HELLS CDCA8 MIS12 NUF2 MND1 CDCA5 KPNA2 KIF22 STAG1 TIMELESS CCNA2 NEK2 KIF23 RAD51 PSMC3IP KIAA1009 SYCP2 KIF2C AURKB RBM7 CDCA3 FAM33A
GO:0000226	BP	microtubule cytoskeleton organization and biogenesis	0.146067415730337	0.338800081764265	89	8.28171930618045	NUSAP1 SPAG5 BUB1B ZWINT AURKA NDC80 CKS2 KIF11 TTK PRC1 SASS6 STMN1 BRCA1 KIF23 KIF2C
GO:0000228	CC	nuclear chromosome	0.161290322580645	0.339126838546761	93	9.5121423489748	RPA2 MCM2 SMC2 PRIM1 CHEK1 BLM NCAPD3 SUV39H1 ORC6L TIPIN STAG3 PIF1 POLA1 TOPBP1 TIMELESS RAD51 SYCP2 MCM7 RPA3
GO:0000793	CC	condensed chromosome	0.254716981132075	0.423159379746726	53	12.0086802058052	SMC4 BUB1B SMC2 CENPE CHEK1 BLM CENPF NCAPD3 SUV39H1 DSN1 STAG3 MIS12 TOPBP1 RAD51 SYCP2
GO:0000794	CC	condensed nuclear chromosome	0.209677419354839	0.382408889985294	31	7.39570743867325	CHEK1 BLM NCAPD3 SUV39H1 STAG3 TOPBP1 RAD51 SYCP2
GO:0000795	CC	synaptonemal complex	0.192307692307692	0.383973823894152	13	4.34177412787558	BLM STAG3 SYCP2
GO:0000796	CC	condensin complex	0.75	0.5	4	10.3274868362882	SMC4 SMC2 NCAPD3
GO:0007346	BP	regulation of mitotic cell cycle	0.225	0.416044733579195	60	11.1426169163087	BIRC5 CDC2 BUB1B CDC6 ZWINT TTK BLM KNTC1 CDKN2A CENPF CDT1 ZWILCH FBXO5 CCNA2
GO:0000785	CC	chromatin	0.0980392156862745	0.281319865763271	153	6.64242275524085	DNMT1 MYBL2 MCM2 TMPO NEFH CENPF HIST1H1C HMG4L ASF1B SUV39H1 TIPIN HELLS SUV39H2 POLA1 H2AFV TIMELESS CENPA MCM7
GO:0000775	CC	chromosome, pericentric region	0.337837837837838	0.446509354303124	74	19.2872940413001	BIRC5 BUB1B ZWINT NDC80 CENPE ITGB3BP CENPF SPC25 APITD1 ZWILCH SUV39H1 CENPM DSN1 CENPN HELLS CDCA8 MIS12 CENPK NUF2 SGOL2 CENPH SUV39H2 KIF22 CENPA KIF2C AURKB MLF1IP CENPQ CENPO
GO:0000776	CC	kinetochore	0.274193548387097	0.444197960325111	31	9.94843674071192	BUB1B ZWINT CENPE CENPF ZWILCH DSN1 MIS12 CENPH KIF22
GO:0000777	CC	condensed chromosome kinetochore	0.625	0.517549169506766	8	12.0963815574585	BUB1B CENPE CENPF DSN1 MIS12
GO:0000779	CC	condensed chromosome, pericentric region	0.555555555555556	0.52704627669473	9	11.3510505460926	BUB1B CENPE CENPF DSN1 MIS12
GO:0000724	BP	double-strand break repair via homologous recombination	0.307692307692308	0.434859246311452	13	7.2965900651807	RAD51AP1 RAD54L BLM BRCA1 RAD51
GO:0000725	BP	recombinational repair	0.307692307692308	0.434859246311452	13	7.2965900651807	RAD51AP1 RAD54L BLM BRCA1 RAD51
GO:0044454	CC	nuclear chromosome part	0.171875	0.3475395375475	64	8.4861014859688	RPA2 MCM2 PRIM1 BLM NCAPD3 ORC6L TIPIN STAG3 PIF1 POLA1 TIMELESS SYCP2 MCM7 RPA3
GO:0044459	CC	plasma membrane part	0.00959860383944154	0.0921595235782788	1719	-4.10168266980298	ACVR1C OSMR MMD NCF4 IL1RAP P2RY1 FLRT3 CLEC2B MDC1 CD163 MRC1 SELL CCR1 LY75 SYNGR3 MICB GPR19 CXCR4 TNFSF13B ZIC2
GO:0044422	CC	organelle part	0.0406365883807169	0.186405259449730	3236	8.08262809225835	ANLN TAF5 FILIP1L BIRC5 CEP78 MPHOSPH9 NUSAP1 CSE1L PCNA TOP2A RUVBL1 INSIG1 SMC4 DNMT1 MYBL2 RPA2 CDC25B MCM2 ACTL6A CDC20 SPAG5 CDC2 EZH2 TMPO BUB1B DLG7 CDC6 RFC4 ZWINT TOE1 AURKA NDC80 SMC2 NEFH KIF11 BID WDHD1 CHAF1B TTK CENPE PRIM1 EXOSC9 ITGB3BP MPHOSPH1 BARD1 CHEK1 LAMP3 BLM KNTC1 KIF14 ABAT NUP155 TAF1A KRT31 CDKN2A CENPF POLQ HIST1H1C KIFC1 CDT1 SPC25 ATP2C1 TPX2 RPL39L CHEK2 MKI67 NUP210 NCAPD3 APITD1 CCNB1 HMG4L PRC1 ASF1B ZWILCH KIF4A SUV39H1 CENPM KIF20A NUP107 FBXO5 ORC6L TIPIN KIF15 C3orf52 DSN1 CENPN SLC15A3 STAG3 E2F8 HELLS KIF18A CDCA8 MIS12 RACGAP1 CENPK NOP5/NOP58 SLC25A19 NUF2 PCGF6 CDCA5 SGOL2 CENPH KRT80 SASS6 PIGX ALG10 CKAP2 SUV39H2 CYP4B1 PIF1 POLA1 CEP72 TOPBP1 RPL30 STMN1 KPNA2 TMEM106C LPCAT1 KPNA1 KIF22 H2AFV PLOD2 E2F1 TIMELESS MMD BRCA1 NEK2 ISG20 KIF23 CENPA RAD51 TIMM8A SLC25A40 KIAA1009 CYP4F3 SYCP2 CYP7B1 LOC81691 MCM7 KIF2C AURKB RPA3 EED NUP205 DMN TMEM48 GOLT1B GMCL1 KTELC1 MLF1IP MYO5C CENPQ FA2H CENPO NUP62CL XRN2 FAM33A NOM1 E2F7
GO:0044424	CC	intracellular part	0.0285935085007728	0.157298000841075	9058	5.98340834241653	ANLN TAF5 KIAA1524 RPS6KA5 TK1 FILIP1L BIRC5 CEP78 MPHOSPH9 TMEM22 IFI44 NUSAP1 STAT1 DEK CSE1L PCNA AKR1B1 TOP2A ENO2 IFI30 RUVBL1 INSIG1 SMC4 DNMT1 MYBL2 MCM5 RPA2 MTHFD2 CDC25B RRM2 MCM2 STCH FOXM1 ACTL6A LIG1 CDC20 C1QB HLTF RNASEH2A MDC1 SPAG5 CDC2 MTF2 EZH2 TMPO LSP1 PTTG1 FANCG BUB1B DLG7 VRK1 CDC6 RFC4 ZWINT TRIP13 TOE1 AURKA CDC45L RAD51AP1 NDC80 GCH1 SMC2 DBF4 S100P NEFH APOC1 KIF11 RAD1 BID CDC7 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 CHAF1B MLF1 TTK MELK CENPE PRIM1 EXOSC9 ITGB3BP CA9 MPHOSPH1 BARD1 CHEK1 ISG15 LAMP3 RASGRP1 CYP27B1 BLM POLE2 GINS1 ISL1 NTS KNTC1 KIF14 ABAT NUP155 TAF1A KRT31 ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ ANP32E PRSS16 PTTG3 CXCR4 HIST1H1C IFI35 KIFC1 CDT1 SPC25 ATP2C1 NCF2 TPX2 RPL39L IRX5 CHEK2 MKI67 MCM4 ASXL1 NUP210 NCAPD3 NCAPH FANCI SENP5 APITD1 TWIST1 GMPS HOXD11 CCNB1 EXOSC8 HMG4L PRC1 ASF1B ZWILCH KIF4A DTL SUV39H1 NCAPG HJURP CENPM KIF20A NUP107 FBXO5 RMI1 ORC6L USP18 TIPIN KIF15 C3orf52 DCLRE1B DSN1 CENPN NCAPG2 SLC15A3 STAG3 HERC5 DDX25 GIPC2 E2F8 HELLS FANCE MCM10 MXD3 KIF18A PUS3 CDCA8 MIS12 DONSON RACGAP1 PRTFDC1 CENPK NOP5/NOP58 SLC25A19 TCF19 NUF2 ZIC2 MND1 PCGF6 BEX2 CDCA5 C15orf23 C1QC PHF19 UHRF1 SLFN11 C6orf173 HYLS1 C11orf82 GEN1 SGOL2 EID3 CENPH KRT80 SASS6 ZNF541 ZNF280C PIGX ALG10 RECQL4 KLF11 CKAP2 FANCM SUV39H2 AGBL3 PSIP1 ZNF26 CYP4B1 PIF1 HMMR GINS2 POLA1 CEP72 PKN3 TOPBP1 NEDD4 TACC3 TRAF5 CASP8AP2 RPL30 STMN1 KPNA2 RRM1 TMEM106C LPCAT1 MCM6 KPNA1 KIF22 CSTF1 STAG1 H2AFV KIAA0101 PLOD2 E2F1 TIMELESS MMD CCNA2 FANCA CDKN2C TEAD4 BRCA1 NEK2 HHEX ISG20 KIF23 CENPA RAD51 CCNE2 NCF4 TIMM8A PAX6 SLC25A40 PSMC3IP KIAA1009 LHX2 FOXD1 CYP4F3 SYCP2 PTP4A3 SP4 POU2F3 ZNF200 CYP7B1 LOC81691 MCM7 KIF2C AURKB RPA3 RIPK2 EED ANXA9 NUP205 SULF1 DMN ZNF473 CCNE1 TMEM48 GOLT1B COQ4 S100PBP GMCL1 KTELC1 ABHD10 MLF1IP MYO5C RPP25 DBR1 BXDC2 HSPBAP1 CENPQ FA2H CENPO ATG3 DOK3 NUP62CL CDCA3 COL8A2 XRN2 PARP9 MCM8 CDCA7 MTPN FAM33A NOM1 E2F7 IRX2 ZNF367
