GOname	GO	GO.term	set.means	set.sd	n.genes	z.score	lead.genes
GO:0008283	BP	cell proliferation	0.0727023319615912	0.240611561722758	729	4.7011398701885	CDKN3 WARS RBBP7 NUDC BUB3 DKC1 INSIG1 CDC25B CKS1B CDK4 ADM HCLS1 BUB1B DLG7 CDC6 PIM2 CDC7 CHEK1 LAMP3 WNT2 BLM GINS1 CDKN2A CENPF IL15RA TNFSF4 MDK CXCR4 VEGFC TPX2 RBBP4 MKI67 CKLF SPHK1 TIPIN KIF15 TCF19 UHRF1 KISS1R RECQL4 KLF11 OSMR PTHLH POLA1 TXNRD1 CCDC88A TRAF5 CSE1L MFN2 SHC1 E2F1 TIMELESS CUL2 CDKN2C HHEX ISG20 PAX6 IFI16 DDX11 KIF2C RIPK2 VEGFA CDV3 BCAT1 APPL1 APPL2 FGG
GO:0008278	CC	cohesin complex	0.4	0.547722557505166	5	4.34991872567081	CDCA5 SGOL2
GO:0030867	CC	rough endoplasmic reticulum membrane	0.35	0.474341649025257	10	5.29495544565358	PLOD3 PLOD2 ARL6IP1 RPN1
GO:0030554	MF	adenyl nucleotide binding	0.0662299854439592	0.233677760900041	1374	5.23408737096602	ACVR1C TK1 EIF4A2 PAK2 ABCF1 ILF2 WARS SEPHS2 AARS TOP2A DDX23 MCM3 RUVBL1 MCM2 ERCC3 CDK4 ABCF3 STCH ACTL6A LIG1 HLTF MTRR CDC2 RPS6KA1 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L NEK2 KIF23 MELK PLK4 CENPE CHEK1 BLM KIF14 POLQ NVL PRKDC HARS2 TOR1B KIFC1 ATP2C1 TPX2 CHEK2 HSPA2 MKI67 ATP13A3 SUPV3L1 DDX12 DNA2 GMPS KIF4A KIF20A ATAD2 SPHK1 KIF15 DDX47 KIF18A ZNFX1 CHTF18 SLFN11 KIAA1804 NLRP7 RECQL4 SLFN13 FANCM TBK1 PIF1 PKN3 TXNRD1 PMS2L11 DHX15 SMC4 MCM5 ARAF FARSA KIF22 MSH6 CHD1 RECQL ASS1 CASK DDX11 MCM7 KIF2C AURKB RIPK2 YARS MCM4 WEE1 PMS2L1 PMS2L2 TOR3A SMC6 MYO5C KIF18B MCM8 AIFM2 INOC1 EEF2K ATP11C TOR2A ALPK2
GO:0051656	BP	establishment of organelle localization	0.260869565217391	0.448977758544880	23	5.7137079004863	BIRC5 NUSAP1 DLG7 CENPE CENPF CDCA5
GO:0004386	MF	helicase activity	0.125	0.306553127767252	140	5.3920455968353	EIF4A2 DDX23 RUVBL1 ERCC3 HLTF RAD54L BLM POLQ SUPV3L1 DDX12 DNA2 DDX47 CHTF18 RECQL4 FANCM PIF1 DHX15 CHD1 RECQL DDX11 MCM4 INOC1
GO:0051640	BP	organelle localization	0.203125	0.398775848590853	32	4.96820795617615	BIRC5 NUSAP1 DLG7 CENPE CENPF CDCA5 MFN2
GO:0000096	BP	sulfur amino acid metabolic process	0.225	0.412788973740948	20	4.45709125047687	CBS SEPHS2 SMS MTRR MTR
GO:0000097	BP	sulfur amino acid biosynthetic process	0.269230769230769	0.438529009653515	13	4.45782745624267	CBS SEPHS2 MTRR MTR
GO:0000082	BP	G1/S transition of mitotic cell cycle	0.25	0.394085054655756	34	6.6052587938127	CDKN3 CDK4 DBF4 CDC7 CDKN2A CDCA5 CUL2 CDKN2C INHBA CCNE1 BCAT1
GO:0000085	BP	G2 phase of mitotic cell cycle	0.4	0.547722557505166	5	4.34991872567081	BLM CENPF
GO:0000087	BP	M phase of mitotic cell cycle	0.230769230769231	0.401826006780309	208	14.9132253871291	ANLN BIRC5 TARDBP MPHOSPH9 NUSAP1 NUDC BUB3 RUVBL1 CDC25B CDC20 UBE2C SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA NDC80 SMC2 KIF11 NEK2 KIF23 CENPE KNTC1 CENPF KIFC1 SPC25 TPX2 NCAPD3 NCAPH ZWILCH CEP55 FBXO5 TIPIN KIF15 DSN1 NCAPG2 TCF7L1 CDCA8 NUF2 CDCA5 MAD2L1 RAD21 SHC1 SMC4 KIF22 STAG1 TIMELESS DDX11 KIF2C AURKB WEE1 NCAPG TXNL4B CDCA3
GO:0000070	BP	mitotic sister chromatid segregation	0.431034482758621	0.476672580256588	29	11.3910115914422	NUSAP1 BUB3 DLG7 NDC80 SMC2 CENPE KIFC1 NCAPD3 NCAPH NCAPG2 CDCA5 SMC4 DDX11 NCAPG
GO:0000075	BP	cell cycle checkpoint	0.318965517241379	0.455938167765286	58	11.4870682556548	BIRC5 BUB3 ERCC3 FANCG BUB1B CDC6 CDC45L RAD1 CHEK1 BLM KNTC1 CDKN2A CENPF ATR CHEK2 ZWILCH TIPIN MAD2L1 CCNE2 CDT1
GO:0000076	BP	DNA replication checkpoint	0.583333333333333	0.491596040125088	6	7.20102982987036	CDC6 CDC45L TIPIN CDT1
GO:0000077	BP	DNA damage checkpoint	0.230769230769231	0.42966892442366	26	5.24248147893194	RAD1 CHEK1 BLM ATR CHEK2 TIPIN
GO:0000079	BP	regulation of cyclin-dependent protein kinase activity	0.156862745098039	0.353414715008181	51	4.48128286212981	CDKN3 CKS1B CDC6 CHEK1 BLM CDKN2A HERC5 CDKN2C CCNE2
GO:0006996	BP	organelle organization and biogenesis	0.0758556891766883	0.247730127744165	1081	6.37414569544489	ANLN TAF5 CBX3 NUSAP1 LASP1 RBBP7 HDAC1 TOP2A BUB3 DKC1 RUVBL1 PSRC1 MCM2 ACTL6A UBE2C HLTF SPAG5 EZH2 BUB1B DLG7 AURKA NDC80 WASF1 SMC2 PIM2 NEFH KIF11 BID KIF23 CHAF1B CENPA CENPE EXOSC9 CCL3 WNT2 BLM KIF14 CDKN2A CENPF PTTG3 HMGN2 KIFC1 ATP2C1 RBBP4 NCAPD3 NCAPH PRC1 TMEM48 ASF1B KIF4A C20orf20 SUV39H1 KIF20A KIF15 NCAPG2 STAG3 BANP TCF7L1 KIF18A CDCA5 HPS3 CENPH SASS6 NEXN RECQL4 SUV39H2 CKAP5 PIF1 RBM14 EXOSC10 CCDC88A FAT CP110 STMN1 PSAP GOLGB1 MFN2 SMC4 AIP KIF22 TRRAP CHD1 HIRIP3 SLC25A14 TTF1 PEX10 SYCP2 DDX11 UCP2 KIF2C SLC25A17 FCF1 SUPT16H WBP11 NCAPG UTP6 BXDC2 KIF18B DTNBP1 AIFM2 INOC1
GO:0006950	BP	response to stress	0.0774647887323944	0.246904728350386	994	6.37859962259163	ABCF1 NONO AKR1B1 TOP2A ELF3 CD14 ERCC3 USP1 PLSCR1 PLOD2 LIG1 ADM C1QB MDC1 FANCG CD163 CX3CL1 PDIA5 RFC4 RAD51AP1 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B AOC3 TLR2 CCL3 BARD1 CHEK1 BLM POLE2 PLA2G7 MICB LY96 POLQ PARP1 PRKDC MDK CXCR4 TOR1B ATR CHEK2 PLAUR HSPA2 PXDN DTL TIPIN DCLRE1B FANCE C1QC UHRF1 CREB3L4 GEN1 RECQL4 FANCM TYMS PLA2G4C RBM14 POLA1 TXNRD1 TOPBP1 NCOA6 PMS2L11 RAD21 DNAJA1 VAPB GPX2 MSH6 TIMELESS FANCA DNAJB4 ASNS RECQL CCR1 IL1RAP PLAU IFI16 MCM7 UCP2 RIPK2 MBD4 HSF2 CXCL11 VEGFA PMS2L1 PMS2L2 SUPT16H DERL1 FANCL MUS81 SMC6 SIGIRR FGG MTPN ERRFI1
GO:0006974	BP	response to DNA damage stimulus	0.139534883720930	0.319580636061912	301	9.32733086613409	NONO TOP2A ERCC3 USP1 LIG1 MDC1 FANCG RFC4 RAD51AP1 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B BARD1 CHEK1 BLM POLE2 POLQ PARP1 PRKDC ATR CHEK2 DTL TIPIN DCLRE1B FANCE UHRF1 GEN1 RECQL4 FANCM TYMS RBM14 POLA1 TOPBP1 NCOA6 PMS2L11 RAD21 MSH6 TIMELESS FANCA RECQL IFI16 MCM7 MBD4 PMS2L1 PMS2L2 SUPT16H FANCL MUS81 SMC6
GO:0031224	CC	intrinsic to membrane	0.0299911465250111	0.157595812243598	4518	-4.88204687896592	PIGX NIPA1 LRRC15 HAS3 JPH1 OSMR LAPTM4B CLEC2B TMEM44 MUC4 FAT MCAM PSAP RPN1 GOLGB1 CSE1L MFN2 RAE1 MBTPS1 TMEM106C LPCAT1 SDC4 VAPB MMD SLC7A6 RTN2 SLC25A14 CCR1 TMEFF1 ADAM8 IL1RAP HSD11B1 CD38 GPR176 STX2 OPN1SW NCSTN UCP2 TNFRSF10D KLRC4 SLC43A3 SLC25A17 NIPA2 NUP205 TMEM194 SLC25A44 DPY19L4 KLRB1 FPRL2 TEX10 DERL1 GOLT1B PARL TMEM39A LRRC8D NXT1 C1orf27 SIGIRR SLAMF8 FA2H FKRP SLCO4A1 C20orf30 NUP62CL CHST6 NOMO3 TXNDC11 BRI3 AIFM2 AGPAT6 TMEM173 AADACL1 OMA1 TMEM68 ATP11C QSOX2 TRIM59 ALG10 ACVR1C HS6ST2 CD300LF KIAA1524 SLC16A1 TMEM22 PNLDC1 TMEM49 JTB STOM PTDSS1 INSIG1 CD14 LBR SLC20A1 MEST EFNA1 TMEM184B KPNA1 SLC6A8 PLSCR1 EBP TMPO CD163 CX3CL1 CLCN6 TPST2 C7orf23 MRC1 SLC16A2 PTPRZ1 SELL SLC7A7 AOC3 TLR2 CELSR3 CA9 KIAA0133 LAMP3 SYNGR3 KCNS3 ADAMDEC1 NUP155 GPR19 IL15RA ALG3 TNFSF4 SMPD4 SEMA4F PTPRH RPN2 CXCR4 PPAP2C ATP2C1 FAP B4GALT3 PLAUR ARL6IP1 TMEM97 ATP13A3 NUP210 LHFPL2 PAQR4 ABHD3 SLC38A6 SLC6A10P FAM69A NOMO2 PTPLAD1 TMEM48 TNFRSF12A NUP107 TMEM38B NETO2 CKLF C3orf52 SLC15A3 ALG6 KCNMB3 SOAT1 DOLPP1 FLVCR1 CLPTM1L SLC25A19 NAT14 SLC25A33 ZIC2 TMEM32 CREB3L4 ZDHHC23 RELT C1orf162 ALG10B KRTCAP3 C19orf46 KISS1R
GO:0016796	MF	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.342105263157895	0.472952651463459	19	7.1139190116719	PARN RAD1 EXO1 FEN1 EXOSC9 XRN2 ISG20
GO:0016763	MF	transferase activity, transferring pentosyl groups	0.170454545454545	0.372658298160876	44	4.65108480771803	UMPS PARP2 PARP1 PARP12 PRTFDC1 PARP9 PARP14 HPRT1
GO:0016891	MF	endoribonuclease activity, producing 5'-phosphomonoesters	0.195652173913043	0.391359240769869	23	4.01632416994601	RNASEH2A EXO1 FEN1 RPP25 DBR1
GO:0016895	MF	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.4375	0.495515604482557	8	6.0781173456916	RAD1 EXO1 FEN1 ISG20
GO:0016896	MF	exoribonuclease activity, producing 5'-phosphomonoesters	0.291666666666667	0.45016831868926	12	4.70444361882676	PARN EXOSC9 XRN2 ISG20
GO:0004888	MF	transmembrane receptor activity	0.0169956140350877	0.119395513627964	912	-4.10499023902185	OSMR CCR1 IL1RAP GPR176 OPN1SW TNFRSF10D KLRB1 FPRL2 SIGIRR ACVR1C EBP CD163 PTPRZ1 TLR2 CELSR3 GPR19 IL15RA CXCR4 OLFML2B KISS1R
GO:0007093	BP	mitotic cell cycle checkpoint	0.216666666666667	0.408600077078438	30	5.21275165274994	BUB3 BUB1B BLM KNTC1 CENPF ZWILCH MAD2L1
GO:0007096	BP	regulation of exit from mitosis	0.333333333333333	0.492365963917331	12	5.4874810789733	ANLN BIRC5 UBE2C KNTC1
GO:0009719	BP	response to endogenous stimulus	0.11340206185567	0.294261697228311	388	7.79331181770377	NONO TOP2A ERCC3 USP1 LIG1 HCLS1 MDC1 FANCG RFC4 RAD51AP1 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B BARD1 CHEK1 WNT2 BLM POLE2 POLQ PARP1 PRKDC ATR CHEK2 DTL TIPIN DCLRE1B FANCE UHRF1 GEN1 RECQL4 FANCM TYMS RBM14 POLA1 TOPBP1 NCOA6 PMS2L11 RAD21 MSH6 TIMELESS FANCA RECQL IFI16 MCM7 MBD4 PMS2L1 PMS2L2 SUPT16H FANCL MUS81 SMC6
GO:0007067	BP	mitosis	0.228155339805825	0.399857895667254	206	14.6356388460229	ANLN BIRC5 TARDBP NUSAP1 NUDC BUB3 RUVBL1 CDC25B CDC20 UBE2C SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA NDC80 SMC2 KIF11 NEK2 KIF23 CENPE KNTC1 CENPF KIFC1 SPC25 TPX2 NCAPD3 NCAPH ZWILCH CEP55 FBXO5 TIPIN KIF15 DSN1 NCAPG2 TCF7L1 CDCA8 NUF2 CDCA5 MAD2L1 RAD21 SHC1 SMC4 KIF22 STAG1 TIMELESS DDX11 KIF2C AURKB WEE1 NCAPG TXNL4B CDCA3
GO:0007051	BP	spindle organization and biogenesis	0.447368421052632	0.497067423386217	19	9.60364470128742	UBE2C SPAG5 BUB1B AURKA NDC80 KIF11 KIF23 PRC1 STMN1
GO:0007052	BP	mitotic spindle organization and biogenesis	0.318181818181818	0.462208138868588	11	4.98108862598138	KIF11 KIF23 PRC1 STMN1
GO:0007059	BP	chromosome segregation	0.333333333333333	0.447844807663785	60	12.2888521036363	NUSAP1 TOP2A BUB3 DLG7 NDC80 SMC2 CENPE CENPF KIFC1 NCAPD3 NCAPH DSN1 NCAPG2 STAG3 NUF2 CDCA5 SGOL2 RECQL4 RAD21 SMC4 STAG1 DDX11 NCAPG
GO:0007088	BP	regulation of mitosis	0.1875	0.387091389196070	40	5.0194386752029	ANLN BIRC5 NUSAP1 UBE2C DLG7 NEK2 KNTC1 SHC1
GO:0007089	BP	traversing start control point of mitotic cell cycle	0.4	0.547722557505166	5	4.34991872567081	CDC2 CDC6
GO:0031570	BP	DNA integrity checkpoint	0.293103448275862	0.453503059119276	29	7.3592458041265	CDC6 CDC45L RAD1 CHEK1 BLM ATR CHEK2 TIPIN CDT1
GO:0007076	BP	mitotic chromosome condensation	0.4375	0.478713553878169	16	8.59790801654872	NUSAP1 SMC2 NCAPD3 NCAPH NCAPG2 CDCA5 SMC4 NCAPG
GO:0031577	BP	spindle checkpoint	0.428571428571429	0.534522483824849	7	5.55724577058989	BIRC5 BUB3 CENPF