GO:0044425	CC	membrane part	0.0123854105714843	0.103077429075642	5127	-6.40025273466258	PIGX ALG10 ACVR1C OSMR CYP4B1 KPNA2 TMEM106C LPCAT1 KPNA1 PLSCR1 PLOD2 MMD TMEFF1 NCF4 CELSR3 IL1RAP CD38 SLC25A40 CYP4F3 CYP7B1 P2RY1 NUP205 TMEM194 FPRL2 TMEM48 GOLT1B FLRT3 SLAMF8 FA2H NUP62CL AADACL1 TMEM68 TRIM59 HS6ST2 KIAA1524 CLEC2B SLC16A1 MPHOSPH9 TMEM22 CSE1L INSIG1 CD14 MDC1 TMPO CD163 MRC1 SELL CCR1 CA9 KIAA0133 LAMP3 LY75 SYNGR3 ADAMDEC1 SELE MICB NUP155 GPR19 CXCR4 ATP2C1 TMEM97 NUP210 PAQR4 LPPR4 SLC38A6 FAM69A NUP107 NETO2 CKLF C3orf52 SLC15A3 TMEM180 FICD SLC25A19 TNFSF13B ZIC2 ZDHHC23 C1orf162 ALG10B TMEM71
GO:0044427	CC	chromosomal part	0.179078014184397	0.366315502364984	282	18.8028456637881	BIRC5 PCNA SMC4 DNMT1 MYBL2 RPA2 MCM2 TMPO BUB1B RFC4 ZWINT NDC80 SMC2 NEFH CENPE PRIM1 ITGB3BP CHEK1 BLM CENPF HIST1H1C CDT1 SPC25 NCAPD3 APITD1 HMG4L ASF1B ZWILCH SUV39H1 CENPM ORC6L TIPIN DSN1 CENPN STAG3 HELLS CDCA8 MIS12 CENPK NUF2 CDCA5 SGOL2 CENPH SUV39H2 PIF1 POLA1 KIF22 H2AFV TIMELESS CENPA SYCP2 MCM7 KIF2C AURKB RPA3 MLF1IP CENPQ CENPO
GO:0044428	CC	nuclear part	0.050251256281407	0.205525868154874	995	6.35691156106292	TAF5 CSE1L PCNA TOP2A RUVBL1 RPA2 MCM2 ACTL6A EZH2 TMPO BUB1B TOE1 SMC2 WDHD1 CHAF1B PRIM1 EXOSC9 MPHOSPH1 BARD1 CHEK1 BLM NUP155 TAF1A CDKN2A CENPF POLQ CHEK2 MKI67 NUP210 NCAPD3 KIF4A SUV39H1 NUP107 ORC6L TIPIN STAG3 E2F8 NOP5/NOP58 PCGF6 PIF1 POLA1 TOPBP1 KPNA2 KPNA1 E2F1 TIMELESS BRCA1 ISG20 RAD51 SYCP2 LOC81691 MCM7 RPA3 EED NUP205 TMEM48 GMCL1 NUP62CL XRN2 NOM1 E2F7
GO:0044446	CC	intracellular organelle part	0.0407625542467452	0.186680279777608	3226	8.12382028798654	ANLN TAF5 FILIP1L BIRC5 CEP78 MPHOSPH9 NUSAP1 CSE1L PCNA TOP2A RUVBL1 INSIG1 SMC4 DNMT1 MYBL2 RPA2 CDC25B MCM2 ACTL6A CDC20 SPAG5 CDC2 EZH2 TMPO BUB1B DLG7 CDC6 RFC4 ZWINT TOE1 AURKA NDC80 SMC2 NEFH KIF11 BID WDHD1 CHAF1B TTK CENPE PRIM1 EXOSC9 ITGB3BP MPHOSPH1 BARD1 CHEK1 LAMP3 BLM KNTC1 KIF14 ABAT NUP155 TAF1A KRT31 CDKN2A CENPF POLQ HIST1H1C KIFC1 CDT1 SPC25 ATP2C1 TPX2 RPL39L CHEK2 MKI67 NUP210 NCAPD3 APITD1 CCNB1 HMG4L PRC1 ASF1B ZWILCH KIF4A SUV39H1 CENPM KIF20A NUP107 FBXO5 ORC6L TIPIN KIF15 C3orf52 DSN1 CENPN SLC15A3 STAG3 E2F8 HELLS KIF18A CDCA8 MIS12 RACGAP1 CENPK NOP5/NOP58 SLC25A19 NUF2 PCGF6 CDCA5 SGOL2 CENPH KRT80 SASS6 PIGX ALG10 CKAP2 SUV39H2 CYP4B1 PIF1 POLA1 CEP72 TOPBP1 RPL30 STMN1 KPNA2 TMEM106C LPCAT1 KPNA1 KIF22 H2AFV PLOD2 E2F1 TIMELESS MMD BRCA1 NEK2 ISG20 KIF23 CENPA RAD51 TIMM8A SLC25A40 KIAA1009 CYP4F3 SYCP2 CYP7B1 LOC81691 MCM7 KIF2C AURKB RPA3 EED NUP205 DMN TMEM48 GOLT1B GMCL1 KTELC1 MLF1IP MYO5C CENPQ FA2H CENPO NUP62CL XRN2 FAM33A NOM1 E2F7
GO:0044430	CC	cytoskeletal part	0.067699836867863	0.240643394025701	613	8.0548370620303	ANLN FILIP1L BIRC5 CEP78 NUSAP1 TOP2A CDC25B CDC20 SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA NEFH KIF11 TTK CENPE MPHOSPH1 KNTC1 KIF14 KRT31 CENPF KIFC1 TPX2 CCNB1 PRC1 KIF4A KIF20A FBXO5 KIF15 KIF18A RACGAP1 KRT80 SASS6 CKAP2 CEP72 STMN1 KIF22 BRCA1 NEK2 KIF23 KIAA1009 KIF2C AURKB DMN MYO5C FAM33A
GO:0042770	BP	DNA damage response, signal transduction	0.133333333333333	0.326830509313592	45	5.27341346414082	RAD1 CHEK1 BLM CHEK2 TIPIN CCNA2 BRCA1
GO:0000819	BP	sister chromatid segregation	0.433333333333333	0.504006932993731	30	15.9805016896370	NUSAP1 SMC4 DLG7 ZWINT NDC80 SMC2 CENPE KIFC1 NCAPD3 NCAPH NCAPG NCAPG2 CDCA5
GO:0005730	CC	nucleolus	0.0674846625766871	0.239052511299030	163	4.07448462061927	TAF5 TOP2A EXOSC9 MPHOSPH1 BLM TAF1A CDKN2A MKI67 NOP5/NOP58 POLA1 LOC81691 XRN2 NOM1
GO:0000808	CC	origin recognition complex	0.333333333333333	0.516397779494322	6	5.40196300160203	MCM2 ORC6L
GO:0007126	BP	meiosis	0.152173913043478	0.335457850272524	69	7.64837816044606	CKS2 PIM2 RAD1 RAD54L EXO1 CHEK1 STAG3 MND1 NEK2 RAD51 PSMC3IP SYCP2 RBM7
GO:0007127	BP	meiosis I	0.172413793103448	0.360452643733382	29	5.72673379282562	CKS2 RAD1 CHEK1 STAG3 RAD51 SYCP2
GO:0007130	BP	synaptonemal complex assembly	0.3	0.447213595499958	5	4.40188460871017	STAG3 SYCP2
GO:0005856	CC	cytoskeleton	0.0425851703406814	0.19378541902424	998	4.59143620977099	ANLN FILIP1L BIRC5 CEP78 NUSAP1 TOP2A CDC25B CDC20 SPAG5 CDC2 LSP1 BUB1B DLG7 CDC6 AURKA NEFH KIF11 TTK CENPE MPHOSPH1 KNTC1 KIF14 KRT31 CENPF KIFC1 TPX2 CCNB1 PRC1 KIF4A KIF20A FBXO5 KIF15 KIF18A RACGAP1 KRT80 SASS6 CKAP2 CEP72 STMN1 KIF22 BRCA1 NEK2 KIF23 KIAA1009 KIF2C AURKB DMN MYO5C FAM33A
GO:0005886	CC	plasma membrane	0.0116926503340757	0.101751613419387	2694	-4.47350237306307	ACVR1C OSMR PLSCR1 MMD TMEFF1 NCF4 CELSR3 IL1RAP CD38 PTP4A3 P2RY1 FPRL2 FLRT3 CLEC2B SLC16A1 ENO2 CD14 ACTL6A RGS1 MDC1 LSP1 CD163 MRC1 SELL CCR1 CA9 RASGRP1 LY75 SYNGR3 SELE MICB LY96 GPR19 CXCR4 TNFSF13B ZIC2 ALG10B GBP5
GO:0003008	BP	system process	0.00384985563041386	0.0579399112152942	1039	-4.47599328847079	TIMM8A PAX6 GCH1 NTS ABAT
GO:0005871	CC	kinesin complex	0.176470588235294	0.350944104817110	17	4.5017931996461	KIF11 KIF15 KIF23 KIF2C
GO:0005874	CC	microtubule	0.084862385321101	0.268808995209991	218	6.55438314528769	BIRC5 NUSAP1 SPAG5 CDC2 KIF11 CENPE MPHOSPH1 KNTC1 KIF14 KIFC1 PRC1 KIF4A KIF20A KIF15 KIF18A RACGAP1 CKAP2 STMN1 KIF22 KIF23 KIF2C
GO:0005875	CC	microtubule associated complex	0.0897435897435897	0.275551051463907	117	5.16264233708007	KIF11 CENPE MPHOSPH1 KIF14 KIFC1 KIF4A KIF20A KIF15 KIF18A KIF22 KIF23 KIF2C
GO:0005876	CC	spindle microtubule	0.388888888888889	0.50163132570455	18	11.0343241154904	BIRC5 SPAG5 CDC2 KIF11 KNTC1 PRC1 KIF4A