GO:0007017	BP	microtubule-based process	0.110552763819095	0.302078984888075	199	5.32842401488363	NUSAP1 PSRC1 UBE2C SPAG5 BUB1B AURKA NDC80 KIF11 KIF23 CENPE WNT2 KIF14 KIFC1 PRC1 KIF4A KIF20A KIF15 KIF18A SASS6 CKAP5 CP110 STMN1 KIF22 KIF2C KIF18B
GO:0031519	CC	PcG protein complex	0.357142857142857	0.475594865605671	7	4.53216944154565	EZH2 PCGF6 EED
GO:0007049	BP	cell cycle	0.147346368715084	0.333879418166061	716	15.7395829745511	ANLN CDKN3 BIRC5 TARDBP MPHOSPH9 NUSAP1 NUDC BUB3 MCM3 RUVBL1 CDC25B PSRC1 CKS1B MCM2 ERCC3 CDK4 IRF1 LIG1 CDC20 UBE2C MDC1 SPAG5 CDC2 FANCG BUB1B DLG7 CDC6 AURKA CDC45L NDC80 SMC2 DBF4 PIM2 KIF11 RAD1 CDC7 RAD54L EXO1 NEK2 KIF23 CHAF1B MLF1 CENPE BARD1 CHEK1 BLM KNTC1 CDKN2A CENPF KIFC1 SPC25 ATR TPX2 RBBP4 CHEK2 HSPA2 MKI67 NCAPD3 NCAPH SENP5 DDX12 PRC1 ZWILCH CEP55 SUV39H1 FBXO5 SPHK1 TIPIN KIF15 DSN1 NCAPG2 STAG3 HERC5 BANP E2F8 TCF7L1 CDCA8 NUF2 MND1 CDCA5 UHRF1 CABLES2 C11orf82 SGOL2 SASS6 RECQL4 CKAP2 SUV39H2 MAD2L1 CKAP5 POLA1 CP110 CASP8AP2 RAD21 STMN1 MFN2 SHC1 SMC4 KIF22 STAG1 E2F1 TIMELESS CUL2 E2F3 CDKN2C HHEX INHBA CCNE2 ASNS SYCP2 DDX11 MCM7 KIF2C AURKB CDT1 WEE1 AXIN1 CCNE1 BCAT1 APPL1 APPL2 NCAPG TXNL4B CDCA3 MCM8 E2F7
GO:0031536	BP	positive regulation of exit from mitosis	0.5	0.577350269189626	4	4.97530092767293	BIRC5 UBE2C
GO:0016581	CC	NuRD complex	0.4	0.418330013267038	5	4.34991872567081	RBBP4 APPL1 APPL2
GO:0004523	MF	ribonuclease H activity	0.5	0.547722557505166	6	6.09385548239229	RNASEH2A EXO1 FEN1
GO:0004527	MF	exonuclease activity	0.17	0.358710843699706	50	4.94154853790718	PARN RAD1 EXO1 FEN1 EXOSC9 ISG20L1 XRN2 EXOSC10 ISG20 THEX1
GO:0004529	MF	exodeoxyribonuclease activity	0.4375	0.495515604482557	8	6.0781173456916	RAD1 EXO1 FEN1 ISG20
GO:0004518	MF	nuclease activity	0.105263157894737	0.282391247362453	133	4.01482533207583	RNASEH2A PARN RAD1 EXO1 FEN1 EXOSC9 RPP25 ISG20L1 XRN2 GEN1 FANCM EXOSC10 RNASE1 ISG20 MBD4 MUS81 DBR1 THEX1
GO:0004540	MF	ribonuclease activity	0.160377358490566	0.350461027484078	53	4.70758056356862	RNASEH2A PARN EXO1 FEN1 EXOSC9 RPP25 XRN2 RNASE1 ISG20 DBR1
GO:0004532	MF	exoribonuclease activity	0.291666666666667	0.45016831868926	12	4.70444361882676	PARN EXOSC9 XRN2 ISG20
GO:0016538	MF	cyclin-dependent protein kinase regulator activity	0.416666666666667	0.491596040125088	6	4.98668113491422	CKS1B CABLES2 CCNE2
GO:0000123	CC	histone acetyltransferase complex	0.318181818181818	0.462208138868588	11	4.98108862598138	RUVBL1 ACTL6A C20orf20 TRRAP
GO:0000278	BP	mitotic cell cycle	0.204620462046205	0.378711353472262	303	15.5618419809952	ANLN CDKN3 BIRC5 TARDBP MPHOSPH9 NUSAP1 NUDC BUB3 RUVBL1 CDC25B CDK4 CDC20 UBE2C SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA NDC80 SMC2 DBF4 KIF11 CDC7 NEK2 KIF23 CENPE CHEK1 BLM KNTC1 CDKN2A CENPF KIFC1 SPC25 TPX2 NCAPD3 NCAPH PRC1 ZWILCH CEP55 FBXO5 SPHK1 TIPIN KIF15 DSN1 NCAPG2 TCF7L1 CDCA8 NUF2 CDCA5 MAD2L1 POLA1 RAD21 STMN1 SHC1 SMC4 KIF22 STAG1 E2F1 TIMELESS CUL2 CDKN2C INHBA ASNS DDX11 KIF2C AURKB CDT1 WEE1 CCNE1 BCAT1 NCAPG TXNL4B CDCA3
GO:0000279	BP	M phase	0.210037174721190	0.390574106849445	269	15.1327879638709	ANLN BIRC5 TARDBP MPHOSPH9 NUSAP1 NUDC BUB3 RUVBL1 CDC25B CDC20 UBE2C SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA NDC80 SMC2 PIM2 KIF11 RAD1 RAD54L EXO1 NEK2 KIF23 CENPE CHEK1 KNTC1 CENPF KIFC1 SPC25 TPX2 HSPA2 NCAPD3 NCAPH ZWILCH CEP55 FBXO5 TIPIN KIF15 DSN1 NCAPG2 STAG3 TCF7L1 CDCA8 NUF2 MND1 CDCA5 MAD2L1 RAD21 SHC1 SMC4 KIF22 STAG1 TIMELESS SYCP2 DDX11 KIF2C AURKB WEE1 NCAPG TXNL4B CDCA3
GO:0000226	BP	microtubule cytoskeleton organization and biogenesis	0.157303370786517	0.350288076396816	89	5.94954600297696	NUSAP1 PSRC1 UBE2C SPAG5 BUB1B AURKA NDC80 KIF11 KIF23 WNT2 PRC1 SASS6 CKAP5 CP110 STMN1 KIF2C
GO:0000228	CC	nuclear chromosome	0.161290322580645	0.339126838546761	93	6.29165625216424	CBX3 MCM3 MCM2 SMC2 PRIM1 CHEK1 BLM NCAPD3 SUV39H1 TIPIN STAG3 PIF1 POLA1 TOPBP1 RAD21 TIMELESS SYCP2 MCM7 BAZ1A
GO:0000793	CC	condensed chromosome	0.235849056603774	0.411420774513169	53	7.6921597178805	CBX3 BUB1B SMC2 CENPE CHEK1 BLM CENPF NCAPD3 SUV39H1 DSN1 STAG3 TOPBP1 SMC4 SYCP2
GO:0000794	CC	condensed nuclear chromosome	0.193548387096774	0.380294170234016	31	4.60037321113113	CHEK1 BLM NCAPD3 SUV39H1 STAG3 TOPBP1 SYCP2
GO:0000796	CC	condensin complex	0.625	0.478713553878169	4	6.33122220953293	SMC2 NCAPD3 SMC4
GO:0007346	BP	regulation of mitotic cell cycle	0.225	0.405732231980399	60	7.72959410488522	BIRC5 BUB3 CDC2 BUB1B CDC6 BLM KNTC1 CDKN2A CENPF ZWILCH FBXO5 SPHK1 MAD2L1 ASNS CDT1
GO:0000785	CC	chromatin	0.120915032679739	0.314277281772516	153	5.36381159634879	CBX3 DNMT1 MYBL2 MCM2 TMPO HMGB3 NEFH CENPA CENPF HMGN2 HMG2L1 HMG4L ASF1B SUV39H1 TIPIN TRMT5 SUV39H2 POLA1 TIMELESS CHD1 MCM7
GO:0000775	CC	chromosome, pericentric region	0.304054054054054	0.436498894281952	74	12.2843883496405	BIRC5 CBX3 BUB3 BUB1B NDC80 CENPA CENPE CENPF SPC25 APITD1 ZWILCH SUV39H1 DSN1 CENPN CDCA8 CENPK NUF2 SGOL2 CENPH SUV39H2 MAD2L1 KIF22 KIF2C AURKB CENPQ CENPO
GO:0000776	CC	kinetochore	0.258064516129032	0.425655724381718	31	6.55026567734803	BUB3 BUB1B CENPE CENPF ZWILCH DSN1 CENPH MAD2L1 KIF22
GO:0000777	CC	condensed chromosome kinetochore	0.5	0.534522483824849	8	7.0370184464597	BUB1B CENPE CENPF DSN1
GO:0000779	CC	condensed chromosome, pericentric region	0.555555555555556	0.52704627669473	9	8.36820761075573	CBX3 BUB1B CENPE CENPF DSN1
GO:0044453	CC	nuclear membrane part	0.123655913978495	0.309767742398961	93	4.31771928778661	CBX3 LBR KPNA1 TMPO NUP155 NUP210 TMEM48 NUP107 NARF CSE1L RAE1 NUP205 NXT1 NUP62CL
GO:0044454	CC	nuclear chromosome part	0.1640625	0.345661173442139	64	5.33507073355815	CBX3 MCM3 MCM2 PRIM1 BLM NCAPD3 TIPIN STAG3 PIF1 POLA1 TIMELESS SYCP2 MCM7
GO:0044459	CC	plasma membrane part	0.0238510762070972	0.139686381379517	1719	-4.16131933048586	NEXN HAS3 OSMR CLEC2B MUC4 FAT MCAM PXN SDC4 MMD SLC7A6 SLC25A14 MPDZ CCR1 ADAM8 IL1RAP GPR176 STX2 OPN1SW NCSTN SLC25A17 DMXL2 AXIN1 CYFIP2 TNS4 SHANK3 ACVR1C JTB STOM SLC20A1 EFNA1 SLC6A8 EBP MDC1 CD163 MRC1 SLC16A2 PTPRZ1 SELL SLC7A7 TLR2 WNT2 SYNGR3 KCNS3 MICB GPR19 TNFSF4 SEMA4F CXCR4 SLC6A10P KCNMB3 LDLRAP1 FLVCR1 ZIC2
GO:0031981	CC	nuclear lumen	0.0809294871794872	0.255479472110856	624	5.47144686857816	TAF5 TAF2 AHCTF1 ILF2 RNPS1 SFRS2 HDAC1 TOP2A DKC1 RUVBL1 ERCC3 ACTL6A HCLS1 EZH2 TOE1 FUSIP1 WDHD1 CHAF1B EXOSC9 BLM TAF1A CDKN2A CENPF POLQ PARP1 POLR3C RBBP4 CHEK2 MKI67 POLR2I NOL8 KIF4A C20orf20 NARF E2F8 DDX47 XRN2 GLIS2 NOM1 CCNL1 RBM14 POLA1 EXOSC10 TOPBP1 NCOA6 HNRPK TRRAP E2F1 POLR2D E2F3 ISG20 IFI16 DDX11 MCM7 EED APPL1 APPL2 GMCL1 RCL1 POLR3K CIRH1A E2F7
GO:0031974	CC	membrane-enclosed lumen	0.0694288913773796	0.236034619559759	893	4.68537395129572	TAF5 TAF2 AHCTF1 ILF2 RNPS1 SFRS2 HDAC1 TOP2A DKC1 RUVBL1 ERCC3 ACTL6A HCLS1 EZH2 PDIA5 TOE1 FUSIP1 WDHD1 CHAF1B EXOSC9 BLM TAF1A CDKN2A CENPF POLQ PARP1 HARS2 POLR3C TOR1B DCI RBBP4 CHEK2 MKI67 SUPV3L1 POLR2I NOL8 KIF4A C20orf20 NARF E2F8 DDX47 XRN2 TXNDC12 DNAJB11 GLIS2 NOM1 CCNL1 RBM14 POLA1 COX17 EXOSC10 P4HA1 TOPBP1 NCOA6 HNRPK PPIF MBTPS1 TRRAP E2F1 POLR2D E2F3 ISG20 IFI16 DDX11 PDIA4 MCM7 EED GLUD2 APPL1 APPL2 UGCGL1 GMCL1 RCL1 KTELC1 POLR3K MRPL47 CIRH1A E2F7
GO:0044422	CC	organelle part	0.0641223733003708	0.228187270592908	3236	7.87085529387922	ALG10 ANLN TAF5 TAF2 FILIP1L BIRC5 CBX3 ALMS1 CEP78 MPHOSPH9 AHCTF1 NUSAP1 ILF2 RNPS1 LASP1 SFRS2 NUDC HDAC1 TOP2A DDX23 BUB3 DKC1 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 LBR CDC25B PSRC1 KPNA1 MCM2 ERCC3 PLOD3 PLOD2 ACTL6A EBP CDC20 HCLS1 SPAG5 CDC2 EZH2 TMPO HMGB3 BUB1B DLG7 PDIA5 CDC6 RFC4 TPST2 TOE1 AURKA NDC80 SMC2 FUSIP1 NEFH KIF11 BID NEK2 KIF23 WDHD1 CHAF1B CENPA CENPE PRIM1 EXOSC9 SIP1 BARD1 CHEK1 LAMP3 SNRPG WNT2 BLM GRB14 KNTC1 KIF14 NUP155 TAF1A CDKN2A CENPF ALG3 POLQ SMPD4 PARP1 HMGN2 RPN2 PRKDC HARS2 POLR3C TOR1B KIFC1 DCI SPC25 ATP2C1 TPX2 RPL39L RBBP4 CHEK2 ARL6IP1 MKI67 NUP210 HMG2L1 NCAPD3 SUPV3L1 POLR2I APITD1 HMG4L NOMO2 PRC1 TMEM48 ASF1B NOL8 ZWILCH KIF4A C16orf33 C20orf20 SUV39H1 KIF20A NUP107 TMEM38B CEP192 FBXO5 TIPIN KIF15 C3orf52 DSN1 CENPN SLC15A3 ALG6 STAG3 NARF E2F8 DDX47 KIF18A CDCA8 SOAT1 LDLRAP1 DOLPP1 TRMT5 CENPK XRN2 TXNDC12 DNAJB11 SLC25A19 SLC25A33 GLIS2 NUF2 PCGF6 CDCA5 TMEM32 CREB3L4 NOM1 SGOL2 CENPH SASS6 C19orf46 PIGX C6orf151 JPH1 CKAP2 SUV39H2 MAD2L1 CKAP5 CCNL1 CYP4B1 PIF1 RBM14 POLA1 COX17 EXOSC10 CEP72 P4HA1 TOPBP1 SNRPB2 ARFGAP3 NCOA6 CP110 RPL30 HNRPK RAD21 STMN1 RPN1 GOLGB1 PXN COPB2 CSE1L HAX1 MFN2 DHX15 PPIF RAE1 MBTPS1 SMC4 TMEM106C LPCAT1 KIF22 VAPB TRRAP E2F1 MSH6 TIMELESS MMD OFD1 PCNT POLR2D E2F3 RTN2 CHD1 SLC25A14 ISG20 KRT17 HSD11B1 SNRPA1 IFI16 PEX10 SYCP2 DDX11 PDIA4 MCM7 UCP2 KIF2C AURKB EED CDT1 MAGOH ODF2 GLUD2 SLC25A17 NUP205 SLC25A44 DMN DHODH BAZ1A TEX10 APPL1 DERL1 GOLT1B APPL2 UGCGL1 PARL GMCL1 RCL1 KTELC1 NXT1 TXNL4B POLR3K MYO5C CENPQ FA2H CENPO FKRP CEP97 NUP62CL CHST6 KIF18B MRPL47 AIFM2 CIRH1A E2F7
GO:0044424	CC	intracellular part	0.0502870390814749	0.201666966520825	9058	7.0164757897581	ALG10 ANLN TAF5 POLE4 KIAA1524 CBS TK1 TAF2 FILIP1L SAE1 BIRC5 CBX3 EIF4A2 CAND1 ALMS1 CEP78 TARDBP MPHOSPH9 DMRTA2 PAK2 TMEM22 NOL10 AHCTF1 NUSAP1 PNLDC1 TMEM49 ILF2 NONO RNPS1 LASP1 WARS SFRS2 PSMD2 STAT1 SFRS10 AARS STOM RBBP7 NUDC HDAC1 AKR1B1 TOP2A ENO2 CACYBP IFI30 DDX23 BUB3 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 MTHFD2 ADAR LBR CDC25B GDI1 PSRC1 RAI14 KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 STCH FOXM1 PLOD2 PSMB10 ACTL6A LIG1 EBP PCK2 CDC20 ADM C1QB HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 SPAG5 MTRR CDC2 PAFAH1B3 FAM50A MTF2 EZH2 PSMA4 TMPO SIVA1 FANCG NFIL3 ZNF263 PPRC1 HMGB3 BUB1B DLG7 VRK1 PDIA5 PARN KIAA0649 CDC6 RFC4 TRIP13 TPST2 TOE1 AURKA CDC45L RAD51AP1 NDC80 WASF1 SMC2 DBF4 TEAD4 FUSIP1 NEFH APOC1 KIF11 RAD1 BID CDC7 RAD54L EXO1 NEK2 KIF23 WDHD1 PARP2 FEN1 CHAF1B MLF1 MELK GLDC CENPA CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 CHEK1 ISG15 LAMP3 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 GRB14 NTS KNTC1 KIF14 NUP155 KLHL24 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 IL15RA ALG3 POLQ SMPD4 NVL ECOP ANP32E SEMA4F EPPK1 PRSS16 PTPRH XPNPEP1 PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT CXCR4 NUPR1 HARS2 POLR3C IFI35 TOR1B KIFC1 DCI SPC25 ATR ATP2C1 NCF2 TPX2 RPL39L B4GALT3 RBBP4 CHEK2 HSPA2 ARL6IP1 MKI67 ASXL1 NUP210 HMG2L1 NCAPD3 SUPV3L1 NCAPH POLR2I SENP5 EIF2C2 DDX12 APITD1 TWIST1 GMPS HOXD11 CDC42EP4 HMG4L NOMO2 LAP3 PRC1 TMEM48 ASF1B NIF3L1 NOL8 PFDN2 ZWILCH KIF4A S100PBP CDCA4 C16orf33 PARP12 DUSP12 DTL C20orf20 SUV39H1 ABHD10 SCNM1 KIF20A NUP107 TMEM38B CEP192 FBXO5 ISOC2 RMI1 RPP25 USP18 SPHK1 TIPIN KIF15 DIABLO C3orf52 DCLRE1B DSN1 PALB2 CENPN NCAPG2 SLC15A3 ALG6 STAG3 NARF HERC5 BANP E2F8 FANCE MCM10 DDX47 TCF7L1 KIF18A CDCA8 ANKRD27 SOAT1 ACOT9 DONSON LDLRAP1 DOLPP1 CCDC101 COL8A2 TRMT5 PRTFDC1 CENPK XRN2 TXNDC12 DNAJB11 ADPRHL2 PARP9 SLC25A19 TCF19 NAT14 SLC25A33 GLIS2 NUF2 ZIC2 MND1 PCGF6 C17orf37 C17orf49 PARP14 CDCA5 ZNFX1 CDCA7L TMEM32 CCDC50 C1QC PHF19 UHRF1 CTHRC1 SCYL1BP1 CREB3L4 PRR6 SLFN11 NR2C2AP RELT HPS3 NOM1 RHPN2 C11orf82 GEN1 SGOL2 EID3 CENPH SASS6 ZNF541 C19orf46 ZNF280C PIGX NEXN RECQL4 KLF11 ZNF512 C6orf151 JPH1 ZNF697 TRIM37 CKAP2 FANCM TBK1 SUV39H2 MAD2L1 PLA2G4C AGBL3 PSIP1 CKAP5 ZNF26 CCNL1 CYP4B1 PIF1 RBM14 UCHL1 COTL1 PTHLH HMMR GINS2 POLA1 COX17 EXOSC10 CEP72 PKN3 TXNRD1 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A HPRT1 ARFGAP3 C15orf44 NCOA6 AP3M2 CP110 NEDD4 TACC3 TRAF5 CASP8AP2 ZNF251 NAPB RPL30 HNRPK RAD21 STMN1 PSAP RPN1 GOLGB1 PXN COPB2 CSE1L HAX1 MFN2 ANP32B ETS2 DHX15 SHC1 PPIF NCBP2 RAE1 MBTPS1 SMC4 MCM5 TMEM106C AIP LPCAT1 RRM2 DVL3 FARSA KIF22 CSTF1 STAG1 LPIN2 VAPB GUSB TRRAP TNFAIP3 GPX2 E2F1 CTSS MSH6 PLAGL2 TIMELESS CUL2 DMTF1 ADNP2 MMD RBP1 OFD1 PCNT POLR2D E2F3 MTR FANCA AKR1C1 CDKN2C RTN2 CHD1 PIK3CA TLE2 HIRIP3 SLC25A14 HHEX ISG20 C1orf107 TTF1 CCNE2 RECQL KRT17 HSD11B1 SYT17 PAX6 HSD17B6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PEX10 SYCP2 PTP4A3 FOXN2 ASS1 ZNF225 ZNF45 ZNF200 STX2 CASK DDX11 PDIA4 NCSTN PSMD11 MCM7 UCP2 KIF2C THOC5 AURKB RIPK2 EED MBD4 HSF2 CDT1 CTSZ MAGOH IFT20 ODF2 GLUD2 SLC25A17 CDV3 YARS MCM4 NUP205 SULF1 WEE1 SLC25A44 DMN FTL DMXL2 AXIN1 SMYD2 ZNF473 CCNE1 DHODH MDM1 PMS2L1 BCAT1 FCF1 CYFIP2 TGIF2 ZNF227 NAT13 SNX6 SUPT16H WBP11 USP39 BAZ1A TEX10 APPL1 DERL1 GOLT1B APPL2 UGCGL1 PARL COQ4 FANCL GMCL1 TOR3A MUS81 RCL1 KTELC1 NCAPG NXT1 UTP6 UPF3B SMC6 TXNL4B POLR3K CCDC59 PAPD1 MYO5C DBR1 BXDC2 HSPBAP1 CENPQ FA2H CENPO FKRP CEP97 TRIM45 ATG3 DOK3 NUP62CL ATG16L1 ZNF532 CHST6 CDCA3 CORO1C ETV7 KIF18B TNS4 TRMT6 ZCCHC17 TXNDC11 DTNBP1 MRPL47 MCM8 AIFM2 MTPN ERRFI1 SULF2 AGPAT6 CIRH1A SIN3A MTERFD3 INOC1 ZNF275 EEF2K OMA1 LCOR QSOX2 SHANK3 TOR2A E2F7 IRX2 ZNF367 SIX4
GO:0044425	CC	membrane part	0.0295494441193681	0.156016833340465	5127	-5.55255020755236	PIGX NEXN NIPA1 LRRC15 HAS3 JPH1 OSMR LAPTM4B CYP4B1 CLEC2B TMEM44 MUC4 FAT ARFGAP3 MCAM AP3M2 PSAP RPN1 GOLGB1 PXN COPB2 CSE1L MFN2 RAE1 MBTPS1 TMEM106C LPCAT1 SDC4 VAPB MMD SLC7A6 RTN2 SLC25A14 MPDZ CCR1 TMEFF1 ADAM8 IL1RAP HSD11B1 CD38 GPR176 STX2 OPN1SW NCSTN UCP2 TNFRSF10D KLRC4 SLC43A3 SLC25A17 NIPA2 NUP205 TMEM194 SLC25A44 DMXL2 AXIN1 DPY19L4 KLRB1 FPRL2 CYFIP2 TEX10 DERL1 GOLT1B PARL TMEM39A LRRC8D NXT1 C1orf27 SIGIRR SLAMF8 FA2H FKRP SLCO4A1 C20orf30 NUP62CL CHST6 NOMO3 TNS4 TXNDC11 BRI3 AIFM2 AGPAT6 TMEM173 AADACL1 OMA1 TMEM68 ATP11C QSOX2 TRIM59 SHANK3 ALG10 ACVR1C HS6ST2 CD300LF KIAA1524 CBX3 SLC16A1 MPHOSPH9 TMEM22 PNLDC1 TMEM49 JTB STOM PTDSS1 INSIG1 CD14 LBR SLC20A1 MEST EFNA1 TMEM184B KPNA1 PLOD3 SLC6A8 PLSCR1 PLOD2 EBP MDC1 TMPO CD163 CX3CL1 CLCN6 TPST2 C7orf23 MRC1 SLC16A2 PTPRZ1 SELL SLC7A7 AOC3 TLR2 CELSR3 CA9 KIAA0133 LAMP3 WNT2 SYNGR3 KCNS3 ADAMDEC1 GRB14 MICB NUP155 GPR19 IL15RA ALG3 TNFSF4 SMPD4 SEMA4F PTPRH RPN2 CXCR4 PPAP2C ATP2C1 FAP B4GALT3 PLAUR ARL6IP1 TMEM97 ATP13A3 NUP210 LHFPL2 PAQR4 ABHD3 SLC38A6 SLC6A10P FAM69A NOMO2 PTPLAD1 TMEM48 TNFRSF12A NUP107 TMEM38B NETO2 CKLF C3orf52 SLC15A3 ALG6 NARF KCNMB3 SOAT1 LDLRAP1 DOLPP1 FLVCR1 CLPTM1L SLC25A19 NAT14 SLC25A33 ZIC2 TMEM32 CREB3L4 ZDHHC23 RELT C1orf162 ALG10B KRTCAP3 C19orf46 KISS1R
GO:0044427	CC	chromosomal part	0.168439716312057	0.35668059156008	282	11.6785073596836	BIRC5 CBX3 BUB3 MCM3 DNMT1 MYBL2 MCM2 TMPO HMGB3 BUB1B RFC4 NDC80 SMC2 NEFH CENPA CENPE PRIM1 CHEK1 BLM CENPF HMGN2 SPC25 HMG2L1 NCAPD3 APITD1 HMG4L ASF1B ZWILCH SUV39H1 TIPIN DSN1 CENPN STAG3 CDCA8 TRMT5 CENPK NUF2 CDCA5 SGOL2 CENPH SUV39H2 MAD2L1 PIF1 POLA1 SMC4 KIF22 TIMELESS CHD1 SYCP2 MCM7 KIF2C AURKB CDT1 CENPQ CENPO
GO:0044428	CC	nuclear part	0.0864321608040201	0.261682441850982	995	7.9660631606029	TAF5 TAF2 CBX3 AHCTF1 ILF2 RNPS1 SFRS2 HDAC1 TOP2A DDX23 DKC1 MCM3 RUVBL1 LBR KPNA1 MCM2 ERCC3 ACTL6A HCLS1 EZH2 TMPO BUB1B TOE1 SMC2 FUSIP1 WDHD1 CHAF1B PRIM1 EXOSC9 SIP1 BARD1 CHEK1 SNRPG BLM NUP155 TAF1A CDKN2A CENPF POLQ PARP1 PRKDC POLR3C RBBP4 CHEK2 MKI67 NUP210 NCAPD3 POLR2I TMEM48 NOL8 KIF4A C16orf33 C20orf20 SUV39H1 NUP107 TIPIN STAG3 NARF E2F8 DDX47 XRN2 GLIS2 PCGF6 NOM1 C19orf46 C6orf151 CCNL1 PIF1 RBM14 POLA1 EXOSC10 TOPBP1 SNRPB2 NCOA6 HNRPK RAD21 CSE1L HAX1 DHX15 RAE1 TRRAP E2F1 MSH6 TIMELESS POLR2D E2F3 ISG20 SNRPA1 IFI16 SYCP2 DDX11 MCM7 EED MAGOH NUP205 BAZ1A TEX10 APPL1 APPL2 GMCL1 RCL1 NXT1 TXNL4B POLR3K NUP62CL CIRH1A E2F7
GO:0044446	CC	intracellular organelle part	0.0643211407315561	0.228512794273602	3226	7.9241300240085	ALG10 ANLN TAF5 TAF2 FILIP1L BIRC5 CBX3 ALMS1 CEP78 MPHOSPH9 AHCTF1 NUSAP1 ILF2 RNPS1 LASP1 SFRS2 NUDC HDAC1 TOP2A DDX23 BUB3 DKC1 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 LBR CDC25B PSRC1 KPNA1 MCM2 ERCC3 PLOD3 PLOD2 ACTL6A EBP CDC20 HCLS1 SPAG5 CDC2 EZH2 TMPO HMGB3 BUB1B DLG7 PDIA5 CDC6 RFC4 TPST2 TOE1 AURKA NDC80 SMC2 FUSIP1 NEFH KIF11 BID NEK2 KIF23 WDHD1 CHAF1B CENPA CENPE PRIM1 EXOSC9 SIP1 BARD1 CHEK1 LAMP3 SNRPG WNT2 BLM GRB14 KNTC1 KIF14 NUP155 TAF1A CDKN2A CENPF ALG3 POLQ SMPD4 PARP1 HMGN2 RPN2 PRKDC HARS2 POLR3C TOR1B KIFC1 DCI SPC25 ATP2C1 TPX2 RPL39L RBBP4 CHEK2 ARL6IP1 MKI67 NUP210 HMG2L1 NCAPD3 SUPV3L1 POLR2I APITD1 HMG4L NOMO2 PRC1 TMEM48 ASF1B NOL8 ZWILCH KIF4A C16orf33 C20orf20 SUV39H1 KIF20A NUP107 TMEM38B CEP192 FBXO5 TIPIN KIF15 C3orf52 DSN1 CENPN SLC15A3 ALG6 STAG3 NARF E2F8 DDX47 KIF18A CDCA8 SOAT1 LDLRAP1 DOLPP1 TRMT5 CENPK XRN2 TXNDC12 DNAJB11 SLC25A19 SLC25A33 GLIS2 NUF2 PCGF6 CDCA5 TMEM32 CREB3L4 NOM1 SGOL2 CENPH SASS6 C19orf46 PIGX C6orf151 JPH1 CKAP2 SUV39H2 MAD2L1 CKAP5 CCNL1 CYP4B1 PIF1 RBM14 POLA1 COX17 EXOSC10 CEP72 P4HA1 TOPBP1 SNRPB2 ARFGAP3 NCOA6 CP110 RPL30 HNRPK RAD21 STMN1 RPN1 GOLGB1 PXN COPB2 CSE1L HAX1 MFN2 DHX15 PPIF RAE1 MBTPS1 SMC4 TMEM106C LPCAT1 KIF22 VAPB TRRAP E2F1 MSH6 TIMELESS MMD OFD1 PCNT POLR2D E2F3 RTN2 CHD1 SLC25A14 ISG20 KRT17 HSD11B1 SNRPA1 IFI16 PEX10 SYCP2 DDX11 PDIA4 MCM7 UCP2 KIF2C AURKB EED CDT1 MAGOH ODF2 GLUD2 SLC25A17 NUP205 SLC25A44 DMN DHODH BAZ1A TEX10 APPL1 DERL1 GOLT1B APPL2 UGCGL1 PARL GMCL1 RCL1 KTELC1 NXT1 TXNL4B POLR3K MYO5C CENPQ FA2H CENPO FKRP CEP97 NUP62CL CHST6 KIF18B MRPL47 AIFM2 CIRH1A E2F7
GO:0044430	CC	cytoskeletal part	0.0758564437194127	0.251539947863142	613	4.72647932533277	ANLN FILIP1L BIRC5 CBX3 ALMS1 CEP78 NUSAP1 LASP1 NUDC TOP2A CDC25B PSRC1 CDC20 SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA NEFH KIF11 NEK2 KIF23 CENPE KNTC1 KIF14 CENPF KIFC1 TPX2 PRC1 KIF4A KIF20A CEP192 FBXO5 KIF15 NARF KIF18A SASS6 CKAP2 CKAP5 CEP72 CP110 STMN1 PXN KIF22 OFD1 PCNT KRT17 KIF2C AURKB ODF2 DMN MYO5C CEP97 KIF18B
GO:0000819	BP	sister chromatid segregation	0.416666666666667	0.474947062990896	30	11.1589382036347	NUSAP1 BUB3 DLG7 NDC80 SMC2 CENPE KIFC1 NCAPD3 NCAPH NCAPG2 CDCA5 SMC4 DDX11 NCAPG
GO:0005730	CC	nucleolus	0.104294478527607	0.291091961467598	163	4.3814178859499	TAF5 ILF2 TOP2A DKC1 EXOSC9 BLM TAF1A CDKN2A PARP1 MKI67 NOL8 DDX47 XRN2 NOM1 POLA1 EXOSC10 IFI16 DDX11 RCL1 CIRH1A
GO:0007166	BP	cell surface receptor linked signal transduction	0.0206947524020695	0.128775947958997	1353	-4.30344934035078	OSMR PTHLH PXN SHC1 DVL3 TLE2 HHEX INHBA CCR1 GRP GPR176 OPN1SW NCSTN VEGFA AXIN1 KLRB1 FPRL2 SNX6 SIGIRR EIF4EBP1 CD14 CX3CL1 TLR2 CCL3 CELSR3 NMB WNT2 ADAMDEC1 LY96 GPR19 CXCR4 VEGFC PLAUR NUP85 SPHK1 TCF7L1 RSPO3 KISS1R
GO:0007186	BP	G-protein coupled receptor protein signaling pathway	0.0141043723554302	0.108657422290006	709	-4.02235697553775	PTHLH CCR1 GRP GPR176 OPN1SW FPRL2 CCL3 CELSR3 NMB GPR19 CXCR4 SPHK1 KISS1R
GO:0007126	BP	meiosis	0.144927536231884	0.344082852490013	69	4.67658688730593	PIM2 RAD1 RAD54L EXO1 NEK2 CHEK1 HSPA2 STAG3 MND1 RAD21 SYCP2
GO:0005886	CC	plasma membrane	0.0252412769116555	0.145208907692945	2694	-4.96794429054627	NEXN HAS3 JPH1 OSMR CLEC2B MUC4 CCDC88A FAT MCAM PXN SHC1 SDC4 VAPB GBP2 MMD SLC7A6 SLC25A14 MPDZ CCR1 TMEFF1 ADAM8 IL1RAP CD38 PTP4A3 GPR176 STX2 CASK OPN1SW NCSTN SLC25A17 DMXL2 AXIN1 KLRB1 FPRL2 CYFIP2 TNS4 DTNBP1 SHANK3 ACVR1C CD300LF SLC16A1 GBP1 JTB MARCKSL1 STOM ENO2 CD14 SLC20A1 EFNA1 SLC6A8 PLSCR1 ACTL6A EBP MDC1 CD163 CX3CL1 MRC1 SLC16A2 PTPRZ1 SELL SLC7A7 AOC3 TLR2 CELSR3 CA9 WNT2 SYNGR3 KCNS3 MICB LY96 GPR19 TNFSF4 SEMA4F CXCR4 FAP PLAUR SLC6A10P NUP85 TNFRSF12A KCNMB3 LDLRAP1 FLVCR1 ZIC2 RELT ALG10B GBP5 KISS1R
GO:0003008	BP	system process	0.0163618864292589	0.119091972079477	1039	-4.51462668421404	HPRT1 AKR1C1 PAX6 TDO2 GPR176 OPN1SW FGG DTNBP1 ALMS1 ERCC3 SLC6A8 ADM DFNA5 GCHFR WNT2 IQCB1 NTS SPHK1 KCNMB3 SOAT1 CCDC50
GO:0005876	CC	spindle microtubule	0.388888888888889	0.50163132570455	18	8.00096141910557	BIRC5 SPAG5 CDC2 KIF11 KNTC1 PRC1 KIF4A
GO:0005813	CC	centrosome	0.118320610687023	0.302756954240795	131	4.79807832183333	BIRC5 ALMS1 CEP78 TOP2A CDC25B DLG7 AURKA NEK2 KIFC1 CEP192 KIF15 SASS6 CKAP5 CEP72 CP110 OFD1 PCNT ODF2 CEP97
GO:0005815	CC	microtubule organizing center	0.110714285714286	0.294236343257815	140	4.471350986363	BIRC5 ALMS1 CEP78 TOP2A CDC25B DLG7 AURKA NEK2 KIFC1 CEP192 KIF15 SASS6 CKAP5 CEP72 CP110 OFD1 PCNT ODF2 CEP97
GO:0005819	CC	spindle	0.294520547945205	0.455183238731302	73	11.7579811404592	BIRC5 CBX3 PSRC1 CDC20 SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA KIF11 KIF23 CENPE KNTC1 KIF14 CENPF KIFC1 TPX2 PRC1 KIF4A FBXO5 AURKB