GO:0005813	CC	centrosome	0.0954198473282443	0.284973033925303	131	5.9283499908945	BIRC5 CEP78 TOP2A CDC25B DLG7 AURKA MPHOSPH1 KIFC1 CCNB1 KIF15 SASS6 CEP72 NEK2 KIAA1009
GO:0005814	CC	centriole	0.285714285714286	0.487950036474267	7	4.94030731260564	BIRC5 TOP2A
GO:0005815	CC	microtubule organizing center	0.0928571428571429	0.278651133615421	140	5.914127546076	BIRC5 CEP78 TOP2A CDC25B DLG7 AURKA MPHOSPH1 KIFC1 CCNB1 KIF15 SASS6 CEP72 BRCA1 NEK2 KIAA1009
GO:0005819	CC	spindle	0.301369863013699	0.446745375740829	73	16.938749829829	BIRC5 CDC20 SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA KIF11 TTK CENPE KNTC1 KIF14 CENPF KIFC1 TPX2 PRC1 KIF4A FBXO5 RACGAP1 KIF23 KIAA1009 AURKB FAM33A
GO:0019238	MF	cyclohydrolase activity	0.4	0.547722557505166	5	5.98965301549257	MTHFD2 GCH1
GO:0005524	MF	ATP binding	0.0495319812792512	0.206462187355896	1282	7.09511631441636	RPS6KA5 TK1 TOP2A RUVBL1 SMC4 MCM5 MCM2 STCH ACTL6A LIG1 HLTF CDC2 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L TTK MELK PLK4 CENPE MPHOSPH1 CHEK1 BLM KIF14 POLQ KIFC1 ATP2C1 TPX2 CHEK2 MKI67 MCM4 DNA2 GMPS KIF4A KIF20A ATAD2 DDX60 KIF15 DDX25 HELLS KIF18A CHTF18 SLFN11 MASTL KIAA1804 HSPA6 ACVR1C FIGNL1 RECQL4 SLFN13 FANCM PIF1 PKN3 PMS2L11 RRM1 ARAF MCM6 KIF22 NEK2 KIF23 RAD51 FASTKD2 MCM7 KIF2C AURKB RIPK2 MYO5C MCM8
GO:0005515	MF	protein binding	0.0282185628742515	0.157381059402623	6680	4.14875021400808	ANLN TAF5 RPS6KA5 CDKN3 BIRC5 SLC16A1 STAT1 DEK CSE1L PCNA AKR1B1 TOP2A RUVBL1 INSIG1 SMC4 DNMT1 CD14 MCM5 RPA2 CDC25B RRM2 CKS1B MCM2 FOXM1 ACTL6A CDC20 HLTF RGS1 MDC1 CDC2 MTF2 EZH2 TMPO LSP1 PTTG1 FANCG CD163 BUB1B DLG7 MMP9 CDC6 RFC4 ZWINT TRIP13 AURKA CDC45L RAD51AP1 NDC80 GCH1 SMC2 DBF4 PIM2 S100P RAD1 BID CDC7 SELL EXO1 PARP2 HLF NUDT1 FEN1 CHAF1B MLF1 MELK PLK4 FST CENPE PRIM1 EXOSC9 CCR1 ITGB3BP NMB MPHOSPH1 BARD1 CHEK1 ISG15 RASGRP1 BLM GINS1 ISL1 ADAMDEC1 SELE MICB NTS KNTC1 AIM2 ABAT TAF1A KRT31 ZNF165 HOXC6 CDKN2A CENPF HOXD10 ANP32E MDK CXCR4 HIST1H1C IFI35 CDT1 SPC25 NCF2 TPX2 CHEK2 MKI67 MCM4 NUP210 FANCI TWIST1 CCL8 CCNB1 EXOSC8 PRC1 ASF1B ZWILCH GMNN KIF4A SNX10 GREM1 RFWD3 DTL SUV39H1 NCAPG NUP107 FBXO5 ORC6L PELI2 CKLF TIPIN BOLA1 SHCBP1 DSN1 FICD GIPC2 FANCE MCM10 MXD3 CDCA8 MIS12 RACGAP1 TCF19 NUF2 TNFSF13B PCGF6 CDCA5 C15orf23 PHF19 UHRF1 OVOS2 KIAA1804 SGOL2 CENPH TRIM74 FANCM FCHSD2 GINS2 POLA1 CEP72 PKN3 TOPBP1 SPP1 TRIM52 NEDD4 TRAF5 CASP8AP2 STMN1 KPNA2 RRM1 ARAF MCM6 KPNA1 CSTF1 STAG1 PLSCR1 PLOD2 E2F1 TIMELESS CCNA2 FANCA LCMT2 CDKN2C BRCA1 NEK2 HHEX KIF23 RAD51 CCNE2 NCF4 TIMM8A IL1RAP PAX6 PSMC3IP IL24 PTP4A3 SP4 POU2F3 MCM7 KIF2C AURKB RIPK2 EED ANXA9 CXCL11 NUP205 DMN CCNE1 S100PBP GMCL1 MSL2L1 MYO5C RPP25 BXDC2 FLRT3 ATG3 DOK3 COL8A2 XRN2 MTPN DOCK11 NOM1 TRIM59 E2F7 PPIL5
GO:0005694	CC	chromosome	0.158284023668639	0.347871035543507	338	17.8788226815391	BIRC5 PCNA TOP2A SMC4 DNMT1 MYBL2 RPA2 MCM2 TMPO BUB1B RFC4 ZWINT NDC80 SMC2 NEFH CENPE PRIM1 ITGB3BP CHEK1 BLM CENPF HIST1H1C CDT1 SPC25 NCAPD3 FANCI APITD1 HMG4L ASF1B ZWILCH SUV39H1 CENPM ORC6L TIPIN DSN1 CENPN STAG3 HELLS CDCA8 MIS12 CENPK NUF2 CDCA5 SGOL2 CENPH SUV39H2 PIF1 POLA1 TOPBP1 KIF22 H2AFV TIMELESS CENPA RAD51 SYCP2 MCM7 KIF2C AURKB RPA3 MLF1IP CENPQ CENPO
GO:0005663	CC	DNA replication factor C complex	0.333333333333333	0.516397779494322	6	5.40196300160203	PCNA RFC4
GO:0005664	CC	nuclear origin of replication recognition complex	0.333333333333333	0.516397779494322	6	5.40196300160203	MCM2 ORC6L
GO:0017056	MF	structural constituent of nuclear pore	0.4	0.418330013267038	5	5.98965301549257	NUP155 TMEM48 NUP62CL
GO:0005657	CC	replication fork	0.316666666666667	0.444958993332112	30	11.4395233900759	PCNA DNMT1 RPA2 RFC4 PRIM1 CHEK1 BLM CDT1 POLA1 MCM7 RPA3
GO:0017076	MF	purine nucleotide binding	0.0383933845245127	0.182743134467428	1693	4.82878642294667	RPS6KA5 TK1 TOP2A RUVBL1 SMC4 MCM5 MCM2 STCH ACTL6A LIG1 HLTF CDC2 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L TTK MELK PLK4 CENPE MPHOSPH1 CHEK1 BLM KIF14 POLQ KIFC1 ATP2C1 TPX2 CHEK2 MKI67 MCM4 DNA2 GMPS KIF4A KIF20A ATAD2 DDX60 KIF15 DDX25 HELLS KIF18A CHTF18 SLFN11 MASTL KIAA1804 GBP5 HSPA6 ACVR1C FIGNL1 RECQL4 SLFN13 FANCM PIF1 PKN3 PMS2L11 RRM1 ARAF MCM6 KIF22 NEK2 KIF23 RAD51 FASTKD2 MCM7 KIF2C AURKB RIPK2 MYO5C MCM8 DOCK11
GO:0005622	CC	intracellular	0.0282551396942541	0.156042237683128	9485	5.95375232342813	ANLN TAF5 KIAA1524 RPS6KA5 TK1 FILIP1L BIRC5 CEP78 MPHOSPH9 ARHGAP11B TMEM22 IFI44 NUSAP1 STAT1 DEK CSE1L PCNA AKR1B1 TOP2A ENO2 IFI30 RUVBL1 INSIG1 SMC4 DNMT1 MYBL2 MCM5 RPA2 MTHFD2 CDC25B RRM2 MCM2 STCH FOXM1 ACTL6A LIG1 CDC20 C1QB HLTF RNASEH2A MDC1 SPAG5 CDC2 MTF2 EZH2 TMPO LSP1 PTTG1 FANCG BUB1B DLG7 VRK1 CDC6 RFC4 ZWINT TRIP13 TOE1 AURKA CDC45L RAD51AP1 NDC80 GCH1 SMC2 DBF4 S100P NEFH APOC1 KIF11 RAD1 BID CDC7 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 CHAF1B MLF1 TTK MELK CENPE PRIM1 EXOSC9 ITGB3BP CA9 MPHOSPH1 BARD1 CHEK1 ISG15 LAMP3 RASGRP1 CYP27B1 BLM POLE2 GINS1 ISL1 NTS KNTC1 KIF14 ABAT NUP155 TAF1A KRT31 ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ ANP32E PRSS16 PTTG3 CXCR4 HIST1H1C IFI35 KIFC1 CDT1 SPC25 ATP2C1 NCF2 TPX2 RPL39L IRX5 CHEK2 MKI67 MCM4 ASXL1 NUP210 NCAPD3 NCAPH FANCI SENP5 APITD1 TWIST1 GMPS HOXD11 CCNB1 EXOSC8 HMG4L PRC1 ASF1B TBC1D15 ZWILCH KIF4A DTL SUV39H1 NCAPG HJURP CENPM KIF20A NUP107 FBXO5 RMI1 ORC6L USP18 TIPIN KIF15 ISG20L1 C3orf52 DCLRE1B DSN1 CENPN NCAPG2 SLC15A3 STAG3 HERC5 DDX25 GIPC2 E2F8 HELLS FANCE DEPDC1 MCM10 MXD3 KIF18A PUS3 CDCA8 MIS12 DONSON RACGAP1 PRTFDC1 CENPK NOP5/NOP58 SLC25A19 TCF19 NUF2 ZIC2 MND1 PCGF6 BEX2 CDCA5 C15orf23 C1QC PHF19 UHRF1 SLFN11 C6orf173 HYLS1 PLEKHG4 C11orf82 GEN1 SGOL2 EID3 CENPH KRT80 SASS6 ZNF541 ZNF280C PIGX ALG10 RECQL4 KLF11 SLFN13 TRIM74 CKAP2 FANCM SUV39H2 AGBL3 PSIP1 ZNF26 CYP4B1 PIF1 WDR67 HMMR GINS2 POLA1 CEP72 SYDE2 PKN3 TOPBP1 TRIM52 NEDD4 TACC3 TRAF5 CASP8AP2 RPL30 STMN1 KPNA2 RRM1 TMEM106C LPCAT1 MCM6 KPNA1 KIF22 CSTF1 STAG1 H2AFV KIAA0101 PLOD2 E2F1 TIMELESS MMD CCNA2 FANCA CDKN2C TEAD4 BRCA1 NEK2 HHEX ISG20 KIF23 CENPA RAD51 CCNE2 NCF4 TIMM8A PAX6 SLC25A40 PSMC3IP KIAA1009 LHX2 FOXD1 CYP4F3 SYCP2 PTP4A3 SP4 POU2F3 ZNF200 CYP7B1 LOC81691 MCM7 KIF2C AURKB RPA3 RIPK2 EED ANXA9 NUP205 SULF1 DMN ZNF473 CCNE1 TMEM48 GOLT1B COQ4 S100PBP GMCL1 KTELC1 ABHD10 MLF1IP MYO5C RPP25 DBR1 BXDC2 HSPBAP1 CENPQ FA2H CENPO ATG3 DOK3 NUP62CL CDCA3 COL8A2 XRN2 PARP9 MCM8 CDCA7 MTPN FAM33A THEX1 NOM1 TRIM59 E2F7 IRX2 ZNF367 RTKN2