GO:0044237	BP	cellular metabolic process	0.0499058380414313	0.200895358479580	6903	5.12209876275796	ACVR1C ANLN TAF5 CBS TK1 TAF2 SAE1 CDKN3 CBX3 EIF4A2 CAND1 TARDBP DMRTA2 PAK2 AHCTF1 ABCF1 ILF2 NONO RNPS1 WARS SFRS2 STAT1 SFRS10 SEPHS2 AARS RBBP7 HDAC1 TOP2A ENO2 CACYBP PTDSS1 DDX23 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 MTHFD2 ADAR CDC25B PSRC1 SLC20A1 SMS KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 FOXM1 CTPS PLOD2 PSMB10 ACTL6A UMPS LIG1 EBP PCK2 CDC20 ADM C1QB UBE2C HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 MTRR CDC2 EZH2 RPS6KA1 PSMA4 TMPO FANCG AGL NFIL3 ZNF263 PPRC1 HMGB3 BUB1B VRK1 PDIA5 PARN MMP9 CDC6 RFC4 TRIP13 TPST2 AURKA CDC45L RAD51AP1 WASF1 SMC2 DBF4 PIM2 TEAD4 FUSIP1 APOC1 RAD1 PTPRZ1 CDC7 RAD54L MMP12 SLC7A7 EXO1 NEK2 WDHD1 PARP2 NUDT1 FEN1 CHAF1B MLF1 MELK GLDC GCHFR PLK4 AOC3 FST CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 USP13 CHEK1 ISG15 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 ADAMDEC1 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 ALG3 POLQ SMPD4 PRSS16 PTPRH XPNPEP1 PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT CXCR4 HARS2 POLR3C BAG2 APOL1 TOR1B DCI ATR NCF2 FAP INDO RPL39L RBBP4 CHEK2 PLAUR PXDN SR140 ASXL1 HMG2L1 SUPV3L1 POLR2I SENP5 EIF2C2 DDX12 DNA2 TWIST1 GMPS HOXD11 HMG4L PTPLAD1 LAP3 TMEM48 ASF1B NIF3L1 NOL8 PFDN2 C16orf33 DUSP12 DTL C20orf20 SUV39H1 SCNM1 FBXO5 ISOC2 RPP25 USP18 THUMPD2 SPHK1 TIPIN EIF2C3 DCLRE1B NRIP3 PLA1A ALG6 HERC5 MOCOS BANP E2F8 FANCE MCM10 DDX47 TCF7L1 SOAT1 ACOT9 LDLRAP1 DOLPP1 CCDC101 TRMT5 PRTFDC1 XRN2 DNAJB11 UBE2T TCF19 NAT14 GLIS2 MND1 PCGF6 PARP14 ZNFX1 CDCA7L C1QC PHF19 UHRF1 CREB3L4 LYSMD2 NOM1 GEN1 KIAA1804 EID3 ZNF280C PIGX RECQL4 KLF11 ZNF512 C6orf151 ZNF697 FANCM TBK1 ZNF673 SUV39H2 TYMS PLA2G4C AGBL3 PSIP1 ZNF26 CCNL1 PIF1 RBM14 UCHL1 PTHLH GINS2 ZYG11A POLA1 EXOSC10 PKN3 TXNRD1 UPF2 TOPBP1 SNRPB2 CCDC88A HPRT1 NCOA6 NEDD4 CASP8AP2 ZNF251 PMS2L11 RPL30 HNRPK RAD21 STMN1 PSAP DNAJA1 RPN1 PXN CSE1L ETS2 DHX15 SHC1 PPIF NCBP2 MBTPS1 SMC4 MCM5 AIP LPCAT1 RRM2 ARAF FARSA CSTF1 GUSB TRRAP TNFAIP3 E2F1 CTSS MSH6 PLAGL2 TIMELESS CUL2 DMTF1 ADNP2 PRPS2 RBP1 SLC7A6 POLR2D E2F3 MTR FANCA DNAJB4 AKR1C1 CDKN2C CHD1 PIK3CA TLE2 HHEX ISG20 TTF1 INHBA CCNE2 ASNS RECQL ADAM8 FBXO46 HSD11B1 PLAU PAX6 HSD17B6 TDO2 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PTP4A3 FOXN2 ASS1 ZNF225 ZNF45 ZNF200 CASK UCHL5IP OPN1SW DDX11 NCSTN MCM7 AURKB RIPK2 PCYT2 MBD4 HSF2 CDT1 CTSZ MAGOH GLUD2 YARS MCM4 NUP205 SULF1 WEE1 DMXL2 ZNF473 CCNE1 DHODH PMS2L1 BCAT1 PMS2L2 FCF1 TGIF2 ZNF227 NAT13 SNX6 SUPT16H WBP11 USP39 BAZ1A DERL1 UGCGL1 COQ4 FANCL GMCL1 TOR3A MUS81 UTP6 UPF3B SMC6 TXNL4B POLR3K SIGIRR CCDC59 PAPD1 DBR1 FA2H WDR5B FGG FKRP SLCO4A1 ATG3 ZNF532 ADPGK CHST6 CDCA3 EIF4EBP1 ETV7 TRMT6 MRPL47 MCM8 MTPN SULF2 AGPAT6 SIN3A MTERFD3 ZNF275 EEF2K OMA1 KLHL15 THEX1 LCOR ASB2 TOR2A E2F7 ALPK2 IRX2 ZNF367 SIX4 PPIL5
GO:0044238	BP	primary metabolic process	0.0490563319406426	0.198896928897392	6941	4.63676033625683	ACVR1C ANLN TAF5 CBS TK1 TAF2 SAE1 CBX3 EIF4A2 CAND1 TARDBP DMRTA2 PAK2 AHCTF1 ABCF1 ILF2 NONO RNPS1 WARS SFRS2 STAT1 SFRS10 SEPHS2 AARS STOM RBBP7 HDAC1 AKR1B1 TOP2A ENO2 CACYBP PTDSS1 DDX23 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 ADAR CDC25B PSRC1 SMS KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 FOXM1 CTPS PLOD2 PSMB10 ACTL6A UMPS LIG1 EBP PCK2 CDC20 ADM C1QB UBE2C HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 MTRR CDC2 PAFAH1B3 EZH2 RPS6KA1 PSMA4 TMPO FANCG AGL NFIL3 ZNF263 PPRC1 HMGB3 BUB1B VRK1 PDIA5 PARN MMP9 CDC6 RFC4 TRIP13 TPST2 AURKA CDC45L RAD51AP1 WASF1 SMC2 DBF4 PIM2 TEAD4 FUSIP1 APOC1 RAD1 PTPRZ1 CDC7 RAD54L MMP12 SLC7A7 EXO1 NEK2 WDHD1 PARP2 NUDT1 FEN1 CHAF1B MLF1 MELK GLDC PLK4 FST CENPE PRIM1 EXOSC9 SIP1 BARD1 USP13 CHEK1 ISG15 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 ADAMDEC1 PLA2G7 KNTC1 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 ALG3 POLQ SMPD4 PRSS16 PTPRH XPNPEP1 PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT CXCR4 HARS2 POLR3C BAG2 APOL1 TOR1B DCI ATR FAP INDO RPL39L B4GALT3 RBBP4 CHEK2 PLAUR SR140 ASXL1 HMG2L1 SUPV3L1 POLR2I SENP5 EIF2C2 DDX12 DNA2 TWIST1 GMPS HOXD11 HMG4L PTPLAD1 LAP3 TMEM48 ASF1B NIF3L1 NOL8 PFDN2 C16orf33 DUSP12 DTL C20orf20 SUV39H1 SCNM1 FBXO5 ISOC2 RPP25 USP18 SPHK1 TIPIN EIF2C3 DCLRE1B NRIP3 PLA1A ALG6 HERC5 BANP E2F8 FANCE MCM10 DDX47 TCF7L1 SOAT1 ACOT9 LDLRAP1 DOLPP1 CCDC101 TRMT5 PRTFDC1 XRN2 DNAJB11 UBE2T TCF19 NAT14 GLIS2 MND1 PCGF6 PARP14 ZNFX1 CDCA7L C1QC PHF19 UHRF1 CREB3L4 NOM1 GEN1 KIAA1804 EID3 ZNF280C PIGX HAS3 RECQL4 KLF11 ZNF512 C6orf151 ZNF697 FANCM TBK1 ZNF673 SUV39H2 TYMS PLA2G4C AGBL3 PSIP1 ZNF26 CCNL1 PIF1 RBM14 UCHL1 PTHLH GINS2 ZYG11A POLA1 EXOSC10 PKN3 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A HPRT1 NCOA6 AP3M2 NEDD4 CASP8AP2 ZNF251 PMS2L11 RPL30 HNRPK RAD21 STMN1 PSAP DNAJA1 RPN1 PXN COPB2 CSE1L ETS2 DHX15 SHC1 PPIF NCBP2 MBTPS1 SMC4 MCM5 AIP LPCAT1 RRM2 ARAF FARSA CSTF1 GUSB TRRAP TNFAIP3 E2F1 CTSS MSH6 PLAGL2 TIMELESS CUL2 DMTF1 ADNP2 PRPS2 RBP1 SLC7A6 POLR2D E2F3 MTR FANCA DNAJB4 AKR1C1 CHD1 PIK3CA TLE2 HHEX ISG20 TTF1 INHBA CCNE2 ASNS RECQL ADAM8 IL1RAP FBXO46 HSD11B1 PLAU PAX6 HSD17B6 TDO2 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PTP4A3 FOXN2 ASS1 ZNF225 ZNF45 ZNF200 CASK UCHL5IP OPN1SW DDX11 NCSTN MCM7 AURKB RIPK2 PCYT2 MBD4 HSF2 CDT1 CTSZ MAGOH GLUD2 YARS MCM4 NUP205 SULF1 WEE1 DMXL2 ZNF473 CCNE1 DHODH PMS2L1 BCAT1 PMS2L2 FCF1 TGIF2 ZNF227 NAT13 SNX6 SUPT16H WBP11 USP39 BAZ1A DERL1 UGCGL1 FANCL GMCL1 TOR3A MUS81 UTP6 UPF3B SMC6 TXNL4B POLR3K SIGIRR CCDC59 PAPD1 DBR1 FA2H WDR5B FGG FKRP SLCO4A1 ATG3 ZNF532 ADPGK CHST6 CDCA3 EIF4EBP1 ETV7 TRMT6 MRPL47 MCM8 MTPN SULF2 AGPAT6 SIN3A MTERFD3 ZNF275 EEF2K OMA1 KLHL15 THEX1 LCOR ASB2 TOR2A E2F7 ALPK2 IRX2 ZNF367 SIX4 PPIL5
GO:0005521	MF	lamin binding	0.6	0.547722557505166	5	6.77554031587209	LBR TMPO NARF
GO:0005524	MF	ATP binding	0.0694227769110764	0.239243820533524	1282	5.68638347464293	ACVR1C TK1 EIF4A2 PAK2 ABCF1 ILF2 WARS SEPHS2 AARS TOP2A DDX23 MCM3 RUVBL1 MCM2 ERCC3 CDK4 ABCF3 STCH ACTL6A LIG1 HLTF CDC2 RPS6KA1 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L NEK2 KIF23 MELK PLK4 CENPE CHEK1 BLM KIF14 POLQ NVL PRKDC HARS2 TOR1B KIFC1 ATP2C1 TPX2 CHEK2 HSPA2 MKI67 ATP13A3 SUPV3L1 DDX12 DNA2 GMPS KIF4A KIF20A ATAD2 SPHK1 KIF15 DDX47 KIF18A ZNFX1 CHTF18 SLFN11 KIAA1804 NLRP7 RECQL4 SLFN13 FANCM TBK1 PIF1 PKN3 PMS2L11 DHX15 SMC4 MCM5 ARAF FARSA KIF22 MSH6 CHD1 RECQL ASS1 CASK DDX11 MCM7 KIF2C AURKB RIPK2 YARS MCM4 WEE1 PMS2L1 PMS2L2 TOR3A SMC6 MYO5C KIF18B MCM8 INOC1 EEF2K ATP11C TOR2A ALPK2
GO:0005694	CC	chromosome	0.153846153846154	0.340186717799739	338	11.3378365529671	BIRC5 CBX3 TOP2A BUB3 MCM3 DNMT1 MYBL2 MCM2 TMPO HMGB3 BUB1B RFC4 NDC80 SMC2 NEFH CENPA CENPE PRIM1 CHEK1 BLM CENPF HMGN2 SPC25 ATR HMG2L1 NCAPD3 APITD1 HMG4L ASF1B ZWILCH SUV39H1 TIPIN DSN1 CENPN STAG3 CDCA8 TRMT5 CENPK NUF2 CDCA5 SGOL2 CENPH SUV39H2 MAD2L1 PIF1 POLA1 TOPBP1 RAD21 SMC4 KIF22 TIMELESS CHD1 SYCP2 MCM7 KIF2C AURKB CDT1 SUPT16H BAZ1A SMC6 CENPQ CENPO
GO:0005654	CC	nucleoplasm	0.0779220779220779	0.249488870964088	462	4.3275889713571	TAF5 TAF2 RNPS1 SFRS2 HDAC1 TOP2A DKC1 RUVBL1 ERCC3 ACTL6A HCLS1 EZH2 TOE1 FUSIP1 WDHD1 CHAF1B BLM TAF1A CDKN2A POLQ POLR3C RBBP4 CHEK2 POLR2I C20orf20 E2F8 GLIS2 CCNL1 RBM14 POLA1 TOPBP1 NCOA6 HNRPK TRRAP E2F1 POLR2D E2F3 ISG20 IFI16 MCM7 EED APPL1 APPL2 POLR3K E2F7
GO:0017056	MF	structural constituent of nuclear pore	0.5	0.5	5	5.56272952077145	NUP155 TMEM48 NUP62CL
GO:0005657	CC	replication fork	0.25	0.410004205192901	30	6.20378274456407	MCM3 DNMT1 RFC4 PRIM1 CHEK1 BLM POLA1 MCM7 CDT1
GO:0005658	CC	alpha DNA polymerase:primase complex	0.416666666666667	0.491596040125088	6	4.98668113491422	MCM3 PRIM1 POLA1
GO:0005689	CC	U12-dependent spliceosome	0.272727272727273	0.410099766132362	11	4.16325826284089	DDX23 C16orf33 C6orf151 DHX15
GO:0005622	CC	intracellular	0.0494992092778071	0.199907750035507	9485	6.75948723947167	ALG10 ANLN TAF5 POLE4 KIAA1524 CBS TK1 TAF2 FILIP1L SAE1 BIRC5 CBX3 EIF4A2 CAND1 ALMS1 CEP78 TARDBP MPHOSPH9 ARHGAP11B DMRTA2 PAK2 TMEM22 NOL10 AHCTF1 NUSAP1 PNLDC1 TMEM49 ILF2 NONO RNPS1 LASP1 WARS SFRS2 PSMD2 ZNF313 STAT1 SFRS10 AARS STOM RBBP7 NUDC HDAC1 AKR1B1 TOP2A ENO2 CACYBP IFI30 DDX23 BUB3 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 MTHFD2 ADAR LBR CDC25B GDI1 PSRC1 RAI14 KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 STCH FOXM1 PLOD2 PSMB10 ACTL6A LIG1 EBP PCK2 CDC20 ADM C1QB HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 SPAG5 MTRR CDC2 PAFAH1B3 FAM50A MTF2 EZH2 PSMA4 TMPO SIVA1 FANCG NFIL3 ZNF263 PPRC1 HMGB3 BUB1B DLG7 VRK1 PDIA5 PARN KIAA0649 CDC6 RFC4 TRIP13 TPST2 TOE1 AURKA CDC45L RAD51AP1 NDC80 WASF1 SMC2 DBF4 TEAD4 FUSIP1 NEFH APOC1 KIF11 RAD1 BID CDC7 RAD54L EXO1 NEK2 KIF23 WDHD1 PARP2 FEN1 CHAF1B MLF1 MELK GLDC CENPA CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 CHEK1 ISG15 LAMP3 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 GRB14 NTS KNTC1 KIF14 NUP155 KLHL24 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 IL15RA ALG3 POLQ SMPD4 NVL ECOP ANP32E SEMA4F EPPK1 PRSS16 PTPRH XPNPEP1 PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT CXCR4 NUPR1 HARS2 POLR3C IFI35 TOR1B KIFC1 DCI SPC25 ATR ATP2C1 NCF2 TPX2 RPL39L B4GALT3 RBBP4 CHEK2 HSPA2 ARL6IP1 MKI67 ASXL1 NUP210 HMG2L1 NCAPD3 SUPV3L1 NCAPH POLR2I SENP5 EIF2C2 DDX12 APITD1 TWIST1 GMPS HOXD11 CDC42EP4 HMG4L NOMO2 LAP3 PRC1 TMEM48 ASF1B NIF3L1 NOL8 TBC1D15 PFDN2 ZWILCH KIF4A S100PBP CDCA4 C16orf33 PARP12 DUSP12 DTL C20orf20 SUV39H1 ABHD10 SCNM1 KIF20A NUP107 TMEM38B CEP192 FBXO5 ISOC2 RMI1 RPP25 USP18 SPHK1 TIPIN KIF15 DIABLO ISG20L1 C3orf52 DCLRE1B DSN1 PALB2 CENPN NCAPG2 SLC15A3 ALG6 STAG3 GPATCH1 NARF HERC5 BANP E2F8 FANCE DEPDC1 MCM10 DDX47 TCF7L1 KIF18A CDCA8 ANKRD27 SOAT1 ACOT9 DONSON LDLRAP1 DOLPP1 CCDC101 COL8A2 TRMT5 PRTFDC1 CENPK XRN2 TXNDC12 DNAJB11 ADPRHL2 PARP9 SLC25A19 TCF19 NAT14 SLC25A33 GLIS2 NUF2 ZIC2 MND1 PCGF6 C17orf37 C17orf49 PARP14 CDCA5 ZNFX1 CDCA7L TMEM32 CCDC50 C1QC PHF19 UHRF1 CTHRC1 ZNF828 SCYL1BP1 CREB3L4 PRR6 SLFN11 NR2C2AP RELT HPS3 NOM1 RHPN2 PLEKHG4 C11orf82 GEN1 SGOL2 EID3 CENPH SASS6 ZNF541 C19orf46 ZNF280C PIGX NEXN RECQL4 KLF11 ZNF512 C6orf151 SLFN13 JPH1 ZNF697 TRIM37 TRIM74 CKAP2 FANCM TBK1 ZNF673 SUV39H2 MAD2L1 PLA2G4C AGBL3 PSIP1 CKAP5 ZNF26 CCNL1 CYP4B1 PIF1 RBM14 UCHL1 COTL1 WDR67 PTHLH HMMR GINS2 POLA1 COX17 EXOSC10 CEP72 SYDE2 PKN3 TXNRD1 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A HPRT1 ARFGAP3 TRIM52 C15orf44 NCOA6 AP3M2 CP110 NEDD4 TACC3 TRAF5 CASP8AP2 ZNF251 NAPB RPL30 HNRPK RAD21 STMN1 PSAP RPN1 GOLGB1 PXN COPB2 CSE1L HAX1 MFN2 ANP32B ETS2 DHX15 SHC1 PPIF NCBP2 RAE1 MBTPS1 SMC4 MCM5 TMEM106C AIP LPCAT1 RRM2 DVL3 FARSA KIF22 CSTF1 STAG1 LPIN2 VAPB GUSB TRRAP TNFAIP3 GPX2 E2F1 CTSS MSH6 PLAGL2 TIMELESS CUL2 DMTF1 ADNP2 MMD RBP1 OFD1 PCNT POLR2D E2F3 MTR FANCA AKR1C1 CDKN2C RTN2 CHD1 PIK3CA TLE2 HIRIP3 SLC25A14 HHEX ISG20 C1orf107 TTF1 CCNE2 RECQL KRT17 HSD11B1 SYT17 PAX6 HSD17B6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PEX10 SYCP2 PTP4A3 FOXN2 ASS1 ZNF225 ZNF45 ZNF200 STX2 CASK UCHL5IP DDX11 PDIA4 NCSTN PSMD11 MCM7 UCP2 KIF2C THOC5 AURKB RIPK2 EED MBD4 HSF2 CDT1 TRIM9 CTSZ MAGOH IFT20 ODF2 GLUD2 SLC25A17 CDV3 YARS MCM4 NUP205 SULF1 WEE1 SLC25A44 DMN FTL DMXL2 AXIN1 SMYD2 ZNF473 CCNE1 DHODH MDM1 PMS2L1 BCAT1 FCF1 CYFIP2 TGIF2 ZNF227 NAT13 SNX6 SUPT16H WBP11 USP39 BAZ1A TEX10 APPL1 DERL1 GOLT1B APPL2 UGCGL1 PARL COQ4 FANCL GMCL1 TOR3A MUS81 RCL1 KTELC1 NCAPG NXT1 UTP6 UPF3B SMC6 TXNL4B POLR3K CCDC59 PAPD1 MYO5C DBR1 BXDC2 HSPBAP1 CENPQ FA2H CENPO FKRP CEP97 TRIM45 ATG3 DOK3 FLJ21865 NUP62CL ATG16L1 ZNF532 CHST6 CDCA3 CORO1C ETV7 KIF18B TNS4 TRMT6 ZCCHC17 TXNDC11 DTNBP1 MRPL47 MCM8 AIFM2 MTPN ERRFI1 SULF2 AGPAT6 CIRH1A TBC1D23 SIN3A MTERFD3 INOC1 ZNF275 EEF2K OMA1 THEX1 LCOR QSOX2 TRIM59 SHANK3 TOR2A E2F7 IRX2 ZNF367 SIX4
GO:0005634	CC	nucleus	0.066977829638273	0.233352021507422	4285	10.6390372859392	ANLN TAF5 POLE4 CBS TAF2 SAE1 BIRC5 CBX3 CAND1 TARDBP DMRTA2 PAK2 NOL10 AHCTF1 NUSAP1 PNLDC1 ILF2 NONO RNPS1 SFRS2 STAT1 SFRS10 RBBP7 NUDC HDAC1 TOP2A CACYBP DDX23 BUB3 DKC1 ELF3 MCM3 RUVBL1 DNMT1 MYBL2 ADAR LBR KPNA1 MCM2 ERCC3 CDK4 USP1 IRF1 FOXM1 PSMB10 ACTL6A LIG1 HCLS1 HLTF RNASEH2A MDC1 HAT1 CDC2 FAM50A MTF2 EZH2 PSMA4 TMPO SIVA1 FANCG NFIL3 ZNF263 PPRC1 HMGB3 BUB1B DLG7 VRK1 PARN KIAA0649 CDC6 RFC4 TRIP13 TOE1 AURKA CDC45L RAD51AP1 NDC80 SMC2 DBF4 TEAD4 FUSIP1 NEFH RAD1 CDC7 RAD54L EXO1 NEK2 KIF23 WDHD1 PARP2 FEN1 CHAF1B MLF1 CENPA CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 CHEK1 SNRPG BLM POLE2 GINS1 KNTC1 KIF14 NUP155 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 IL15RA POLQ NVL ANP32E PTTG3 PARP1 HMGN2 PRKDC PSMA6 DUT NUPR1 POLR3C IFI35 KIFC1 SPC25 ATR TPX2 RBBP4 CHEK2 MKI67 ASXL1 NUP210 HMG2L1 NCAPD3 SUPV3L1 NCAPH POLR2I SENP5 DDX12 APITD1 TWIST1 HOXD11 HMG4L PRC1 TMEM48 ASF1B NOL8 KIF4A S100PBP CDCA4 C16orf33 PARP12 DUSP12 DTL C20orf20 SUV39H1 SCNM1 NUP107 FBXO5 ISOC2 RMI1 RPP25 USP18 TIPIN DCLRE1B DSN1 PALB2 CENPN NCAPG2 STAG3 NARF BANP E2F8 FANCE MCM10 DDX47 TCF7L1 KIF18A CDCA8 DONSON CCDC101 TRMT5 CENPK XRN2 DNAJB11 ADPRHL2 PARP9 TCF19 NAT14 GLIS2 NUF2 ZIC2 MND1 PCGF6 C17orf49 PARP14 CDCA5 ZNFX1 CDCA7L PHF19 UHRF1 CREB3L4 PRR6 SLFN11 NR2C2AP NOM1 C11orf82 GEN1 SGOL2 EID3 CENPH ZNF541 C19orf46 ZNF280C RECQL4 KLF11 ZNF512 C6orf151 ZNF697 FANCM SUV39H2 MAD2L1 PSIP1 ZNF26 CCNL1 PIF1 RBM14 PTHLH GINS2 POLA1 EXOSC10 PKN3 TXNRD1 UPF2 TOPBP1 SNRPB2 NCOA6 CASP8AP2 ZNF251 HNRPK RAD21 CSE1L HAX1 ANP32B ETS2 DHX15 NCBP2 RAE1 SMC4 MCM5 KIF22 CSTF1 STAG1 LPIN2 TRRAP TNFAIP3 E2F1 MSH6 PLAGL2 TIMELESS DMTF1 ADNP2 POLR2D E2F3 FANCA CDKN2C CHD1 TLE2 HIRIP3 HHEX ISG20 C1orf107 TTF1 CCNE2 RECQL PAX6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 SYCP2 FOXN2 ZNF225 ZNF45 ZNF200 CASK DDX11 MCM7 KIF2C THOC5 AURKB EED MBD4 HSF2 CDT1 MAGOH MCM4 NUP205 WEE1 AXIN1 SMYD2 ZNF473 CCNE1 MDM1 PMS2L1 FCF1 TGIF2 ZNF227 SUPT16H WBP11 USP39 BAZ1A TEX10 APPL1 APPL2 PARL FANCL GMCL1 MUS81 RCL1 NCAPG NXT1 UTP6 UPF3B SMC6 TXNL4B POLR3K CCDC59 DBR1 BXDC2 CENPQ CENPO TRIM45 NUP62CL ZNF532 ETV7 TRMT6 ZCCHC17 DTNBP1 MCM8 CIRH1A SIN3A INOC1 ZNF275 LCOR QSOX2 E2F7 IRX2 ZNF367 SIX4
GO:0005637	CC	nuclear inner membrane	0.222222222222222	0.427792631946499	18	4.16415655141645	CBX3 LBR TMPO NARF
GO:0010458	BP	exit from mitosis	0.307692307692308	0.480384461415261	13	5.21016905530523	ANLN BIRC5 UBE2C KNTC1
GO:0050000	BP	chromosome localization	0.833333333333333	0.408248290463863	6	10.5225528723046	BIRC5 DLG7 CENPE CENPF CDCA5
GO:0000922	CC	spindle pole	0.227272727272727	0.428932027228889	22	4.73277871696172	DLG7 KIF11 KNTC1 CENPF TPX2
GO:0032392	BP	DNA geometric change	0.25	0.427425207132555	14	4.23586784589037	MCM2 ERCC3 SUPV3L1 MCM4
GO:0003777	MF	microtubule motor activity	0.13125	0.325535099898341	80	4.37222729543548	KIF11 KIF23 CENPE KIF14 KIFC1 KIF4A KIF20A KIF15 KIF18A KIF22 KIF2C KIF18B
GO:0032297	BP	negative regulation of DNA replication initiation	0.583333333333333	0.491596040125088	6	7.20102982987036	CDC6 CDC45L TIPIN CDT1
GO:0045787	BP	positive regulation of cell cycle	0.192307692307692	0.376215977250384	26	4.17807668805331	BIRC5 NUSAP1 DLG7 SPHK1 SHC1 ASNS
GO:0003847	MF	1-alkyl-2-acetylglycerophosphocholine esterase activity	0.4	0.547722557505166	5	4.34991872567081	PAFAH1B3 PLA2G7
GO:0051052	BP	regulation of DNA metabolic process	0.140350877192982	0.323959680649794	57	4.06120134378698	KPNA1 CDC6 CDC45L BLM ATR TIPIN PIF1 CCDC88A TTF1 CDT1
GO:0051053	BP	negative regulation of DNA metabolic process	0.272727272727273	0.428932027228889	22	5.88976378816982	CDC6 CDC45L BLM ATR TIPIN TTF1 CDT1
GO:0003682	MF	chromatin binding	0.127777777777778	0.314098595333554	90	4.45976455221409	CBX3 TOP2A ACTL6A CDC6 CHAF1B CENPA CENPF SUV39H1 CDCA5 SUV39H2 POLA1 NCOA6 CHD1 TTF1
GO:0003676	MF	nucleic acid binding	0.0548397753551371	0.210746162261178	3027	4.47484355276871	TAF5 POLE4 EIF4A2 TARDBP DMRTA2 AHCTF1 NUSAP1 PNLDC1 ABCF1 ILF2 NONO RNPS1 SFRS2 STAT1 SFRS10 AARS HDAC1 TOP2A DDX23 DKC1 ELF3 MCM3 DNMT1 MYBL2 ADAR LBR MCM2 ERCC3 IRF1 FOXM1 LIG1 HCLS1 HLTF RNASEH2A MTF2 EZH2 TMPO FANCG NFIL3 ZNF263 PPRC1 HMGB3 PARN RFC4 TOE1 RAD51AP1 DBF4 TEAD4 FUSIP1 NEFH RAD1 RAD54L EXO1 WDHD1 PARP2 FEN1 MLF1 CENPA EXOSC9 SIP1 BARD1 SNRPG BLM POLE2 TAF1A APOBEC3B ZNF165 HOXC6 CDKN2A HOXD10 POLQ PARP1 HMGN2 PRKDC PSMA6 POLR3C ATR SR140 HMG2L1 SUPV3L1 POLR2I EIF2C2 DDX12 APITD1 DNA2 TWIST1 HOXD11 HMG4L NOL8 KIF4A PARP12 DUSP12 RMI1 RPP25 THUMPD2 SPHK1 KIF15 ISG20L1 EIF2C3 GPATCH1 BANP E2F8 DDX47 TCF7L1 TRMT5 XRN2 TCF19 NAT14 GLIS2 ZIC2 MND1 PCGF6 C17orf49 ZNFX1 PHF19 UHRF1 ZNF828 CREB3L4 GEN1 ZNF541 ZNF280C RECQL4 KLF11 ZNF512 ZNF697 FANCM ZNF673 PSIP1 ZNF26 PIF1 RBM14 POLA1 EXOSC10 UPF2 TOPBP1 SNRPB2 C16orf75 ZNF251 PMS2L11 RPL30 HNRPK RPN1 ETS2 DHX15 NCBP2 RAE1 MCM5 RNASE1 KIF22 CSTF1 TNFAIP3 E2F1 MSH6 PLAGL2 DMTF1 ADNP2 E2F3 RBMX2 CHD1 HHEX ISG20 TTF1 RECQL PAX6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 SYCP2 FOXN2 ZNF225 ZNF45 ZNF200 DDX11 MCM7 KIF2C MBD4 HSF2 CDT1 MAGOH YARS MCM4 DMXL2 ZNF473 PMS2L1 PMS2L2 TGIF2 ZNF227 WBP11 MUS81 UPF3B POLR3K PAPD1 ZNF532 ETV7 TRMT6 ZCCHC17 MCM8 AIFM2 TTC14 INOC1 ZNF275 EEF2K THEX1 LCOR E2F7 IRX2 ZNF367 SIX4
GO:0003678	MF	DNA helicase activity	0.229729729729730	0.365045556414892	37	6.22172829757271	RUVBL1 ERCC3 BLM SUPV3L1 DDX12 RECQL4 PIF1 CHD1 RECQL DDX11 MCM4 INOC1
GO:0015630	CC	microtubule cytoskeleton	0.106382978723404	0.293233380778582	376	6.92196937878905	BIRC5 CBX3 ALMS1 CEP78 NUSAP1 NUDC TOP2A CDC25B PSRC1 CDC20 SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA KIF11 NEK2 KIF23 CENPE KNTC1 KIF14 CENPF KIFC1 TPX2 PRC1 KIF4A KIF20A CEP192 FBXO5 KIF15 KIF18A SASS6 CKAP2 CKAP5 CEP72 CP110 STMN1 PXN KIF22 OFD1 PCNT KIF2C AURKB ODF2 CEP97 KIF18B
GO:0008094	MF	DNA-dependent ATPase activity	0.235294117647059	0.378852757367168	51	7.523629540471	TOP2A MCM3 MCM2 ERCC3 RFC4 BLM RBBP4 DDX12 PIF1 MCM5 CHD1 RECQL DDX11 MCM7 MCM4 MCM8
GO:0032559	MF	adenyl ribonucleotide binding	0.0684615384615385	0.237719021940926	1300	5.53358138481131	ACVR1C TK1 EIF4A2 PAK2 ABCF1 ILF2 WARS SEPHS2 AARS TOP2A DDX23 MCM3 RUVBL1 MCM2 ERCC3 CDK4 ABCF3 STCH ACTL6A LIG1 HLTF CDC2 RPS6KA1 BUB1B VRK1 CDC6 RFC4 TRIP13 AURKA SMC2 PIM2 KIF11 CDC7 RAD54L NEK2 KIF23 MELK PLK4 CENPE CHEK1 BLM KIF14 POLQ NVL PRKDC HARS2 TOR1B KIFC1 ATP2C1 TPX2 CHEK2 HSPA2 MKI67 ATP13A3 SUPV3L1 DDX12 DNA2 GMPS KIF4A KIF20A ATAD2 SPHK1 KIF15 DDX47 KIF18A ZNFX1 CHTF18 SLFN11 KIAA1804 NLRP7 RECQL4 SLFN13 FANCM TBK1 PIF1 PKN3 PMS2L11 DHX15 SMC4 MCM5 ARAF FARSA KIF22 MSH6 CHD1 RECQL ASS1 CASK DDX11 MCM7 KIF2C AURKB RIPK2 YARS MCM4 WEE1 PMS2L1 PMS2L2 TOR3A SMC6 MYO5C KIF18B MCM8 INOC1 EEF2K ATP11C TOR2A ALPK2
GO:0050877	BP	neurological system process	0.0153846153846154	0.115073145323151	780	-4.02997866990679	HPRT1 PAX6 TDO2 GPR176 OPN1SW DTNBP1 ALMS1 ERCC3 SLC6A8 DFNA5 GCHFR WNT2 IQCB1 KCNMB3 CCDC50
GO:0032501	BP	multicellular organismal process	0.0269181173436493	0.150782477212418	3102	-4.85046346783438	RECQL4 JPH1 PTHLH HPRT1 SPP1 NCOA6 STMN1 ETS2 DVL3 TNFAIP2 E2F1 TIMELESS MTR AKR1C1 CDKN2C TLE2 HHEX C1orf107 INHBA TMEFF1 KRT17 HSD11B1 PLAU PAX6 TDO2 LHX2 IFI16 GPR176 ZNF45 STX2 OPN1SW ODF2 VEGFA AXIN1 GMCL1 SIGIRR FGG ETV7 DTNBP1 MTPN AGPAT6 SHANK3 SIX4 ALMS1 AHCTF1 ZNF313 RBBP7 NUDC ELF3 MYBL2 MEST ERCC3 SLC6A8 PLSCR1 IRF1 LIG1 EBP ADM C1QB HCLS1 PAFAH1B3 DFNA5 HMGB3 MMP9 TEAD4 NEFH PTPRZ1 MLF1 GCHFR TLR2 FST CELSR3 BARD1 WNT2 COMP BLM IQCB1 GINS1 NTS HOXC6 CENPF HOXD10 SEMA4F MDK CXCR4 ATR ATP2C1 VEGFC PLAUR TWIST1 HOXD11 ASF1B TNFRSF12A GREM1 SPHK1 BANP TCF7L1 KCNMB3 SOAT1 DONSON FLVCR1 GLIS2 ZIC2 CCDC50 C1QC
GO:0032508	BP	DNA duplex unwinding	0.25	0.427425207132555	14	4.23586784589037	MCM2 ERCC3 SUPV3L1 MCM4
GO:0006323	BP	DNA packaging	0.136792452830189	0.334756619963167	106	5.34741268878987	NUSAP1 TOP2A MCM2 HAT1 SMC2 NEFH CHAF1B CENPA NCAPD3 NCAPH ASF1B NCAPG2 CDCA5 SMC4 NCAPG AIFM2
GO:0006310	BP	DNA recombination	0.151041666666667	0.33340185699185	96	5.84673421310619	NONO RUVBL1 KPNA1 LIG1 RAD51AP1 RAD54L EXO1 CHEK1 BLM PRKDC MND1 RECQL4 RBM14 NCOA6 RAD21 RECQL MUS81 SMC6
GO:0006302	BP	double-strand break repair	0.171428571428571	0.36264666693907	35	4.17833534404165	RAD51AP1 RAD54L FEN1 BLM PRKDC POLA1 RAD21
GO:0051383	BP	kinetochore organization and biogenesis	0.75	0.5	4	7.68714349139294	CENPE CENPF CENPH
GO:0051321	BP	meiotic cell cycle	0.140845070422535	0.339990531291989	71	4.55721326787278	PIM2 RAD1 RAD54L EXO1 NEK2 CHEK1 HSPA2 STAG3 MND1 RAD21 SYCP2
GO:0051325	BP	interphase	0.204545454545455	0.368566371667206	88	8.32579546533847	CDKN3 BIRC5 CDK4 CDC2 CDC6 DBF4 CDC7 CHEK1 BLM CDKN2A CENPF TIPIN CDCA5 POLA1 E2F1 TIMELESS CUL2 CDKN2C INHBA DDX11 CDT1 CCNE1 BCAT1
GO:0051327	BP	M phase of meiotic cell cycle	0.144927536231884	0.344082852490013	69	4.67658688730593	PIM2 RAD1 RAD54L EXO1 NEK2 CHEK1 HSPA2 STAG3 MND1 RAD21 SYCP2
GO:0051329	BP	interphase of mitotic cell cycle	0.198795180722892	0.365758142100865	83	7.79969974089783	CDKN3 BIRC5 CDK4 CDC2 CDC6 DBF4 CDC7 CHEK1 BLM CDKN2A CENPF CDCA5 POLA1 E2F1 CUL2 CDKN2C INHBA DDX11 CDT1 CCNE1 BCAT1