GO:0005643	CC	nuclear pore	0.0984848484848485	0.266309492734949	66	4.37649701378514	CSE1L NUP155 NUP210 NUP107 KPNA2 KPNA1 NUP205 TMEM48 NUP62CL
GO:0005634	CC	nucleus	0.0438739789964994	0.194612121082996	4285	11.4671532272296	ANLN TAF5 RPS6KA5 BIRC5 NUSAP1 STAT1 DEK CSE1L PCNA TOP2A RUVBL1 SMC4 DNMT1 MYBL2 MCM5 RPA2 MCM2 FOXM1 ACTL6A LIG1 HLTF RNASEH2A MDC1 CDC2 MTF2 EZH2 TMPO PTTG1 FANCG BUB1B DLG7 VRK1 CDC6 RFC4 ZWINT TRIP13 TOE1 AURKA CDC45L RAD51AP1 NDC80 SMC2 DBF4 S100P NEFH RAD1 CDC7 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 CHAF1B MLF1 CENPE PRIM1 EXOSC9 ITGB3BP CA9 MPHOSPH1 BARD1 CHEK1 BLM POLE2 GINS1 ISL1 KNTC1 KIF14 NUP155 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ ANP32E PTTG3 HIST1H1C IFI35 KIFC1 CDT1 SPC25 TPX2 IRX5 CHEK2 MKI67 MCM4 ASXL1 NUP210 NCAPD3 NCAPH FANCI SENP5 APITD1 TWIST1 HOXD11 CCNB1 EXOSC8 HMG4L PRC1 ASF1B KIF4A DTL SUV39H1 NCAPG HJURP CENPM NUP107 FBXO5 RMI1 ORC6L USP18 TIPIN DCLRE1B DSN1 CENPN NCAPG2 STAG3 DDX25 E2F8 HELLS FANCE MCM10 MXD3 KIF18A PUS3 CDCA8 MIS12 DONSON RACGAP1 CENPK NOP5/NOP58 TCF19 NUF2 ZIC2 MND1 PCGF6 BEX2 CDCA5 C15orf23 PHF19 UHRF1 SLFN11 C6orf173 C11orf82 GEN1 SGOL2 EID3 CENPH ZNF541 ZNF280C RECQL4 KLF11 FANCM SUV39H2 PSIP1 ZNF26 PIF1 GINS2 POLA1 PKN3 TOPBP1 CASP8AP2 KPNA2 MCM6 KPNA1 KIF22 CSTF1 STAG1 H2AFV KIAA0101 E2F1 TIMELESS CCNA2 FANCA CDKN2C TEAD4 BRCA1 NEK2 HHEX ISG20 KIF23 CENPA RAD51 CCNE2 PAX6 PSMC3IP KIAA1009 LHX2 FOXD1 SYCP2 SP4 POU2F3 ZNF200 LOC81691 MCM7 KIF2C AURKB RPA3 EED NUP205 ZNF473 CCNE1 TMEM48 S100PBP GMCL1 MLF1IP RPP25 DBR1 BXDC2 CENPQ CENPO NUP62CL XRN2 PARP9 MCM8 CDCA7 NOM1 E2F7 IRX2 ZNF367
GO:0010458	BP	exit from mitosis	0.230769230769231	0.438529009653515	13	5.32671277364395	ANLN BIRC5 KNTC1
GO:0050000	BP	chromosome localization	0.833333333333333	0.408248290463863	6	14.0988007449356	BIRC5 DLG7 CENPE CENPF CDCA5
GO:0000922	CC	spindle pole	0.227272727272727	0.428932027228889	22	6.8148911559033	DLG7 KIF11 KNTC1 CENPF TPX2
GO:0000910	BP	cytokinesis	0.177419354838710	0.377456114375658	31	6.11934278765392	ANLN BIRC5 NUSAP1 PRC1 RACGAP1 AURKB
GO:0032392	BP	DNA geometric change	0.214285714285714	0.377964473009227	14	5.08989930689492	MCM2 MCM4 MCM6 RAD51
GO:0003774	MF	motor activity	0.0774647887323944	0.254712845186784	142	4.64855936080752	KIF11 CENPE MPHOSPH1 KIF14 KIFC1 KIF4A KIF20A KIF15 KIF18A KIF22 KIF23 KIF2C MYO5C
GO:0003777	MF	microtubule motor activity	0.13125	0.325535099898341	80	6.90632160279856	KIF11 CENPE MPHOSPH1 KIF14 KIFC1 KIF4A KIF20A KIF15 KIF18A KIF22 KIF23 KIF2C
GO:0032297	BP	negative regulation of DNA replication initiation	0.666666666666667	0.516397779494322	6	11.1998548304911	CDC6 CDC45L CDT1 TIPIN
GO:0051052	BP	regulation of DNA metabolic process	0.166666666666667	0.345032779671177	57	7.72715334558248	PCNA CDC6 CDC45L BLM CDT1 GMNN TIPIN PIF1 KPNA2 KPNA1 BRCA1 RAD51
GO:0051053	BP	negative regulation of DNA metabolic process	0.272727272727273	0.455842305838552	22	8.32957452663523	CDC6 CDC45L BLM CDT1 GMNN TIPIN
GO:0003697	MF	single-stranded DNA binding	0.117021276595745	0.298779509320233	47	4.59454746075131	RPA2 RAD51AP1 BLM MCM4 MCM6 RAD51 RPA3
GO:0003682	MF	chromatin binding	0.0944444444444444	0.279389829188863	90	4.84160137214698	TOP2A ACTL6A CDC6 CHAF1B CENPF SUV39H1 CDCA5 SUV39H2 POLA1 CENPA
GO:0003676	MF	nucleic acid binding	0.0322101090188305	0.166223869749928	3027	4.09842216304271	TAF5 NUSAP1 STAT1 DEK PCNA TOP2A DNMT1 MYBL2 MCM5 RPA2 MCM2 FOXM1 LIG1 HLTF RNASEH2A MTF2 EZH2 TMPO PTTG1 FANCG RFC4 TOE1 RAD51AP1 DBF4 NEFH RAD1 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 MLF1 EXOSC9 BARD1 BLM POLE2 ISL1 TAF1A APOBEC3B ZNF165 HOXC6 CDKN2A HOXD10 POLQ HIST1H1C CDT1 IRX5 MCM4 APITD1 DNA2 TWIST1 HOXD11 EXOSC8 HMG4L KIF4A HJURP RMI1 DDX60 ORC6L KIF15 ISG20L1 DDX25 E2F8 HELLS MXD3 PUS3 TCF19 ZIC2 MND1 PCGF6 PHF19 UHRF1 GEN1 ZNF541 ZNF280C RECQL4 KLF11 FANCM PSIP1 ZNF26 PIF1 POLA1 TOPBP1 C16orf75 PMS2L11 RPL30 MCM6 KIF22 CSTF1 H2AFV E2F1 TEAD4 BRCA1 HHEX ISG20 CENPA RAD51 PAX6 PSMC3IP LHX2 FOXD1 SYCP2 SP4 POU2F3 ZNF200 LOC81691 MCM7 KIF2C RPA3 ZNF473 RBM7 RPP25 XRN2 MCM8 THEX1 E2F7 IRX2 ZNF367
GO:0003677	MF	DNA binding	0.0373876005679129	0.179496322284345	2113	5.123281237317	TAF5 NUSAP1 STAT1 DEK PCNA TOP2A DNMT1 MYBL2 MCM5 RPA2 MCM2 FOXM1 LIG1 HLTF MTF2 EZH2 TMPO PTTG1 FANCG RFC4 RAD51AP1 NEFH RAD1 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 MLF1 BLM POLE2 ISL1 TAF1A ZNF165 HOXC6 CDKN2A HOXD10 POLQ HIST1H1C CDT1 IRX5 MCM4 APITD1 DNA2 TWIST1 HOXD11 HMG4L KIF4A HJURP ORC6L KIF15 E2F8 HELLS MXD3 TCF19 ZIC2 MND1 PCGF6 UHRF1 GEN1 ZNF541 ZNF280C KLF11 FANCM PSIP1 PIF1 POLA1 TOPBP1 C16orf75 PMS2L11 MCM6 KIF22 H2AFV E2F1 TEAD4 BRCA1 HHEX CENPA RAD51 PAX6 PSMC3IP LHX2 FOXD1 SYCP2 SP4 POU2F3 MCM7 KIF2C RPA3 ZNF473 MCM8 E2F7 IRX2 ZNF367
GO:0003678	MF	DNA helicase activity	0.121621621621622	0.298268275155042	37	4.2741871865159	RUVBL1 BLM MCM4 RECQL4 PIF1 MCM6