GO:0051310	BP	metaphase plate congression	0.75	0.5	4	7.68714349139294	CENPE CENPF CDCA5
GO:0051319	BP	G2 phase	0.4	0.547722557505166	5	4.34991872567081	BLM CENPF
GO:0051301	BP	cell division	0.216517857142857	0.394746236977560	224	14.3191478685983	ANLN BIRC5 NUSAP1 NUDC RUVBL1 CDC25B CKS1B CDK4 LIG1 CDC20 UBE2C SPAG5 CDC2 BUB1B CDC6 NDC80 SMC2 KIF11 CDC7 NEK2 KIF23 CENPE BLM KNTC1 CENPF KIFC1 SPC25 NCAPD3 NCAPH SENP5 PRC1 ZWILCH CEP55 FBXO5 TIPIN DSN1 NCAPG2 CDCA8 NUF2 CDCA5 CABLES2 SGOL2 MAD2L1 RAD21 SMC4 STAG1 TIMELESS CCNE2 SYCP2 STX2 AURKB WEE1 CCNE1 NCAPG CDCA3
GO:0051303	BP	establishment of chromosome localization	0.833333333333333	0.408248290463863	6	10.5225528723046	BIRC5 DLG7 CENPE CENPF CDCA5
GO:0003950	MF	NAD+ ADP-ribosyltransferase activity	0.217391304347826	0.42174116783665	23	4.58211874679277	PARP2 PARP1 PARP12 PARP9 PARP14
GO:0030496	CC	midbody	0.4	0.459468291736341	10	6.15267632991309	BIRC5 PSRC1 CDC2 STX2 AURKB
GO:0043189	CC	H4/H2A histone acetyltransferase complex	0.5	0.5	7	6.58232209963413	RUVBL1 ACTL6A C20orf20 TRRAP
GO:0043170	BP	macromolecule metabolic process	0.0505856391105076	0.201827591852004	5891	4.84449199973255	ACVR1C ANLN TAF5 TK1 TAF2 SAE1 CBX3 EIF4A2 CAND1 TARDBP DMRTA2 PAK2 ABCF1 ILF2 NONO RNPS1 WARS SFRS2 STAT1 SFRS10 AARS STOM RBBP7 HDAC1 TOP2A ENO2 CACYBP DDX23 DKC1 ELF3 MCM3 RUVBL1 DNMT1 MYBL2 ADAR CDC25B PSRC1 KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 FOXM1 PLOD2 PSMB10 ACTL6A LIG1 CDC20 C1QB UBE2C HCLS1 HLTF RNASEH2A MDC1 HAT1 CDC2 EZH2 RPS6KA1 PSMA4 FANCG AGL NFIL3 ZNF263 PPRC1 HMGB3 BUB1B VRK1 PDIA5 PARN MMP9 CDC6 RFC4 TRIP13 TPST2 AURKA CDC45L RAD51AP1 WASF1 SMC2 DBF4 PIM2 TEAD4 FUSIP1 NEFH APOC1 RAD1 PTPRZ1 CDC7 RAD54L MMP12 SLC7A7 EXO1 NEK2 WDHD1 PARP2 NUDT1 FEN1 CHAF1B MELK PLK4 FST CENPA CENPE PRIM1 EXOSC9 SIP1 BARD1 USP13 CHEK1 ISG15 SNRPG WNT2 BLM POLE2 GINS1 ADAMDEC1 KNTC1 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 ALG3 POLQ PRSS16 PTPRH XPNPEP1 PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT CXCR4 HARS2 POLR3C BAG2 APOL1 TOR1B ATR FAP RPL39L RBBP4 CHEK2 PLAUR SR140 ASXL1 HMG2L1 SUPV3L1 POLR2I SENP5 EIF2C2 DNA2 TWIST1 HOXD11 HMG4L PTPLAD1 LAP3 TMEM48 ASF1B NIF3L1 NOL8 PFDN2 C16orf33 DUSP12 DTL C20orf20 SUV39H1 SCNM1 FBXO5 ISOC2 RPP25 USP18 TIPIN EIF2C3 DCLRE1B NRIP3 ALG6 HERC5 BANP E2F8 FANCE MCM10 DDX47 TCF7L1 DOLPP1 CCDC101 TRMT5 XRN2 DNAJB11 UBE2T TCF19 NAT14 GLIS2 MND1 PCGF6 PARP14 ZNFX1 CDCA7L C1QC PHF19 UHRF1 CREB3L4 NOM1 GEN1 KIAA1804 EID3 ZNF280C PIGX RECQL4 KLF11 ZNF512 C6orf151 ZNF697 FANCM TBK1 ZNF673 SUV39H2 TYMS AGBL3 PSIP1 ZNF26 CCNL1 PIF1 RBM14 UCHL1 GINS2 ZYG11A POLA1 EXOSC10 PKN3 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A HPRT1 NCOA6 AP3M2 NEDD4 CASP8AP2 ZNF251 PMS2L11 RPL30 HNRPK RAD21 STMN1 DNAJA1 RPN1 PXN COPB2 CSE1L ETS2 DHX15 SHC1 PPIF NCBP2 MBTPS1 SMC4 MCM5 AIP RRM2 ARAF FARSA CSTF1 GUSB TRRAP TNFAIP3 E2F1 CTSS MSH6 PLAGL2 TIMELESS CUL2 DMTF1 ADNP2 SLC7A6 POLR2D E2F3 FANCA DNAJB4 AKR1C1 CHD1 PIK3CA TLE2 HHEX ISG20 TTF1 INHBA CCNE2 RECQL ADAM8 IL1RAP FBXO46 PLAU PAX6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PTP4A3 FOXN2 ZNF225 ZNF45 ZNF200 CASK UCHL5IP OPN1SW NCSTN MCM7 AURKB RIPK2 MBD4 HSF2 CDT1 CTSZ MAGOH YARS MCM4 NUP205 SULF1 WEE1 DMXL2 ZNF473 CCNE1 PMS2L1 PMS2L2 FCF1 TGIF2 ZNF227 NAT13 SUPT16H WBP11 USP39 BAZ1A DERL1 UGCGL1 FANCL TOR3A MUS81 UTP6 UPF3B SMC6 TXNL4B POLR3K SIGIRR CCDC59 PAPD1 DBR1 WDR5B FGG FKRP ATG3 ZNF532 ADPGK CDCA3 EIF4EBP1 ETV7 TRMT6 MRPL47 MCM8 MTPN SULF2 SIN3A MTERFD3 ZNF275 EEF2K OMA1 KLHL15 LCOR ASB2 TOR2A E2F7 ALPK2 IRX2 ZNF367 SIX4 PPIL5
GO:0006139	BP	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0597633136094675	0.218572279957488	3380	6.54228456365804	TAF5 TK1 TAF2 CBX3 CAND1 TARDBP DMRTA2 AHCTF1 ILF2 NONO RNPS1 WARS SFRS2 STAT1 SFRS10 AARS RBBP7 HDAC1 TOP2A DDX23 DKC1 ELF3 MCM3 RUVBL1 DNMT1 MYBL2 ADAR PSRC1 KPNA1 MCM2 ERCC3 USP1 IRF1 FOXM1 CTPS ACTL6A UMPS LIG1 ADM HCLS1 HLTF RNASEH2A MDC1 EZH2 TMPO FANCG NFIL3 ZNF263 PPRC1 HMGB3 PARN CDC6 RFC4 TRIP13 CDC45L RAD51AP1 SMC2 DBF4 TEAD4 FUSIP1 RAD1 RAD54L EXO1 WDHD1 PARP2 NUDT1 FEN1 CHAF1B MLF1 FST PRIM1 EXOSC9 SIP1 BARD1 CHEK1 SNRPG BLM POLE2 GINS1 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 POLQ PTTG3 PARP1 HMGN2 PRKDC DUT HARS2 POLR3C ATR RBBP4 SR140 ASXL1 HMG2L1 SUPV3L1 POLR2I EIF2C2 DDX12 DNA2 TWIST1 GMPS HOXD11 HMG4L ASF1B NIF3L1 NOL8 C16orf33 DTL C20orf20 SUV39H1 SCNM1 RPP25 TIPIN EIF2C3 DCLRE1B BANP E2F8 FANCE MCM10 DDX47 TCF7L1 CCDC101 TRMT5 PRTFDC1 XRN2 DNAJB11 TCF19 NAT14 GLIS2 MND1 PCGF6 PARP14 ZNFX1 CDCA7L PHF19 UHRF1 CREB3L4 NOM1 GEN1 EID3 ZNF280C RECQL4 KLF11 ZNF512 C6orf151 ZNF697 FANCM ZNF673 SUV39H2 TYMS PSIP1 ZNF26 CCNL1 PIF1 RBM14 PTHLH GINS2 POLA1 EXOSC10 UPF2 TOPBP1 SNRPB2 CCDC88A HPRT1 NCOA6 CASP8AP2 ZNF251 PMS2L11 HNRPK RAD21 ETS2 DHX15 NCBP2 SMC4 MCM5 RRM2 FARSA CSTF1 TRRAP E2F1 MSH6 PLAGL2 TIMELESS DMTF1 ADNP2 PRPS2 POLR2D E2F3 FANCA CHD1 TLE2 HHEX ISG20 TTF1 INHBA CCNE2 RECQL PAX6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 FOXN2 ZNF225 ZNF45 ZNF200 DDX11 MCM7 RIPK2 MBD4 HSF2 CDT1 MAGOH YARS MCM4 ZNF473 CCNE1 DHODH PMS2L1 PMS2L2 FCF1 TGIF2 ZNF227 SNX6 SUPT16H WBP11 USP39 BAZ1A FANCL GMCL1 MUS81 UTP6 UPF3B SMC6 TXNL4B POLR3K SIGIRR CCDC59 PAPD1 DBR1 ZNF532 ETV7 TRMT6 MCM8 SIN3A MTERFD3 ZNF275 THEX1 LCOR E2F7 IRX2 ZNF367 SIX4
GO:0045931	BP	positive regulation of mitotic cell cycle	0.416666666666667	0.491596040125088	6	4.98668113491422	BIRC5 SPHK1 ASNS
GO:0006260	BP	DNA replication	0.188442211055276	0.360158614646627	199	11.3244643872615	TK1 RBBP7 TOP2A DKC1 MCM3 MCM2 LIG1 RNASEH2A CDC6 RFC4 CDC45L DBF4 EXO1 FEN1 CHAF1B PRIM1 BLM POLE2 GINS1 POLQ DUT ATR RBBP4 DNA2 NOL8 DTL TIPIN MCM10 TYMS RBM14 GINS2 POLA1 CCDC88A NCOA6 PMS2L11 MCM5 RRM2 MSH6 TTF1 CCNE2 MCM7 CDT1 MCM4 PMS2L1 PMS2L2 SUPT16H MCM8
GO:0006261	BP	DNA-dependent DNA replication	0.170103092783505	0.329824747799750	97	6.89847266960541	MCM3 MCM2 CDC6 RFC4 CDC45L EXO1 PRIM1 BLM ATR TIPIN POLA1 CCDC88A PMS2L11 MCM5 MSH6 TTF1 CCNE2 MCM7 CDT1 MCM4 PMS2L1 PMS2L2 MCM8
GO:0006259	BP	DNA metabolic process	0.152838427947598	0.335047304030348	458	13.1301085508441	TK1 NONO RBBP7 TOP2A DKC1 MCM3 RUVBL1 DNMT1 KPNA1 MCM2 ERCC3 USP1 LIG1 RNASEH2A MDC1 FANCG CDC6 RFC4 CDC45L RAD51AP1 SMC2 DBF4 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B PRIM1 CHEK1 BLM POLE2 GINS1 CDKN2A POLQ PTTG3 PARP1 PRKDC DUT ATR RBBP4 SUPV3L1 DNA2 NOL8 DTL TIPIN DCLRE1B FANCE MCM10 XRN2 MND1 UHRF1 GEN1 RECQL4 FANCM TYMS PIF1 RBM14 GINS2 POLA1 TOPBP1 CCDC88A NCOA6 PMS2L11 RAD21 SMC4 MCM5 RRM2 MSH6 FANCA ISG20 TTF1 CCNE2 RECQL MCM7 MBD4 CDT1 MCM4 PMS2L1 PMS2L2 SUPT16H FANCL MUS81 SMC6 MCM8
GO:0006281	BP	DNA repair	0.148979591836735	0.328385549703289	245	9.2079946577834	NONO TOP2A ERCC3 USP1 LIG1 MDC1 FANCG RFC4 RAD51AP1 RAD1 RAD54L EXO1 PARP2 NUDT1 FEN1 CHAF1B CHEK1 BLM POLE2 POLQ PARP1 PRKDC ATR DCLRE1B FANCE UHRF1 GEN1 RECQL4 FANCM TYMS RBM14 POLA1 TOPBP1 NCOA6 PMS2L11 RAD21 MSH6 FANCA RECQL MBD4 PMS2L1 PMS2L2 SUPT16H FANCL MUS81 SMC6
GO:0043283	BP	biopolymer metabolic process	0.0538311265465596	0.208716837671275	4607	5.45115987466403	ACVR1C TAF5 TK1 TAF2 SAE1 CBX3 CAND1 TARDBP DMRTA2 PAK2 ILF2 NONO RNPS1 WARS SFRS2 STAT1 SFRS10 AARS RBBP7 HDAC1 TOP2A CACYBP DDX23 DKC1 ELF3 MCM3 RUVBL1 DNMT1 MYBL2 ADAR CDC25B PSRC1 KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 FOXM1 PLOD2 PSMB10 ACTL6A LIG1 CDC20 UBE2C HCLS1 HLTF RNASEH2A MDC1 HAT1 CDC2 EZH2 RPS6KA1 PSMA4 FANCG AGL NFIL3 ZNF263 PPRC1 HMGB3 BUB1B VRK1 PARN MMP9 CDC6 RFC4 TRIP13 TPST2 AURKA CDC45L RAD51AP1 SMC2 DBF4 PIM2 TEAD4 FUSIP1 RAD1 PTPRZ1 CDC7 RAD54L EXO1 NEK2 WDHD1 PARP2 NUDT1 FEN1 CHAF1B MELK PLK4 FST PRIM1 EXOSC9 SIP1 BARD1 USP13 CHEK1 ISG15 SNRPG WNT2 BLM POLE2 GINS1 TAF1A ZNF165 HOXC6 CDKN2A HOXD10 ALG3 POLQ PRSS16 PTPRH PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT CXCR4 HARS2 POLR3C ATR RBBP4 CHEK2 SR140 ASXL1 HMG2L1 SUPV3L1 POLR2I SENP5 DNA2 TWIST1 HOXD11 HMG4L PTPLAD1 ASF1B NIF3L1 NOL8 C16orf33 DUSP12 DTL C20orf20 SUV39H1 SCNM1 FBXO5 RPP25 USP18 TIPIN DCLRE1B ALG6 HERC5 BANP E2F8 FANCE MCM10 DDX47 TCF7L1 DOLPP1 CCDC101 TRMT5 XRN2 DNAJB11 UBE2T TCF19 NAT14 GLIS2 MND1 PCGF6 PARP14 ZNFX1 CDCA7L PHF19 UHRF1 CREB3L4 NOM1 GEN1 KIAA1804 EID3 ZNF280C PIGX RECQL4 KLF11 ZNF512 C6orf151 ZNF697 FANCM TBK1 ZNF673 SUV39H2 TYMS PSIP1 ZNF26 CCNL1 PIF1 RBM14 UCHL1 GINS2 ZYG11A POLA1 EXOSC10 PKN3 UPF2 TOPBP1 SNRPB2 CCDC88A NCOA6 NEDD4 CASP8AP2 ZNF251 PMS2L11 HNRPK RAD21 RPN1 ETS2 DHX15 SHC1 NCBP2 SMC4 MCM5 RRM2 ARAF FARSA CSTF1 TRRAP TNFAIP3 E2F1 MSH6 PLAGL2 TIMELESS CUL2 DMTF1 ADNP2 POLR2D E2F3 FANCA CHD1 TLE2 HHEX ISG20 TTF1 INHBA CCNE2 RECQL FBXO46 PAX6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PTP4A3 FOXN2 ZNF225 ZNF45 ZNF200 CASK UCHL5IP OPN1SW NCSTN MCM7 AURKB RIPK2 MBD4 HSF2 CDT1 MAGOH YARS MCM4 WEE1 ZNF473 CCNE1 PMS2L1 PMS2L2 FCF1 TGIF2 ZNF227 NAT13 SUPT16H WBP11 USP39 BAZ1A DERL1 UGCGL1 FANCL MUS81 UTP6 UPF3B SMC6 TXNL4B POLR3K CCDC59 PAPD1 DBR1 WDR5B FKRP ATG3 ZNF532 CDCA3 ETV7 TRMT6 MCM8 SIN3A MTERFD3 ZNF275 EEF2K KLHL15 LCOR ASB2 E2F7 ALPK2 IRX2 ZNF367 SIX4 PPIL5
GO:0006270	BP	DNA replication initiation	0.314814814814815	0.39584739066357	27	7.71281762970278	MCM3 MCM2 CDC6 CDC45L TIPIN POLA1 MCM5 CCNE2 MCM7 CDT1 MCM4 MCM8
GO:0030174	BP	regulation of DNA replication initiation	0.4375	0.495515604482557	8	6.0781173456916	CDC6 CDC45L TIPIN CDT1
GO:0006275	BP	regulation of DNA replication	0.232142857142857	0.396329054671392	28	5.48017287804891	CDC6 CDC45L BLM ATR TIPIN CCDC88A TTF1 CDT1
GO:0043226	CC	organelle	0.0535072540929056	0.208316852549820	7513	7.85745939329428	ALG10 ANLN TAF5 POLE4 CBS TAF2 FILIP1L SAE1 BIRC5 CBX3 CAND1 ALMS1 CEP78 TARDBP MPHOSPH9 DMRTA2 PAK2 TMEM22 NOL10 AHCTF1 NUSAP1 PNLDC1 TMEM49 ILF2 NONO RNPS1 LASP1 SFRS2 STAT1 SFRS10 STOM RBBP7 NUDC HDAC1 TOP2A CACYBP IFI30 DDX23 BUB3 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 MTHFD2 ADAR LBR CDC25B PSRC1 RAI14 KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 STCH FOXM1 PLOD2 PSMB10 ACTL6A LIG1 EBP PCK2 CDC20 HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 SPAG5 MTRR CDC2 FAM50A MTF2 EZH2 PSMA4 TMPO SIVA1 FANCG NFIL3 ZNF263 PPRC1 HMGB3 BUB1B DLG7 VRK1 PDIA5 PARN KIAA0649 CDC6 RFC4 TRIP13 TPST2 TOE1 AURKA CDC45L RAD51AP1 NDC80 WASF1 SMC2 DBF4 TEAD4 FUSIP1 NEFH APOC1 KIF11 RAD1 BID CDC7 RAD54L EXO1 NEK2 KIF23 WDHD1 PARP2 FEN1 CHAF1B MLF1 GLDC CENPA CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 CHEK1 LAMP3 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 GRB14 NTS KNTC1 KIF14 NUP155 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 IL15RA ALG3 POLQ SMPD4 NVL ECOP ANP32E SEMA4F EPPK1 PRSS16 PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT NUPR1 HARS2 POLR3C IFI35 TOR1B KIFC1 DCI SPC25 ATR ATP2C1 NCF2 TPX2 RPL39L B4GALT3 RBBP4 CHEK2 HSPA2 ARL6IP1 MKI67 ASXL1 NUP210 HMG2L1 NCAPD3 SUPV3L1 NCAPH POLR2I SENP5 DDX12 APITD1 TWIST1 HOXD11 CDC42EP4 HMG4L NOMO2 LAP3 PRC1 TMEM48 ASF1B NOL8 ZWILCH KIF4A S100PBP CDCA4 C16orf33 PARP12 DUSP12 DTL C20orf20 SUV39H1 ABHD10 SCNM1 KIF20A NUP107 TMEM38B CEP192 FBXO5 ISOC2 RMI1 RPP25 USP18 TIPIN KIF15 DIABLO C3orf52 DCLRE1B DSN1 PALB2 CENPN NCAPG2 SLC15A3 ALG6 STAG3 NARF BANP E2F8 FANCE MCM10 DDX47 TCF7L1 KIF18A CDCA8 ANKRD27 SOAT1 ACOT9 DONSON LDLRAP1 DOLPP1 CCDC101 TRMT5 CENPK XRN2 TXNDC12 DNAJB11 ADPRHL2 PARP9 SLC25A19 TCF19 NAT14 SLC25A33 GLIS2 NUF2 ZIC2 MND1 PCGF6 C17orf49 PARP14 CDCA5 ZNFX1 CDCA7L TMEM32 PHF19 UHRF1 CREB3L4 PRR6 SLFN11 NR2C2AP NOM1 C11orf82 GEN1 SGOL2 EID3 CENPH SASS6 ZNF541 C19orf46 ZNF280C PIGX NEXN RECQL4 KLF11 ZNF512 C6orf151 JPH1 ZNF697 TRIM37 CKAP2 FANCM SUV39H2 MAD2L1 PSIP1 CKAP5 ZNF26 CCNL1 CYP4B1 PIF1 RBM14 COTL1 PTHLH GINS2 POLA1 COX17 EXOSC10 CEP72 PKN3 TXNRD1 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A ARFGAP3 NCOA6 AP3M2 CP110 CASP8AP2 ZNF251 NAPB RPL30 HNRPK RAD21 STMN1 PSAP RPN1 GOLGB1 PXN COPB2 CSE1L HAX1 MFN2 ANP32B ETS2 DHX15 SHC1 PPIF NCBP2 RAE1 MBTPS1 SMC4 MCM5 TMEM106C LPCAT1 KIF22 CSTF1 STAG1 LPIN2 VAPB GUSB TRRAP TNFAIP3 E2F1 CTSS MSH6 PLAGL2 TIMELESS DMTF1 ADNP2 MMD OFD1 PCNT POLR2D E2F3 FANCA CDKN2C RTN2 CHD1 TLE2 HIRIP3 SLC25A14 HHEX ISG20 C1orf107 TTF1 CCNE2 RECQL KRT17 HSD11B1 SYT17 PAX6 HSD17B6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PEX10 SYCP2 PTP4A3 FOXN2 ZNF225 ZNF45 ZNF200 STX2 CASK DDX11 PDIA4 NCSTN MCM7 UCP2 KIF2C THOC5 AURKB EED MBD4 HSF2 CDT1 CTSZ MAGOH IFT20 ODF2 GLUD2 SLC25A17 MCM4 NUP205 SULF1 WEE1 SLC25A44 DMN DMXL2 AXIN1 SMYD2 ZNF473 CCNE1 DHODH MDM1 PMS2L1 FCF1 TGIF2 ZNF227 SUPT16H WBP11 USP39 BAZ1A TEX10 APPL1 DERL1 GOLT1B APPL2 UGCGL1 PARL COQ4 FANCL GMCL1 TOR3A MUS81 RCL1 KTELC1 NCAPG NXT1 UTP6 UPF3B SMC6 TXNL4B POLR3K CCDC59 PAPD1 MYO5C DBR1 BXDC2 CENPQ FA2H CENPO FKRP CEP97 TRIM45 NUP62CL ZNF532 CHST6 CORO1C ETV7 KIF18B TNS4 TRMT6 ZCCHC17 TXNDC11 DTNBP1 MRPL47 MCM8 AIFM2 SULF2 AGPAT6 CIRH1A SIN3A MTERFD3 INOC1 ZNF275 OMA1 LCOR QSOX2 TOR2A E2F7 IRX2 ZNF367 SIX4
GO:0043227	CC	membrane-bound organelle	0.056074062923378	0.21318423381922	6643	8.52017398989949	ALG10 ANLN TAF5 POLE4 CBS TAF2 SAE1 BIRC5 CBX3 CAND1 TARDBP MPHOSPH9 DMRTA2 PAK2 TMEM22 NOL10 AHCTF1 NUSAP1 PNLDC1 TMEM49 ILF2 NONO RNPS1 SFRS2 STAT1 SFRS10 STOM RBBP7 NUDC HDAC1 TOP2A CACYBP IFI30 DDX23 BUB3 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 MTHFD2 ADAR LBR KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 STCH FOXM1 PLOD2 PSMB10 ACTL6A LIG1 EBP PCK2 HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 MTRR CDC2 FAM50A MTF2 EZH2 PSMA4 TMPO SIVA1 FANCG NFIL3 ZNF263 PPRC1 HMGB3 BUB1B DLG7 VRK1 PDIA5 PARN KIAA0649 CDC6 RFC4 TRIP13 TPST2 TOE1 AURKA CDC45L RAD51AP1 NDC80 SMC2 DBF4 TEAD4 FUSIP1 NEFH APOC1 RAD1 BID CDC7 RAD54L EXO1 NEK2 KIF23 WDHD1 PARP2 FEN1 CHAF1B MLF1 GLDC CENPA CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 CHEK1 LAMP3 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 GRB14 KNTC1 KIF14 NUP155 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 IL15RA ALG3 POLQ SMPD4 NVL ECOP ANP32E SEMA4F PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT NUPR1 HARS2 POLR3C IFI35 TOR1B KIFC1 DCI SPC25 ATR ATP2C1 NCF2 TPX2 B4GALT3 RBBP4 CHEK2 HSPA2 ARL6IP1 MKI67 ASXL1 NUP210 HMG2L1 NCAPD3 SUPV3L1 NCAPH POLR2I SENP5 DDX12 APITD1 TWIST1 HOXD11 HMG4L NOMO2 LAP3 PRC1 TMEM48 ASF1B NOL8 KIF4A S100PBP CDCA4 C16orf33 PARP12 DUSP12 DTL C20orf20 SUV39H1 ABHD10 SCNM1 KIF20A NUP107 TMEM38B FBXO5 ISOC2 RMI1 RPP25 USP18 TIPIN DIABLO C3orf52 DCLRE1B DSN1 PALB2 CENPN NCAPG2 SLC15A3 ALG6 STAG3 NARF BANP E2F8 FANCE MCM10 DDX47 TCF7L1 KIF18A CDCA8 ANKRD27 SOAT1 ACOT9 DONSON LDLRAP1 DOLPP1 CCDC101 TRMT5 CENPK XRN2 TXNDC12 DNAJB11 ADPRHL2 PARP9 SLC25A19 TCF19 NAT14 SLC25A33 GLIS2 NUF2 ZIC2 MND1 PCGF6 C17orf49 PARP14 CDCA5 ZNFX1 CDCA7L TMEM32 PHF19 UHRF1 CREB3L4 PRR6 SLFN11 NR2C2AP NOM1 C11orf82 GEN1 SGOL2 EID3 CENPH ZNF541 C19orf46 ZNF280C PIGX RECQL4 KLF11 ZNF512 C6orf151 JPH1 ZNF697 TRIM37 FANCM SUV39H2 MAD2L1 PSIP1 ZNF26 CCNL1 CYP4B1 PIF1 RBM14 PTHLH GINS2 POLA1 COX17 EXOSC10 PKN3 TXNRD1 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A ARFGAP3 NCOA6 AP3M2 CASP8AP2 ZNF251 NAPB HNRPK RAD21 PSAP RPN1 GOLGB1 COPB2 CSE1L HAX1 MFN2 ANP32B ETS2 DHX15 SHC1 PPIF NCBP2 RAE1 MBTPS1 SMC4 MCM5 TMEM106C LPCAT1 KIF22 CSTF1 STAG1 LPIN2 VAPB GUSB TRRAP TNFAIP3 E2F1 CTSS MSH6 PLAGL2 TIMELESS DMTF1 ADNP2 MMD POLR2D E2F3 FANCA CDKN2C RTN2 CHD1 TLE2 HIRIP3 SLC25A14 HHEX ISG20 C1orf107 TTF1 CCNE2 RECQL HSD11B1 SYT17 PAX6 HSD17B6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PEX10 SYCP2 PTP4A3 FOXN2 ZNF225 ZNF45 ZNF200 STX2 CASK DDX11 PDIA4 NCSTN MCM7 UCP2 KIF2C THOC5 AURKB EED MBD4 HSF2 CDT1 CTSZ MAGOH IFT20 GLUD2 SLC25A17 MCM4 NUP205 SULF1 WEE1 SLC25A44 DMXL2 AXIN1 SMYD2 ZNF473 CCNE1 DHODH MDM1 PMS2L1 FCF1 TGIF2 ZNF227 SUPT16H WBP11 USP39 BAZ1A TEX10 APPL1 DERL1 GOLT1B APPL2 UGCGL1 PARL COQ4 FANCL GMCL1 TOR3A MUS81 RCL1 KTELC1 NCAPG NXT1 UTP6 UPF3B SMC6 TXNL4B POLR3K CCDC59 PAPD1 DBR1 BXDC2 CENPQ FA2H CENPO FKRP TRIM45 NUP62CL ZNF532 CHST6 ETV7 TRMT6 ZCCHC17 TXNDC11 DTNBP1 MRPL47 MCM8 AIFM2 SULF2 AGPAT6 CIRH1A SIN3A MTERFD3 INOC1 ZNF275 OMA1 LCOR QSOX2 TOR2A E2F7 IRX2 ZNF367 SIX4
GO:0043228	CC	non-membrane-bound organelle	0.0699939135727328	0.240470888966626	1643	6.65042485095485	ANLN TAF5 FILIP1L BIRC5 CBX3 ALMS1 CEP78 NUSAP1 ILF2 LASP1 STOM NUDC TOP2A BUB3 DKC1 MCM3 DNMT1 MYBL2 CDC25B PSRC1 RAI14 MCM2 CDC20 SPAG5 CDC2 TMPO HMGB3 BUB1B DLG7 CDC6 RFC4 AURKA NDC80 WASF1 SMC2 NEFH KIF11 NEK2 KIF23 CENPA CENPE PRIM1 EXOSC9 CHEK1 BLM KNTC1 KIF14 TAF1A CDKN2A CENPF EPPK1 PARP1 HMGN2 KIFC1 SPC25 ATR TPX2 RPL39L MKI67 HMG2L1 NCAPD3 APITD1 CDC42EP4 HMG4L PRC1 ASF1B NOL8 ZWILCH KIF4A SUV39H1 KIF20A CEP192 FBXO5 TIPIN KIF15 DSN1 CENPN STAG3 NARF DDX47 KIF18A CDCA8 TRMT5 CENPK XRN2 NUF2 CDCA5 NOM1 SGOL2 CENPH SASS6 NEXN CKAP2 SUV39H2 MAD2L1 CKAP5 PIF1 COTL1 POLA1 EXOSC10 CEP72 TOPBP1 CP110 RPL30 RAD21 STMN1 PXN HAX1 RAE1 SMC4 KIF22 TIMELESS OFD1 PCNT CHD1 KRT17 IFI16 SYCP2 CASK DDX11 MCM7 KIF2C AURKB CDT1 ODF2 DMN SUPT16H BAZ1A RCL1 SMC6 MYO5C CENPQ CENPO CEP97 CORO1C KIF18B TNS4 MRPL47 CIRH1A
GO:0043229	CC	intracellular organelle	0.0535286284953395	0.208355715834239	7510	7.8682942077981	ALG10 ANLN TAF5 POLE4 CBS TAF2 FILIP1L SAE1 BIRC5 CBX3 CAND1 ALMS1 CEP78 TARDBP MPHOSPH9 DMRTA2 PAK2 TMEM22 NOL10 AHCTF1 NUSAP1 PNLDC1 TMEM49 ILF2 NONO RNPS1 LASP1 SFRS2 STAT1 SFRS10 STOM RBBP7 NUDC HDAC1 TOP2A CACYBP IFI30 DDX23 BUB3 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 MTHFD2 ADAR LBR CDC25B PSRC1 RAI14 KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 STCH FOXM1 PLOD2 PSMB10 ACTL6A LIG1 EBP PCK2 CDC20 HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 SPAG5 MTRR CDC2 FAM50A MTF2 EZH2 PSMA4 TMPO SIVA1 FANCG NFIL3 ZNF263 PPRC1 HMGB3 BUB1B DLG7 VRK1 PDIA5 PARN KIAA0649 CDC6 RFC4 TRIP13 TPST2 TOE1 AURKA CDC45L RAD51AP1 NDC80 WASF1 SMC2 DBF4 TEAD4 FUSIP1 NEFH APOC1 KIF11 RAD1 BID CDC7 RAD54L EXO1 NEK2 KIF23 WDHD1 PARP2 FEN1 CHAF1B MLF1 GLDC CENPA CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 CHEK1 LAMP3 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 GRB14 NTS KNTC1 KIF14 NUP155 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 IL15RA ALG3 POLQ SMPD4 NVL ECOP ANP32E SEMA4F EPPK1 PRSS16 PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT NUPR1 HARS2 POLR3C IFI35 TOR1B KIFC1 DCI SPC25 ATR ATP2C1 NCF2 TPX2 RPL39L B4GALT3 RBBP4 CHEK2 HSPA2 ARL6IP1 MKI67 ASXL1 NUP210 HMG2L1 NCAPD3 SUPV3L1 NCAPH POLR2I SENP5 DDX12 APITD1 TWIST1 HOXD11 CDC42EP4 HMG4L NOMO2 LAP3 PRC1 TMEM48 ASF1B NOL8 ZWILCH KIF4A S100PBP CDCA4 C16orf33 PARP12 DUSP12 DTL C20orf20 SUV39H1 ABHD10 SCNM1 KIF20A NUP107 TMEM38B CEP192 FBXO5 ISOC2 RMI1 RPP25 USP18 TIPIN KIF15 DIABLO C3orf52 DCLRE1B DSN1 PALB2 CENPN NCAPG2 SLC15A3 ALG6 STAG3 NARF BANP E2F8 FANCE MCM10 DDX47 TCF7L1 KIF18A CDCA8 ANKRD27 SOAT1 ACOT9 DONSON LDLRAP1 DOLPP1 CCDC101 TRMT5 CENPK XRN2 TXNDC12 DNAJB11 ADPRHL2 PARP9 SLC25A19 TCF19 NAT14 SLC25A33 GLIS2 NUF2 ZIC2 MND1 PCGF6 C17orf49 PARP14 CDCA5 ZNFX1 CDCA7L TMEM32 PHF19 UHRF1 CREB3L4 PRR6 SLFN11 NR2C2AP NOM1 C11orf82 GEN1 SGOL2 EID3 CENPH SASS6 ZNF541 C19orf46 ZNF280C PIGX NEXN RECQL4 KLF11 ZNF512 C6orf151 JPH1 ZNF697 TRIM37 CKAP2 FANCM SUV39H2 MAD2L1 PSIP1 CKAP5 ZNF26 CCNL1 CYP4B1 PIF1 RBM14 COTL1 PTHLH GINS2 POLA1 COX17 EXOSC10 CEP72 PKN3 TXNRD1 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A ARFGAP3 NCOA6 AP3M2 CP110 CASP8AP2 ZNF251 NAPB RPL30 HNRPK RAD21 STMN1 PSAP RPN1 GOLGB1 PXN COPB2 CSE1L HAX1 MFN2 ANP32B ETS2 DHX15 SHC1 PPIF NCBP2 RAE1 MBTPS1 SMC4 MCM5 TMEM106C LPCAT1 KIF22 CSTF1 STAG1 LPIN2 VAPB GUSB TRRAP TNFAIP3 E2F1 CTSS MSH6 PLAGL2 TIMELESS DMTF1 ADNP2 MMD OFD1 PCNT POLR2D E2F3 FANCA CDKN2C RTN2 CHD1 TLE2 HIRIP3 SLC25A14 HHEX ISG20 C1orf107 TTF1 CCNE2 RECQL KRT17 HSD11B1 SYT17 PAX6 HSD17B6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PEX10 SYCP2 PTP4A3 FOXN2 ZNF225 ZNF45 ZNF200 STX2 CASK DDX11 PDIA4 NCSTN MCM7 UCP2 KIF2C THOC5 AURKB EED MBD4 HSF2 CDT1 CTSZ MAGOH IFT20 ODF2 GLUD2 SLC25A17 MCM4 NUP205 SULF1 WEE1 SLC25A44 DMN DMXL2 AXIN1 SMYD2 ZNF473 CCNE1 DHODH MDM1 PMS2L1 FCF1 TGIF2 ZNF227 SUPT16H WBP11 USP39 BAZ1A TEX10 APPL1 DERL1 GOLT1B APPL2 UGCGL1 PARL COQ4 FANCL GMCL1 TOR3A MUS81 RCL1 KTELC1 NCAPG NXT1 UTP6 UPF3B SMC6 TXNL4B POLR3K CCDC59 PAPD1 MYO5C DBR1 BXDC2 CENPQ FA2H CENPO FKRP CEP97 TRIM45 NUP62CL ZNF532 CHST6 CORO1C ETV7 KIF18B TNS4 TRMT6 ZCCHC17 TXNDC11 DTNBP1 MRPL47 MCM8 AIFM2 SULF2 AGPAT6 CIRH1A SIN3A MTERFD3 INOC1 ZNF275 OMA1 LCOR QSOX2 TOR2A E2F7 IRX2 ZNF367 SIX4