GO:0015630	CC	microtubule cytoskeleton	0.0944148936170213	0.279991767862775	376	9.98214436380027	BIRC5 CEP78 NUSAP1 TOP2A CDC25B CDC20 SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA KIF11 TTK CENPE MPHOSPH1 KNTC1 KIF14 CENPF KIFC1 TPX2 CCNB1 PRC1 KIF4A KIF20A FBXO5 KIF15 KIF18A RACGAP1 SASS6 CKAP2 CEP72 STMN1 KIF22 BRCA1 NEK2 KIF23 KIAA1009 KIF2C AURKB FAM33A
GO:0008094	MF	DNA-dependent ATPase activity	0.166666666666667	0.341565025531987	51	7.30777957142305	TOP2A MCM5 MCM2 RFC4 BLM MCM4 PIF1 MCM6 RAD51 MCM7 MCM8
GO:0032553	MF	ribonucleotide binding	0.0401978973407545	0.186796761533327	1617	5.25003891846112	RPS6KA5 TK1 TOP2A RUVBL1 SMC4 MCM5 MCM2 STCH ACTL6A LIG1 HLTF CDC2 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L TTK MELK PLK4 CENPE MPHOSPH1 CHEK1 BLM KIF14 POLQ KIFC1 ATP2C1 TPX2 CHEK2 MKI67 MCM4 DNA2 GMPS KIF4A KIF20A ATAD2 DDX60 KIF15 DDX25 HELLS KIF18A CHTF18 SLFN11 MASTL KIAA1804 GBP5 HSPA6 ACVR1C FIGNL1 RECQL4 SLFN13 FANCM PIF1 PKN3 PMS2L11 RRM1 ARAF MCM6 KIF22 NEK2 KIF23 RAD51 FASTKD2 MCM7 KIF2C AURKB RIPK2 MYO5C MCM8 DOCK11
GO:0032555	MF	purine ribonucleotide binding	0.0401978973407545	0.186796761533327	1617	5.25003891846112	RPS6KA5 TK1 TOP2A RUVBL1 SMC4 MCM5 MCM2 STCH ACTL6A LIG1 HLTF CDC2 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L TTK MELK PLK4 CENPE MPHOSPH1 CHEK1 BLM KIF14 POLQ KIFC1 ATP2C1 TPX2 CHEK2 MKI67 MCM4 DNA2 GMPS KIF4A KIF20A ATAD2 DDX60 KIF15 DDX25 HELLS KIF18A CHTF18 SLFN11 MASTL KIAA1804 GBP5 HSPA6 ACVR1C FIGNL1 RECQL4 SLFN13 FANCM PIF1 PKN3 PMS2L11 RRM1 ARAF MCM6 KIF22 NEK2 KIF23 RAD51 FASTKD2 MCM7 KIF2C AURKB RIPK2 MYO5C MCM8 DOCK11
GO:0032559	MF	adenyl ribonucleotide binding	0.0488461538461538	0.205108486720291	1300	6.96596712044112	RPS6KA5 TK1 TOP2A RUVBL1 SMC4 MCM5 MCM2 STCH ACTL6A LIG1 HLTF CDC2 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L TTK MELK PLK4 CENPE MPHOSPH1 CHEK1 BLM KIF14 POLQ KIFC1 ATP2C1 TPX2 CHEK2 MKI67 MCM4 DNA2 GMPS KIF4A KIF20A ATAD2 DDX60 KIF15 DDX25 HELLS KIF18A CHTF18 SLFN11 MASTL KIAA1804 HSPA6 ACVR1C FIGNL1 RECQL4 SLFN13 FANCM PIF1 PKN3 PMS2L11 RRM1 ARAF MCM6 KIF22 NEK2 KIF23 RAD51 FASTKD2 MCM7 KIF2C AURKB RIPK2 MYO5C MCM8
GO:0032508	BP	DNA duplex unwinding	0.214285714285714	0.377964473009227	14	5.08989930689492	MCM2 MCM4 MCM6 RAD51
GO:0006323	BP	DNA packaging	0.150943396226415	0.353012958893085	106	9.4005584675976	NUSAP1 TOP2A SMC4 MCM2 SMC2 NEFH CHAF1B HIST1H1C NCAPD3 NCAPH ASF1B NCAPG NCAPG2 HELLS CDCA5 H2AFV CENPA
GO:0006310	BP	DNA recombination	0.114583333333333	0.294503745545538	96	6.40644645135562	RUVBL1 LIG1 RAD51AP1 RAD54L EXO1 CHEK1 BLM MND1 RECQL4 KPNA2 KPNA1 BRCA1 RAD51 PSMC3IP
GO:0006302	BP	double-strand break repair	0.157142857142857	0.338061701891407	35	5.65039585838668	RAD51AP1 RAD54L FEN1 BLM POLA1 BRCA1 RAD51
GO:0051383	BP	kinetochore organization and biogenesis	1	0	4	13.8777338857343	CENPE CENPF MIS12 CENPH
GO:0051320	BP	S phase	0.2	0.376968517462526	20	5.6308748079842	CDC7 CDT1 TIPIN POLA1 TIMELESS
GO:0051321	BP	meiotic cell cycle	0.147887323943662	0.331601807219605	71	7.50191475583941	CKS2 PIM2 RAD1 RAD54L EXO1 CHEK1 STAG3 MND1 NEK2 RAD51 PSMC3IP SYCP2 RBM7
GO:0051325	BP	interphase	0.193181818181818	0.374716890693986	88	11.3813011102055	CDKN3 BIRC5 CDC2 CDC6 DBF4 CDC7 CHEK1 BLM CDKN2A CENPF CDT1 CCNB1 TIPIN CDCA5 POLA1 KPNA2 E2F1 TIMELESS CDKN2C CCNE1
GO:0051327	BP	M phase of meiotic cell cycle	0.152173913043478	0.335457850272524	69	7.64837816044606	CKS2 PIM2 RAD1 RAD54L EXO1 CHEK1 STAG3 MND1 NEK2 RAD51 PSMC3IP SYCP2 RBM7
GO:0051329	BP	interphase of mitotic cell cycle	0.186746987951807	0.372130020661330	83	10.6342110716379	CDKN3 BIRC5 CDC2 CDC6 DBF4 CDC7 CHEK1 BLM CDKN2A CENPF CDT1 CCNB1 CDCA5 POLA1 KPNA2 E2F1 CDKN2C CCNE1
GO:0051310	BP	metaphase plate congression	0.75	0.5	4	10.3274868362882	CENPE CENPF CDCA5
GO:0051319	BP	G2 phase	0.5	0.5	5	7.57742142227498	BLM CENPF KPNA2
GO:0051301	BP	cell division	0.236607142857143	0.409855171995586	224	22.8833335564318	ANLN BIRC5 NUSAP1 RUVBL1 SMC4 CDC25B CKS1B LIG1 CDC20 SPAG5 CDC2 PTTG1 BUB1B CDC6 ZWINT NDC80 CKS2 SMC2 KIF11 CDC7 CENPE MPHOSPH1 BLM KNTC1 CENPF KIFC1 SPC25 NCAPD3 NCAPH SENP5 CCNB1 PRC1 ZWILCH CEP55 NCAPG FBXO5 TIPIN DSN1 NCAPG2 HELLS CDCA8 MIS12 RACGAP1 NUF2 CDCA5 CABLES2 SGOL2 STAG1 TIMELESS CCNA2 NEK2 KIF23 CCNE2 KIAA1009 SYCP2 AURKB CCNE1 CDCA3 FAM33A
GO:0051303	BP	establishment of chromosome localization	0.833333333333333	0.408248290463863	6	14.0988007449356	BIRC5 DLG7 CENPE CENPF CDCA5
GO:0030496	CC	midbody	0.25	0.424918292799399	10	5.10328125468586	BIRC5 CDC2 AURKB
GO:0043189	CC	H4/H2A histone acetyltransferase complex	0.285714285714286	0.487950036474267	7	4.94030731260564	RUVBL1 ACTL6A
GO:0006139	BP	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0359467455621302	0.175338399754842	3380	6.12774821884204	TAF5 RPS6KA5 TK1 STAT1 DEK PCNA TOP2A RUVBL1 SMC4 DNMT1 MYBL2 MCM5 RPA2 RRM2 MCM2 DHFR FOXM1 ACTL6A LIG1 HLTF RNASEH2A MDC1 EZH2 TMPO PTTG1 FANCG CDC6 RFC4 TRIP13 CDC45L RAD51AP1 SMC2 DBF4 RAD1 RAD54L EXO1 WDHD1 PARP2 HLF NUDT1 FEN1 CHAF1B MLF1 FST PRIM1 EXOSC9 ITGB3BP BARD1 CHEK1 BLM POLE2 GINS1 ISL1 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ PTTG3 CDT1 IRX5 MCM4 ASXL1 FANCI DNA2 TWIST1 GMPS HOXD11 EXOSC8 HMG4L ASF1B GMNN DTL SUV39H1 ORC6L TIPIN DCLRE1B E2F8 HELLS FANCE MCM10 MXD3 PUS3 PRTFDC1 NOP5/NOP58 TCF19 MND1 PCGF6 PHF19 UHRF1 GEN1 EID3 ZNF280C FIGNL1 RECQL4 KLF11 FANCM SUV39H2 PSIP1 ZNF26 PIF1 GINS2 POLA1 TOPBP1 CASP8AP2 PMS2L11 KPNA2 RRM1 MCM6 KPNA1 CSTF1 E2F1 TIMELESS CCNA2 FANCA LCMT2 TEAD4 BRCA1 HHEX ISG20 RAD51 CCNE2 PAX6 PSMC3IP LHX2 FOXD1 SP4 POU2F3 ZNF200 MCM7 RPA3 RIPK2 ZNF473 CCNE1 GMCL1 MLF1IP RPP25 DBR1 XRN2 MCM8 CDCA7 THEX1 NOM1 E2F7 IRX2 ZNF367
GO:0006260	BP	DNA replication	0.170854271356784	0.360211461280348	199	14.9248530908469	TK1 PCNA TOP2A MCM5 RPA2 RRM2 MCM2 LIG1 RNASEH2A CDC6 RFC4 CDC45L DBF4 EXO1 FEN1 CHAF1B PRIM1 BLM POLE2 GINS1 POLQ CDT1 MCM4 DNA2 GMNN DTL ORC6L TIPIN MCM10 GINS2 POLA1 PMS2L11 RRM1 MCM6 RAD51 CCNE2 MCM7 RPA3 MCM8
GO:0006261	BP	DNA-dependent DNA replication	0.180412371134021	0.362180656825698	97	11.0569183744029	PCNA MCM5 RPA2 MCM2 CDC6 RFC4 CDC45L EXO1 PRIM1 BLM CDT1 MCM4 GMNN TIPIN POLA1 PMS2L11 MCM6 RAD51 CCNE2 MCM7 MCM8
GO:0006268	BP	DNA unwinding during replication	0.25	0.398862017608733	12	5.59071436699254	MCM2 MCM4 MCM6 RAD51
GO:0006259	BP	DNA metabolic process	0.134279475982533	0.324060035186347	458	17.1916248708502	TK1 PCNA TOP2A RUVBL1 SMC4 DNMT1 MCM5 RPA2 RRM2 MCM2 LIG1 RNASEH2A MDC1 PTTG1 FANCG CDC6 RFC4 CDC45L RAD51AP1 SMC2 DBF4 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B PRIM1 CHEK1 BLM POLE2 GINS1 CDKN2A POLQ PTTG3 CDT1 MCM4 FANCI DNA2 GMNN DTL ORC6L TIPIN DCLRE1B HELLS FANCE MCM10 MND1 UHRF1 GEN1 RECQL4 FANCM PIF1 GINS2 POLA1 TOPBP1 PMS2L11 KPNA2 RRM1 MCM6 KPNA1 FANCA BRCA1 ISG20 RAD51 CCNE2 PSMC3IP MCM7 RPA3 XRN2 MCM8
GO:0006281	BP	DNA repair	0.116326530612245	0.306585464494231	245	10.4779781354286	PCNA TOP2A LIG1 MDC1 PTTG1 FANCG RFC4 RAD51AP1 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B CHEK1 BLM POLE2 POLQ FANCI DCLRE1B FANCE UHRF1 GEN1 RECQL4 FANCM POLA1 TOPBP1 PMS2L11 FANCA BRCA1 RAD51 RPA3
GO:0043283	BP	biopolymer metabolic process	0.0314738441502062	0.164365840509267	4607	4.97512197149911	TAF5 RPS6KA5 TK1 STAT1 DEK PCNA TOP2A RUVBL1 SMC4 DNMT1 MYBL2 MCM5 RPA2 CDC25B RRM2 MCM2 FOXM1 ACTL6A LIG1 CDC20 HLTF RNASEH2A MDC1 CDC2 EZH2 PTTG1 FANCG BUB1B VRK1 MMP9 CDC6 RFC4 TRIP13 AURKA CDC45L RAD51AP1 SMC2 DBF4 PIM2 RAD1 CDC7 RAD54L EXO1 WDHD1 PARP2 HLF NUDT1 FEN1 CHAF1B TTK MELK PLK4 FST PRIM1 EXOSC9 ITGB3BP BARD1 CHEK1 ISG15 BLM MMP3 POLE2 GINS1 ISL1 TAF1A ZNF165 HOXC6 CDKN2A HOXD10 POLQ PRSS16 PTTG3 CXCR4 CDT1 IRX5 CHEK2 MCM4 ASXL1 FANCI SENP5 DNA2 TWIST1 HOXD11 EXOSC8 HMG4L ASF1B GMNN DTL SUV39H1 FBXO5 ORC6L USP18 TIPIN DCLRE1B HERC5 E2F8 HELLS FANCE MCM10 MXD3 PUS3 NOP5/NOP58 UBE2T TCF19 MND1 PCGF6 PHF19 UHRF1 GEN1 MASTL KIAA1804 EID3 ZNF280C PIGX ACVR1C RECQL4 KLF11 FANCM SUV39H2 PSIP1 ZNF26 PIF1 GINS2 ZYG11A POLA1 PKN3 TOPBP1 NEDD4 CASP8AP2 PMS2L11 KPNA2 RRM1 ARAF MCM6 KPNA1 CSTF1 PLOD2 E2F1 TIMELESS FANCA LCMT2 TEAD4 BRCA1 NEK2 HHEX ISG20 RAD51 CCNE2 PAX6 PSMC3IP LHX2 FOXD1 PTP4A3 SP4 POU2F3 ZNF200 MCM7 AURKB RPA3 RIPK2 ZNF473 CCNE1 MLF1IP RPP25 DBR1 WDR5B ATG3 CDCA3 XRN2 MCM8 CDCA7 NOM1 ASB2 E2F7 IRX2 ZNF367 PPIL5
GO:0006270	BP	DNA replication initiation	0.351851851851852	0.434449581362946	27	12.1505660297135	MCM5 MCM2 CDC6 CDC45L CDT1 MCM4 TIPIN POLA1 MCM6 CCNE2 MCM7 MCM8
GO:0030174	BP	regulation of DNA replication initiation	0.5	0.534522483824849	8	9.5856636793214	CDC6 CDC45L CDT1 TIPIN
GO:0006275	BP	regulation of DNA replication	0.25	0.440958551844098	28	8.54423606247044	PCNA CDC6 CDC45L BLM CDT1 GMNN TIPIN
GO:0043226	CC	organelle	0.0312125648875283	0.164562322313371	7513	7.14128658599286	ANLN TAF5 RPS6KA5 FILIP1L BIRC5 CEP78 MPHOSPH9 TMEM22 NUSAP1 STAT1 DEK CSE1L PCNA TOP2A IFI30 RUVBL1 INSIG1 SMC4 DNMT1 MYBL2 MCM5 RPA2 MTHFD2 CDC25B MCM2 STCH FOXM1 ACTL6A LIG1 CDC20 HLTF RNASEH2A MDC1 SPAG5 CDC2 MTF2 EZH2 TMPO LSP1 PTTG1 FANCG BUB1B DLG7 VRK1 CDC6 RFC4 ZWINT TRIP13 TOE1 AURKA CDC45L RAD51AP1 NDC80 SMC2 DBF4 S100P NEFH APOC1 KIF11 RAD1 BID CDC7 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 CHAF1B MLF1 TTK CENPE PRIM1 EXOSC9 ITGB3BP CA9 MPHOSPH1 BARD1 CHEK1 LAMP3 RASGRP1 CYP27B1 BLM POLE2 GINS1 ISL1 NTS KNTC1 KIF14 ABAT NUP155 TAF1A KRT31 ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ ANP32E PRSS16 PTTG3 HIST1H1C IFI35 KIFC1 CDT1 SPC25 ATP2C1 NCF2 TPX2 RPL39L IRX5 CHEK2 MKI67 MCM4 ASXL1 NUP210 NCAPD3 NCAPH FANCI SENP5 APITD1 TWIST1 HOXD11 CCNB1 EXOSC8 HMG4L PRC1 ASF1B ZWILCH KIF4A DTL SUV39H1 NCAPG HJURP CENPM KIF20A NUP107 FBXO5 RMI1 ORC6L USP18 TIPIN KIF15 C3orf52 DCLRE1B DSN1 CENPN NCAPG2 SLC15A3 STAG3 DDX25 E2F8 HELLS FANCE MCM10 MXD3 KIF18A PUS3 CDCA8 MIS12 DONSON RACGAP1 CENPK NOP5/NOP58 SLC25A19 TCF19 NUF2 ZIC2 MND1 PCGF6 BEX2 CDCA5 C15orf23 PHF19 UHRF1 SLFN11 C6orf173 C11orf82 GEN1 SGOL2 EID3 CENPH KRT80 SASS6 ZNF541 ZNF280C PIGX ALG10 RECQL4 KLF11 CKAP2 FANCM SUV39H2 PSIP1 ZNF26 CYP4B1 PIF1 GINS2 POLA1 CEP72 PKN3 TOPBP1 CASP8AP2 RPL30 STMN1 KPNA2 TMEM106C LPCAT1 MCM6 KPNA1 KIF22 CSTF1 STAG1 H2AFV KIAA0101 PLOD2 E2F1 TIMELESS MMD CCNA2 FANCA CDKN2C TEAD4 BRCA1 NEK2 HHEX ISG20 KIF23 CENPA RAD51 CCNE2 TIMM8A PAX6 SLC25A40 PSMC3IP KIAA1009 LHX2 FOXD1 CYP4F3 SYCP2 PTP4A3 SP4 POU2F3 ZNF200 CYP7B1 LOC81691 MCM7 KIF2C AURKB RPA3 EED NUP205 SULF1 DMN ZNF473 CCNE1 TMEM48 GOLT1B COQ4 S100PBP GMCL1 KTELC1 ABHD10 MLF1IP MYO5C RPP25 DBR1 BXDC2 CENPQ FA2H CENPO NUP62CL XRN2 PARP9 MCM8 CDCA7 FAM33A NOM1 E2F7 IRX2 ZNF367
GO:0043227	CC	membrane-bound organelle	0.032364895378594	0.167361490905169	6643	7.26709209180785	ANLN TAF5 RPS6KA5 BIRC5 MPHOSPH9 TMEM22 NUSAP1 STAT1 DEK CSE1L PCNA TOP2A IFI30 RUVBL1 INSIG1 SMC4 DNMT1 MYBL2 MCM5 RPA2 MTHFD2 MCM2 STCH FOXM1 ACTL6A LIG1 HLTF RNASEH2A MDC1 CDC2 MTF2 EZH2 TMPO PTTG1 FANCG BUB1B DLG7 VRK1 CDC6 RFC4 ZWINT TRIP13 TOE1 AURKA CDC45L RAD51AP1 NDC80 SMC2 DBF4 S100P NEFH APOC1 RAD1 BID CDC7 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 CHAF1B MLF1 CENPE PRIM1 EXOSC9 ITGB3BP CA9 MPHOSPH1 BARD1 CHEK1 LAMP3 RASGRP1 CYP27B1 BLM POLE2 GINS1 ISL1 KNTC1 KIF14 ABAT NUP155 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ ANP32E PTTG3 HIST1H1C IFI35 KIFC1 CDT1 SPC25 ATP2C1 NCF2 TPX2 IRX5 CHEK2 MKI67 MCM4 ASXL1 NUP210 NCAPD3 NCAPH FANCI SENP5 APITD1 TWIST1 HOXD11 CCNB1 EXOSC8 HMG4L PRC1 ASF1B KIF4A DTL SUV39H1 NCAPG HJURP CENPM KIF20A NUP107 FBXO5 RMI1 ORC6L USP18 TIPIN C3orf52 DCLRE1B DSN1 CENPN NCAPG2 SLC15A3 STAG3 DDX25 E2F8 HELLS FANCE MCM10 MXD3 KIF18A PUS3 CDCA8 MIS12 DONSON RACGAP1 CENPK NOP5/NOP58 SLC25A19 TCF19 NUF2 ZIC2 MND1 PCGF6 BEX2 CDCA5 C15orf23 PHF19 UHRF1 SLFN11 C6orf173 C11orf82 GEN1 SGOL2 EID3 CENPH ZNF541 ZNF280C PIGX ALG10 RECQL4 KLF11 FANCM SUV39H2 PSIP1 ZNF26 CYP4B1 PIF1 GINS2 POLA1 PKN3 TOPBP1 CASP8AP2 KPNA2 TMEM106C LPCAT1 MCM6 KPNA1 KIF22 CSTF1 STAG1 H2AFV KIAA0101 PLOD2 E2F1 TIMELESS MMD CCNA2 FANCA CDKN2C TEAD4 BRCA1 NEK2 HHEX ISG20 KIF23 CENPA RAD51 CCNE2 TIMM8A PAX6 SLC25A40 PSMC3IP KIAA1009 LHX2 FOXD1 CYP4F3 SYCP2 PTP4A3 SP4 POU2F3 ZNF200 CYP7B1 LOC81691 MCM7 KIF2C AURKB RPA3 EED NUP205 SULF1 ZNF473 CCNE1 TMEM48 GOLT1B COQ4 S100PBP GMCL1 KTELC1 ABHD10 MLF1IP RPP25 DBR1 BXDC2 CENPQ FA2H CENPO NUP62CL XRN2 PARP9 MCM8 CDCA7 NOM1 E2F7 IRX2 ZNF367
GO:0043228	CC	non-membrane-bound organelle	0.059342665855143	0.226131058976459	1643	11.1131510193370	ANLN TAF5 FILIP1L BIRC5 CEP78 NUSAP1 PCNA TOP2A SMC4 DNMT1 MYBL2 RPA2 CDC25B MCM2 CDC20 SPAG5 CDC2 TMPO LSP1 BUB1B DLG7 CDC6 RFC4 ZWINT AURKA NDC80 SMC2 NEFH KIF11 TTK CENPE PRIM1 EXOSC9 ITGB3BP MPHOSPH1 CHEK1 BLM KNTC1 KIF14 TAF1A KRT31 CDKN2A CENPF HIST1H1C KIFC1 CDT1 SPC25 TPX2 RPL39L MKI67 NCAPD3 FANCI APITD1 CCNB1 HMG4L PRC1 ASF1B ZWILCH KIF4A SUV39H1 CENPM KIF20A FBXO5 ORC6L TIPIN KIF15 DSN1 CENPN STAG3 HELLS KIF18A CDCA8 MIS12 RACGAP1 CENPK NOP5/NOP58 NUF2 CDCA5 SGOL2 CENPH KRT80 SASS6 CKAP2 SUV39H2 PIF1 POLA1 CEP72 TOPBP1 RPL30 STMN1 KIF22 H2AFV TIMELESS BRCA1 NEK2 KIF23 CENPA RAD51 KIAA1009 SYCP2 LOC81691 MCM7 KIF2C AURKB RPA3 DMN MLF1IP MYO5C CENPQ CENPO XRN2 FAM33A NOM1
GO:0043229	CC	intracellular organelle	0.0312250332889481	0.164594009207682	7510	7.14913140723862	ANLN TAF5 RPS6KA5 FILIP1L BIRC5 CEP78 MPHOSPH9 TMEM22 NUSAP1 STAT1 DEK CSE1L PCNA TOP2A IFI30 RUVBL1 INSIG1 SMC4 DNMT1 MYBL2 MCM5 RPA2 MTHFD2 CDC25B MCM2 STCH FOXM1 ACTL6A LIG1 CDC20 HLTF RNASEH2A MDC1 SPAG5 CDC2 MTF2 EZH2 TMPO LSP1 PTTG1 FANCG BUB1B DLG7 VRK1 CDC6 RFC4 ZWINT TRIP13 TOE1 AURKA CDC45L RAD51AP1 NDC80 SMC2 DBF4 S100P NEFH APOC1 KIF11 RAD1 BID CDC7 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 CHAF1B MLF1 TTK CENPE PRIM1 EXOSC9 ITGB3BP CA9 MPHOSPH1 BARD1 CHEK1 LAMP3 RASGRP1 CYP27B1 BLM POLE2 GINS1 ISL1 NTS KNTC1 KIF14 ABAT NUP155 TAF1A KRT31 ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ ANP32E PRSS16 PTTG3 HIST1H1C IFI35 KIFC1 CDT1 SPC25 ATP2C1 NCF2 TPX2 RPL39L IRX5 CHEK2 MKI67 MCM4 ASXL1 NUP210 NCAPD3 NCAPH FANCI SENP5 APITD1 TWIST1 HOXD11 CCNB1 EXOSC8 HMG4L PRC1 ASF1B ZWILCH KIF4A DTL SUV39H1 NCAPG HJURP CENPM KIF20A NUP107 FBXO5 RMI1 ORC6L USP18 TIPIN KIF15 C3orf52 DCLRE1B DSN1 CENPN NCAPG2 SLC15A3 STAG3 DDX25 E2F8 HELLS FANCE MCM10 MXD3 KIF18A PUS3 CDCA8 MIS12 DONSON RACGAP1 CENPK NOP5/NOP58 SLC25A19 TCF19 NUF2 ZIC2 MND1 PCGF6 BEX2 CDCA5 C15orf23 PHF19 UHRF1 SLFN11 C6orf173 C11orf82 GEN1 SGOL2 EID3 CENPH KRT80 SASS6 ZNF541 ZNF280C PIGX ALG10 RECQL4 KLF11 CKAP2 FANCM SUV39H2 PSIP1 ZNF26 CYP4B1 PIF1 GINS2 POLA1 CEP72 PKN3 TOPBP1 CASP8AP2 RPL30 STMN1 KPNA2 TMEM106C LPCAT1 MCM6 KPNA1 KIF22 CSTF1 STAG1 H2AFV KIAA0101 PLOD2 E2F1 TIMELESS MMD CCNA2 FANCA CDKN2C TEAD4 BRCA1 NEK2 HHEX ISG20 KIF23 CENPA RAD51 CCNE2 TIMM8A PAX6 SLC25A40 PSMC3IP KIAA1009 LHX2 FOXD1 CYP4F3 SYCP2 PTP4A3 SP4 POU2F3 ZNF200 CYP7B1 LOC81691 MCM7 KIF2C AURKB RPA3 EED NUP205 SULF1 DMN ZNF473 CCNE1 TMEM48 GOLT1B COQ4 S100PBP GMCL1 KTELC1 ABHD10 MLF1IP MYO5C RPP25 DBR1 BXDC2 CENPQ FA2H CENPO NUP62CL XRN2 PARP9 MCM8 CDCA7 FAM33A NOM1 E2F7 IRX2 ZNF367
GO:0043231	CC	intracellular membrane-bound organelle	0.0323746423731366	0.167385751312458	6641	7.27259576738245	ANLN TAF5 RPS6KA5 BIRC5 MPHOSPH9 TMEM22 NUSAP1 STAT1 DEK CSE1L PCNA TOP2A IFI30 RUVBL1 INSIG1 SMC4 DNMT1 MYBL2 MCM5 RPA2 MTHFD2 MCM2 STCH FOXM1 ACTL6A LIG1 HLTF RNASEH2A MDC1 CDC2 MTF2 EZH2 TMPO PTTG1 FANCG BUB1B DLG7 VRK1 CDC6 RFC4 ZWINT TRIP13 TOE1 AURKA CDC45L RAD51AP1 NDC80 SMC2 DBF4 S100P NEFH APOC1 RAD1 BID CDC7 RAD54L EXO1 WDHD1 PARP2 HLF FEN1 CHAF1B MLF1 CENPE PRIM1 EXOSC9 ITGB3BP CA9 MPHOSPH1 BARD1 CHEK1 LAMP3 RASGRP1 CYP27B1 BLM POLE2 GINS1 ISL1 KNTC1 KIF14 ABAT NUP155 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ ANP32E PTTG3 HIST1H1C IFI35 KIFC1 CDT1 SPC25 ATP2C1 NCF2 TPX2 IRX5 CHEK2 MKI67 MCM4 ASXL1 NUP210 NCAPD3 NCAPH FANCI SENP5 APITD1 TWIST1 HOXD11 CCNB1 EXOSC8 HMG4L PRC1 ASF1B KIF4A DTL SUV39H1 NCAPG HJURP CENPM KIF20A NUP107 FBXO5 RMI1 ORC6L USP18 TIPIN C3orf52 DCLRE1B DSN1 CENPN NCAPG2 SLC15A3 STAG3 DDX25 E2F8 HELLS FANCE MCM10 MXD3 KIF18A PUS3 CDCA8 MIS12 DONSON RACGAP1 CENPK NOP5/NOP58 SLC25A19 TCF19 NUF2 ZIC2 MND1 PCGF6 BEX2 CDCA5 C15orf23 PHF19 UHRF1 SLFN11 C6orf173 C11orf82 GEN1 SGOL2 EID3 CENPH ZNF541 ZNF280C PIGX ALG10 RECQL4 KLF11 FANCM SUV39H2 PSIP1 ZNF26 CYP4B1 PIF1 GINS2 POLA1 PKN3 TOPBP1 CASP8AP2 KPNA2 TMEM106C LPCAT1 MCM6 KPNA1 KIF22 CSTF1 STAG1 H2AFV KIAA0101 PLOD2 E2F1 TIMELESS MMD CCNA2 FANCA CDKN2C TEAD4 BRCA1 NEK2 HHEX ISG20 KIF23 CENPA RAD51 CCNE2 TIMM8A PAX6 SLC25A40 PSMC3IP KIAA1009 LHX2 FOXD1 CYP4F3 SYCP2 PTP4A3 SP4 POU2F3 ZNF200 CYP7B1 LOC81691 MCM7 KIF2C AURKB RPA3 EED NUP205 SULF1 ZNF473 CCNE1 TMEM48 GOLT1B COQ4 S100PBP GMCL1 KTELC1 ABHD10 MLF1IP RPP25 DBR1 BXDC2 CENPQ FA2H CENPO NUP62CL XRN2 PARP9 MCM8 CDCA7 NOM1 E2F7 IRX2 ZNF367
GO:0043232	CC	intracellular non-membrane-bound organelle	0.059342665855143	0.226131058976459	1643	11.1131510193370	ANLN TAF5 FILIP1L BIRC5 CEP78 NUSAP1 PCNA TOP2A SMC4 DNMT1 MYBL2 RPA2 CDC25B MCM2 CDC20 SPAG5 CDC2 TMPO LSP1 BUB1B DLG7 CDC6 RFC4 ZWINT AURKA NDC80 SMC2 NEFH KIF11 TTK CENPE PRIM1 EXOSC9 ITGB3BP MPHOSPH1 CHEK1 BLM KNTC1 KIF14 TAF1A KRT31 CDKN2A CENPF HIST1H1C KIFC1 CDT1 SPC25 TPX2 RPL39L MKI67 NCAPD3 FANCI APITD1 CCNB1 HMG4L PRC1 ASF1B ZWILCH KIF4A SUV39H1 CENPM KIF20A FBXO5 ORC6L TIPIN KIF15 DSN1 CENPN STAG3 HELLS KIF18A CDCA8 MIS12 RACGAP1 CENPK NOP5/NOP58 NUF2 CDCA5 SGOL2 CENPH KRT80 SASS6 CKAP2 SUV39H2 PIF1 POLA1 CEP72 TOPBP1 RPL30 STMN1 KIF22 H2AFV TIMELESS BRCA1 NEK2 KIF23 CENPA RAD51 KIAA1009 SYCP2 LOC81691 MCM7 KIF2C AURKB RPA3 DMN MLF1IP MYO5C CENPQ CENPO XRN2 FAM33A NOM1
GO:0043234	CC	protein complex	0.0386612810155799	0.183640523579812	1733	4.97619689274444	TAF5 FILIP1L BIRC5 CSE1L PCNA TOP2A ENO2 RUVBL1 SMC4 RPA2 MCM2 ACTL6A C1QB MDC1 EZH2 BUB1B RFC4 ZWINT SMC2 NEFH KIF11 CHAF1B CENPE PRIM1 EXOSC9 MPHOSPH1 BARD1 PLA2G7 MICB KIF14 ABAT NUP155 TAF1A CENPF HIST1H1C KIFC1 NUP210 NCAPD3 EXOSC8 ZWILCH KIF4A KIF20A NUP107 ORC6L KIF15 DSN1 E2F8 KIF18A CDCA8 MIS12 ZIC2 PCGF6 CDCA5 SGOL2 CENPH ACVR1C OSMR POLA1 KPNA2 RRM1 KPNA1 KIF22 H2AFV E2F1 BRCA1 KIF23 CENPA NCF4 TIMM8A MCM7 KIF2C RPA3 EED NUP205 TMEM48 MYO5C ATG3 NUP62CL E2F7
GO:0051276	BP	chromosome organization and biogenesis	0.105113636363636	0.300098727603511	352	11.091924198802	TAF5 RPS6KA5 NUSAP1 TOP2A RUVBL1 SMC4 MCM2 ACTL6A HLTF EZH2 PTTG1 DLG7 ZWINT NDC80 SMC2 NEFH CHAF1B CENPE BLM CENPF PTTG3 HIST1H1C KIFC1 NCAPD3 NCAPH ASF1B SUV39H1 NCAPG NCAPG2 STAG3 HELLS MIS12 CDCA5 CENPH RECQL4 SUV39H2 PIF1 H2AFV CENPA SYCP2
GO:0030261	BP	chromosome condensation	0.45	0.51041778553404	20	13.5734440563149	NUSAP1 TOP2A SMC4 SMC2 NCAPD3 NCAPH NCAPG NCAPG2 CDCA5
GO:0008408	MF	3'-5' exonuclease activity	0.173913043478261	0.357029908734864	23	5.15014615196935	RAD1 EXOSC9 EXOSC8 ISG20 THEX1
GO:0008409	MF	5'-3' exonuclease activity	0.625	0.478713553878169	4	8.55236331156517	EXO1 FEN1 XRN2
GO:0008156	BP	negative regulation of DNA replication	0.352941176470588	0.492592183071889	17	9.6702633484225	CDC6 CDC45L BLM CDT1 GMNN TIPIN
GO:0022402	BP	cell cycle process	0.182151589242054	0.367755868648162	409	23.1835464985205	ANLN CDKN3 BIRC5 MPHOSPH9 NUSAP1 RUVBL1 SMC4 CDC25B CDC20 SPAG5 CDC2 PTTG1 BUB1B DLG7 CDC6 ZWINT AURKA NDC80 CKS2 SMC2 DBF4 PIM2 KIF11 RAD1 CDC7 RAD54L EXO1 MLF1 TTK CENPE MPHOSPH1 BARD1 CHEK1 BLM KNTC1 CDKN2A CENPF KIFC1 CDT1 SPC25 TPX2 NCAPD3 NCAPH CCNB1 PRC1 ZWILCH CEP55 NCAPG FBXO5 TIPIN KIF15 DSN1 NCAPG2 STAG3 HELLS CDCA8 MIS12 RACGAP1 NUF2 MND1 CDCA5 C11orf82 SASS6 RECQL4 POLA1 STMN1 KPNA2 KIF22 STAG1 E2F1 TIMELESS CCNA2 CDKN2C BRCA1 NEK2 KIF23 RAD51 PSMC3IP KIAA1009 SYCP2 KIF2C AURKB CCNE1 RBM7 CDCA3 FAM33A
GO:0022403	BP	cell cycle phase	0.198795180722892	0.380330267006024	332	23.0118556240278	ANLN CDKN3 BIRC5 MPHOSPH9 NUSAP1 RUVBL1 SMC4 CDC25B CDC20 SPAG5 CDC2 PTTG1 BUB1B DLG7 CDC6 ZWINT AURKA NDC80 CKS2 SMC2 DBF4 PIM2 KIF11 RAD1 CDC7 RAD54L EXO1 CENPE MPHOSPH1 CHEK1 BLM KNTC1 CDKN2A CENPF KIFC1 CDT1 SPC25 TPX2 NCAPD3 NCAPH CCNB1 ZWILCH CEP55 NCAPG FBXO5 TIPIN KIF15 DSN1 NCAPG2 STAG3 HELLS CDCA8 MIS12 NUF2 MND1 CDCA5 POLA1 KPNA2 KIF22 STAG1 E2F1 TIMELESS CCNA2 CDKN2C NEK2 KIF23 RAD51 PSMC3IP KIAA1009 SYCP2 KIF2C AURKB CCNE1 RBM7 CDCA3 FAM33A
GO:0016020	CC	membrane	0.0130096121975472	0.106344988890437	6034	-6.81643387521088	PIGX ALG10 ACVR1C OSMR CYP4B1 POLA1 CNTLN KPNA2 TMEM106C LPCAT1 KPNA1 PLSCR1 PLOD2 MMD TMEFF1 NCF4 CELSR3 TIMM8A IL1RAP CD38 SLC25A40 CYP4F3 PTP4A3 CYP7B1 P2RY1 NUP205 TMEM194 FPRL2 TMEM48 GOLT1B FLRT3 SLAMF8 FA2H NUP62CL AADACL1 TMEM68 TRIM59 HS6ST2 KIAA1524 CLEC2B SLC16A1 MPHOSPH9 TMEM22 CSE1L PCNA ENO2 RUVBL1 INSIG1 CD14 ACTL6A RGS1 MDC1 TMPO LSP1 CD163 MRC1 BID SELL CCR1 CA9 KIAA0133 LAMP3 RASGRP1 LY75 CYP27B1 SYNGR3 ADAMDEC1 SELE MICB NUP155 LY96 GPR19 CENPF CXCR4 ATP2C1 TMEM97 NUP210 PAQR4 LPPR4 CCL8 SLC38A6 FAM69A NUP107 NETO2 CKLF C3orf52 SLC15A3 TMEM180 FICD SLC25A19 TNFSF13B ZIC2 ZDHHC23 C1orf162 ALG10B GBP5 TMEM71
GO:0016021	CC	integral to membrane	0.0131103074141049	0.106045607405954	4424	-5.35931038309538	PIGX ALG10 ACVR1C OSMR KPNA2 TMEM106C LPCAT1 KPNA1 PLSCR1 MMD TMEFF1 NCF4 CELSR3 IL1RAP CD38 SLC25A40 CYP4F3 P2RY1 NUP205 TMEM194 FPRL2 TMEM48 GOLT1B FLRT3 SLAMF8 FA2H NUP62CL AADACL1 TMEM68 TRIM59 HS6ST2 KIAA1524 CLEC2B SLC16A1 TMEM22 CSE1L INSIG1 TMPO CD163 MRC1 SELL CCR1 CA9 KIAA0133 LAMP3 LY75 SYNGR3 ADAMDEC1 SELE NUP155 GPR19 CXCR4 ATP2C1 TMEM97 NUP210 PAQR4 LPPR4 SLC38A6 FAM69A NUP107 NETO2 CKLF C3orf52 SLC15A3 TMEM180 FICD SLC25A19 TNFSF13B ZIC2 ZDHHC23 C1orf162 ALG10B TMEM71
GO:0051726	BP	regulation of cell cycle	0.117437722419929	0.314100502342701	281	11.3676858957265	ANLN CDKN3 BIRC5 NUSAP1 CKS1B CDC2 FANCG BUB1B DLG7 CDC6 ZWINT CDC45L CKS2 RAD1 CDC7 TTK MPHOSPH1 CHEK1 BLM KNTC1 CDKN2A CENPF CDT1 CHEK2 ZWILCH GMNN FBXO5 TIPIN HERC5 CABLES2 TIMELESS CCNA2 CDKN2C BRCA1 NEK2 CCNE2
GO:0016043	BP	cellular component organization and biogenesis	0.0378296584522265	0.183605641320848	2313	5.56251462338421	ANLN TAF5 RPS6KA5 BIRC5 NUSAP1 STAT1 CSE1L PCNA TOP2A RUVBL1 SMC4 CD14 MCM2 ACTL6A HLTF SPAG5 EZH2 PTTG1 BUB1B DLG7 MMP9 ZWINT AURKA NDC80 CKS2 SMC2 PIM2 NEFH MRC1 KIF11 BID CHAF1B TTK CENPE EXOSC9 MPHOSPH1 BARD1 LY75 BLM KNTC1 KIF14 NUP155 CDKN2A CENPF PTTG3 CXCR4 HIST1H1C KIFC1 ATP2C1 NUP210 NCAPD3 NCAPH CCL8 EXOSC8 PRC1 ASF1B KIF4A SUV39H1 NCAPG KIF20A NUP107 CKLF KIF15 NCAPG2 STAG3 DDX25 HELLS KIF18A MIS12 RACGAP1 NOP5/NOP58 TNFSF13B CDCA5 CENPH SASS6 RECQL4 SUV39H2 PIF1 STMN1 KPNA2 KPNA1 KIF22 PLSCR1 H2AFV FANCA BRCA1 HHEX KIF23 CENPA RAD51 TIMM8A IL1RAP PAX6 SYCP2 KIF2C NUP205 TMEM48 BXDC2 COL8A2 XRN2
GO:0035267	CC	NuA4 histone acetyltransferase complex	0.333333333333333	0.516397779494322	6	5.40196300160203	RUVBL1 ACTL6A