GO:0043231	CC	intracellular membrane-bound organelle	0.0560909501581087	0.213214115847667	6641	8.5277401003556	ALG10 ANLN TAF5 POLE4 CBS TAF2 SAE1 BIRC5 CBX3 CAND1 TARDBP MPHOSPH9 DMRTA2 PAK2 TMEM22 NOL10 AHCTF1 NUSAP1 PNLDC1 TMEM49 ILF2 NONO RNPS1 SFRS2 STAT1 SFRS10 STOM RBBP7 NUDC HDAC1 TOP2A CACYBP IFI30 DDX23 BUB3 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 MTHFD2 ADAR LBR KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 STCH FOXM1 PLOD2 PSMB10 ACTL6A LIG1 EBP PCK2 HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 MTRR CDC2 FAM50A MTF2 EZH2 PSMA4 TMPO SIVA1 FANCG NFIL3 ZNF263 PPRC1 HMGB3 BUB1B DLG7 VRK1 PDIA5 PARN KIAA0649 CDC6 RFC4 TRIP13 TPST2 TOE1 AURKA CDC45L RAD51AP1 NDC80 SMC2 DBF4 TEAD4 FUSIP1 NEFH APOC1 RAD1 BID CDC7 RAD54L EXO1 NEK2 KIF23 WDHD1 PARP2 FEN1 CHAF1B MLF1 GLDC CENPA CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 CHEK1 LAMP3 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 GRB14 KNTC1 KIF14 NUP155 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 IL15RA ALG3 POLQ SMPD4 NVL ECOP ANP32E SEMA4F PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT NUPR1 HARS2 POLR3C IFI35 TOR1B KIFC1 DCI SPC25 ATR ATP2C1 NCF2 TPX2 B4GALT3 RBBP4 CHEK2 HSPA2 ARL6IP1 MKI67 ASXL1 NUP210 HMG2L1 NCAPD3 SUPV3L1 NCAPH POLR2I SENP5 DDX12 APITD1 TWIST1 HOXD11 HMG4L NOMO2 LAP3 PRC1 TMEM48 ASF1B NOL8 KIF4A S100PBP CDCA4 C16orf33 PARP12 DUSP12 DTL C20orf20 SUV39H1 ABHD10 SCNM1 KIF20A NUP107 TMEM38B FBXO5 ISOC2 RMI1 RPP25 USP18 TIPIN DIABLO C3orf52 DCLRE1B DSN1 PALB2 CENPN NCAPG2 SLC15A3 ALG6 STAG3 NARF BANP E2F8 FANCE MCM10 DDX47 TCF7L1 KIF18A CDCA8 ANKRD27 SOAT1 ACOT9 DONSON LDLRAP1 DOLPP1 CCDC101 TRMT5 CENPK XRN2 TXNDC12 DNAJB11 ADPRHL2 PARP9 SLC25A19 TCF19 NAT14 SLC25A33 GLIS2 NUF2 ZIC2 MND1 PCGF6 C17orf49 PARP14 CDCA5 ZNFX1 CDCA7L TMEM32 PHF19 UHRF1 CREB3L4 PRR6 SLFN11 NR2C2AP NOM1 C11orf82 GEN1 SGOL2 EID3 CENPH ZNF541 C19orf46 ZNF280C PIGX RECQL4 KLF11 ZNF512 C6orf151 JPH1 ZNF697 TRIM37 FANCM SUV39H2 MAD2L1 PSIP1 ZNF26 CCNL1 CYP4B1 PIF1 RBM14 PTHLH GINS2 POLA1 COX17 EXOSC10 PKN3 TXNRD1 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A ARFGAP3 NCOA6 AP3M2 CASP8AP2 ZNF251 NAPB HNRPK RAD21 PSAP RPN1 GOLGB1 COPB2 CSE1L HAX1 MFN2 ANP32B ETS2 DHX15 SHC1 PPIF NCBP2 RAE1 MBTPS1 SMC4 MCM5 TMEM106C LPCAT1 KIF22 CSTF1 STAG1 LPIN2 VAPB GUSB TRRAP TNFAIP3 E2F1 CTSS MSH6 PLAGL2 TIMELESS DMTF1 ADNP2 MMD POLR2D E2F3 FANCA CDKN2C RTN2 CHD1 TLE2 HIRIP3 SLC25A14 HHEX ISG20 C1orf107 TTF1 CCNE2 RECQL HSD11B1 SYT17 PAX6 HSD17B6 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PEX10 SYCP2 PTP4A3 FOXN2 ZNF225 ZNF45 ZNF200 STX2 CASK DDX11 PDIA4 NCSTN MCM7 UCP2 KIF2C THOC5 AURKB EED MBD4 HSF2 CDT1 CTSZ MAGOH IFT20 GLUD2 SLC25A17 MCM4 NUP205 SULF1 WEE1 SLC25A44 DMXL2 AXIN1 SMYD2 ZNF473 CCNE1 DHODH MDM1 PMS2L1 FCF1 TGIF2 ZNF227 SUPT16H WBP11 USP39 BAZ1A TEX10 APPL1 DERL1 GOLT1B APPL2 UGCGL1 PARL COQ4 FANCL GMCL1 TOR3A MUS81 RCL1 KTELC1 NCAPG NXT1 UTP6 UPF3B SMC6 TXNL4B POLR3K CCDC59 PAPD1 DBR1 BXDC2 CENPQ FA2H CENPO FKRP TRIM45 NUP62CL ZNF532 CHST6 ETV7 TRMT6 ZCCHC17 TXNDC11 DTNBP1 MRPL47 MCM8 AIFM2 SULF2 AGPAT6 CIRH1A SIN3A MTERFD3 INOC1 ZNF275 OMA1 LCOR QSOX2 TOR2A E2F7 IRX2 ZNF367 SIX4
GO:0043232	CC	intracellular non-membrane-bound organelle	0.0699939135727328	0.240470888966626	1643	6.65042485095485	ANLN TAF5 FILIP1L BIRC5 CBX3 ALMS1 CEP78 NUSAP1 ILF2 LASP1 STOM NUDC TOP2A BUB3 DKC1 MCM3 DNMT1 MYBL2 CDC25B PSRC1 RAI14 MCM2 CDC20 SPAG5 CDC2 TMPO HMGB3 BUB1B DLG7 CDC6 RFC4 AURKA NDC80 WASF1 SMC2 NEFH KIF11 NEK2 KIF23 CENPA CENPE PRIM1 EXOSC9 CHEK1 BLM KNTC1 KIF14 TAF1A CDKN2A CENPF EPPK1 PARP1 HMGN2 KIFC1 SPC25 ATR TPX2 RPL39L MKI67 HMG2L1 NCAPD3 APITD1 CDC42EP4 HMG4L PRC1 ASF1B NOL8 ZWILCH KIF4A SUV39H1 KIF20A CEP192 FBXO5 TIPIN KIF15 DSN1 CENPN STAG3 NARF DDX47 KIF18A CDCA8 TRMT5 CENPK XRN2 NUF2 CDCA5 NOM1 SGOL2 CENPH SASS6 NEXN CKAP2 SUV39H2 MAD2L1 CKAP5 PIF1 COTL1 POLA1 EXOSC10 CEP72 TOPBP1 CP110 RPL30 RAD21 STMN1 PXN HAX1 RAE1 SMC4 KIF22 TIMELESS OFD1 PCNT CHD1 KRT17 IFI16 SYCP2 CASK DDX11 MCM7 KIF2C AURKB CDT1 ODF2 DMN SUPT16H BAZ1A RCL1 SMC6 MYO5C CENPQ CENPO CEP97 CORO1C KIF18B TNS4 MRPL47 CIRH1A
GO:0043233	CC	organelle lumen	0.0694288913773796	0.236034619559759	893	4.68537395129572	TAF5 TAF2 AHCTF1 ILF2 RNPS1 SFRS2 HDAC1 TOP2A DKC1 RUVBL1 ERCC3 ACTL6A HCLS1 EZH2 PDIA5 TOE1 FUSIP1 WDHD1 CHAF1B EXOSC9 BLM TAF1A CDKN2A CENPF POLQ PARP1 HARS2 POLR3C TOR1B DCI RBBP4 CHEK2 MKI67 SUPV3L1 POLR2I NOL8 KIF4A C20orf20 NARF E2F8 DDX47 XRN2 TXNDC12 DNAJB11 GLIS2 NOM1 CCNL1 RBM14 POLA1 COX17 EXOSC10 P4HA1 TOPBP1 NCOA6 HNRPK PPIF MBTPS1 TRRAP E2F1 POLR2D E2F3 ISG20 IFI16 DDX11 PDIA4 MCM7 EED GLUD2 APPL1 APPL2 UGCGL1 GMCL1 RCL1 KTELC1 POLR3K MRPL47 CIRH1A E2F7
GO:0051276	BP	chromosome organization and biogenesis	0.126420454545455	0.316337164480719	352	8.75379327155043	TAF5 CBX3 NUSAP1 RBBP7 HDAC1 TOP2A BUB3 DKC1 RUVBL1 MCM2 ACTL6A HLTF EZH2 DLG7 NDC80 SMC2 NEFH CHAF1B CENPA CENPE BLM CENPF PTTG3 HMGN2 KIFC1 RBBP4 NCAPD3 NCAPH ASF1B C20orf20 SUV39H1 NCAPG2 STAG3 BANP TCF7L1 CDCA5 CENPH RECQL4 SUV39H2 PIF1 RBM14 SMC4 TRRAP CHD1 HIRIP3 TTF1 SYCP2 DDX11 SUPT16H NCAPG AIFM2 INOC1
GO:0030261	BP	chromosome condensation	0.425	0.466651002243365	20	9.31061204560626	NUSAP1 TOP2A SMC2 NCAPD3 NCAPH NCAPG2 CDCA5 SMC4 NCAPG AIFM2
GO:0008409	MF	5'-3' exonuclease activity	0.75	0.5	4	7.68714349139294	EXO1 FEN1 XRN2
GO:0031047	BP	RNA-mediated gene silencing	0.269230769230769	0.438529009653515	13	4.45782745624267	ADAR EIF2C2 EIF2C3 THEX1
GO:0008152	BP	metabolic process	0.0482992293382939	0.197557588268491	7526	4.50269767755514	ACVR1C ANLN TAF5 CBS TK1 TAF2 SAE1 CDKN3 CBX3 EIF4A2 CAND1 TARDBP DMRTA2 PAK2 AHCTF1 ABCF1 ILF2 NONO RNPS1 WARS SFRS2 STAT1 SFRS10 SEPHS2 AARS STOM RBBP7 HDAC1 AKR1B1 TOP2A ENO2 CACYBP PTDSS1 DDX23 DKC1 ELF3 MCM3 RUVBL1 INSIG1 DNMT1 MYBL2 MTHFD2 ADAR CDC25B PSRC1 SLC20A1 SMS KPNA1 MCM2 ERCC3 PLOD3 CDK4 USP1 IRF1 FOXM1 CTPS PLOD2 PSMB10 ACTL6A UMPS LIG1 EBP PCK2 CDC20 ADM C1QB UBE2C HCLS1 ACOT2 HLTF RNASEH2A MDC1 HAT1 MTRR CDC2 PAFAH1B3 EZH2 RPS6KA1 PSMA4 TMPO FANCG AGL NFIL3 ZNF263 PPRC1 HMGB3 BUB1B VRK1 PDIA5 PARN MMP9 CDC6 RFC4 TRIP13 TPST2 AURKA CDC45L RAD51AP1 WASF1 SMC2 DBF4 PIM2 TEAD4 FUSIP1 NEFH APOC1 RAD1 PTPRZ1 CDC7 RAD54L MMP12 SLC7A7 EXO1 NEK2 WDHD1 PARP2 NUDT1 FEN1 CHAF1B MLF1 MELK GLDC GCHFR PLK4 AOC3 FST CENPA CENPE PRIM1 EXOSC9 SIP1 CA9 BARD1 USP13 CHEK1 ISG15 SNRPG WNT2 CYP27B1 BLM POLE2 GINS1 ADAMDEC1 PLA2G7 KNTC1 KIAA0859 TAF1A ZNF165 HOXC6 CDKN2A CENPF HOXD10 ALG3 POLQ SMPD4 PRSS16 PTPRH XPNPEP1 PTTG3 PARP1 HMGN2 RPN2 PRKDC PSMA6 DUT CXCR4 HARS2 POLR3C BAG2 APOL1 TOR1B DCI ATR ATP2C1 NCF2 FAP INDO RPL39L B4GALT3 RBBP4 CHEK2 PLAUR PXDN SR140 ASXL1 ATP13A3 HMG2L1 SUPV3L1 POLR2I SENP5 EIF2C2 DDX12 DNA2 TWIST1 GMPS HOXD11 HMG4L PTPLAD1 LAP3 TMEM48 ASF1B NIF3L1 NOL8 PFDN2 C16orf33 DUSP12 DTL C20orf20 SUV39H1 SCNM1 FBXO5 ISOC2 RPP25 USP18 THUMPD2 SPHK1 TIPIN EIF2C3 DCLRE1B NRIP3 PLA1A ALG6 HERC5 MOCOS BANP E2F8 FANCE MCM10 DDX47 TCF7L1 SOAT1 ACOT9 LDLRAP1 DOLPP1 CCDC101 TRMT5 PRTFDC1 XRN2 DNAJB11 UBE2T TCF19 NAT14 GLIS2 MND1 PCGF6 PARP14 ZNFX1 CDCA7L C1QC PHF19 UHRF1 CREB3L4 PRR6 LYSMD2 NOM1 GEN1 KIAA1804 EID3 ZNF280C PIGX HAS3 RECQL4 KLF11 ZNF512 C6orf151 ZNF697 FANCM TBK1 ZNF673 SUV39H2 TYMS PLA2G4C AGBL3 PSIP1 ZNF26 CCNL1 PIF1 RBM14 UCHL1 PTHLH GINS2 ZYG11A POLA1 COX17 EXOSC10 PKN3 TXNRD1 P4HA1 UPF2 TOPBP1 SNRPB2 CCDC88A HPRT1 NCOA6 AP3M2 NEDD4 CASP8AP2 ZNF251 PMS2L11 RPL30 HNRPK RAD21 STMN1 PSAP DNAJA1 RPN1 PXN COPB2 CSE1L ETS2 DHX15 SHC1 PPIF NCBP2 MBTPS1 SMC4 MCM5 AIP LPCAT1 RRM2 ARAF FARSA CSTF1 GUSB TRRAP TNFAIP3 E2F1 CTSS MSH6 PLAGL2 TIMELESS CUL2 DMTF1 ADNP2 PRPS2 RBP1 SLC7A6 POLR2D E2F3 MTR FANCA DNAJB4 AKR1C1 CDKN2C CHD1 PIK3CA TLE2 SLC25A14 HHEX ISG20 TTF1 INHBA CCNE2 ASNS RECQL ADAM8 IL1RAP FBXO46 HSD11B1 PLAU PAX6 CD38 HSD17B6 TDO2 FOXJ3 SNRPA1 SFRS6 LHX2 FOXD1 IFI16 PTP4A3 FOXN2 ASS1 ZNF225 ZNF45 ZNF200 CASK UCHL5IP OPN1SW DDX11 NCSTN MCM7 AURKB RIPK2 PCYT2 MBD4 HSF2 CDT1 CTSZ MAGOH GLUD2 YARS MCM4 NUP205 SULF1 WEE1 DMXL2 ZNF473 CCNE1 DHODH PMS2L1 BCAT1 PMS2L2 FCF1 TGIF2 ZNF227 NAT13 SNX6 SUPT16H WBP11 USP39 BAZ1A DERL1 UGCGL1 COQ4 FANCL GMCL1 TOR3A MUS81 UTP6 UPF3B SMC6 TXNL4B POLR3K SIGIRR CCDC59 PAPD1 DBR1 FA2H WDR5B FGG FKRP SLCO4A1 ATG3 FLJ21865 ZNF532 ADPGK CHST6 CDCA3 EIF4EBP1 ETV7 TRMT6 MRPL47 MCM8 AIFM2 MTPN SULF2 AGPAT6 SIN3A MTERFD3 ZNF275 EEF2K AADACL1 OMA1 KLHL15 THEX1 TMEM68 LCOR ATP11C LOC201164 ASB2 TOR2A E2F7 ALPK2 IRX2 ZNF367 SIX4 PPIL5
GO:0008156	BP	negative regulation of DNA replication	0.352941176470588	0.459779358848926	17	6.97108834999297	CDC6 CDC45L BLM ATR TIPIN TTF1 CDT1
GO:0022402	BP	cell cycle process	0.180929095354523	0.362491537912609	409	15.5093187255488	ANLN CDKN3 BIRC5 TARDBP MPHOSPH9 NUSAP1 NUDC BUB3 RUVBL1 CDC25B CDK4 CDC20 UBE2C SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA NDC80 SMC2 DBF4 PIM2 KIF11 RAD1 CDC7 RAD54L EXO1 NEK2 KIF23 MLF1 CENPE BARD1 CHEK1 BLM KNTC1 CDKN2A CENPF KIFC1 SPC25 TPX2 HSPA2 NCAPD3 NCAPH PRC1 ZWILCH CEP55 FBXO5 TIPIN KIF15 DSN1 NCAPG2 STAG3 TCF7L1 CDCA8 NUF2 MND1 CDCA5 C11orf82 SASS6 RECQL4 MAD2L1 CKAP5 POLA1 CP110 RAD21 STMN1 MFN2 SHC1 SMC4 KIF22 STAG1 E2F1 TIMELESS CUL2 CDKN2C INHBA SYCP2 DDX11 KIF2C AURKB CDT1 WEE1 CCNE1 BCAT1 NCAPG TXNL4B CDCA3
GO:0022403	BP	cell cycle phase	0.200301204819277	0.378540566334814	332	15.8733188138994	ANLN CDKN3 BIRC5 TARDBP MPHOSPH9 NUSAP1 NUDC BUB3 RUVBL1 CDC25B CDK4 CDC20 UBE2C SPAG5 CDC2 BUB1B DLG7 CDC6 AURKA NDC80 SMC2 DBF4 PIM2 KIF11 RAD1 CDC7 RAD54L EXO1 NEK2 KIF23 CENPE CHEK1 BLM KNTC1 CDKN2A CENPF KIFC1 SPC25 TPX2 HSPA2 NCAPD3 NCAPH ZWILCH CEP55 FBXO5 TIPIN KIF15 DSN1 NCAPG2 STAG3 TCF7L1 CDCA8 NUF2 MND1 CDCA5 MAD2L1 POLA1 RAD21 SHC1 SMC4 KIF22 STAG1 E2F1 TIMELESS CUL2 CDKN2C INHBA SYCP2 DDX11 KIF2C AURKB CDT1 WEE1 CCNE1 BCAT1 NCAPG TXNL4B CDCA3
GO:0016020	CC	membrane	0.0298309579052038	0.156430443338332	6034	-6.14179309219364	PIGX NEXN NIPA1 LRRC15 HAS3 JPH1 OSMR LAPTM4B PLA2G4C CYP4B1 CLEC2B POLA1 TMEM44 MUC4 CCDC88A FAT ARFGAP3 MCAM AP3M2 NAPB PSAP DNAJA1 RPN1 GOLGB1 PXN COPB2 CSE1L HAX1 MFN2 SHC1 RAE1 MBTPS1 TMEM106C LPCAT1 SDC4 VAPB GBP2 CTSS MMD SLC7A6 RTN2 SLC25A14 MPDZ CCR1 TMEFF1 ADAM8 IL1RAP HSD11B1 SYT17 CD38 PEX10 PTP4A3 GPR176 STX2 CASK OPN1SW NCSTN UCP2 VEGFA TNFRSF10D KLRC4 SLC43A3 SLC25A17 NIPA2 NUP205 TMEM194 SLC25A44 DMXL2 AXIN1 DPY19L4 DHODH KLRB1 FPRL2 CYFIP2 TEX10 APPL1 DERL1 GOLT1B APPL2 PARL TMEM39A LRRC8D NXT1 C1orf27 SIGIRR SLAMF8 FA2H FKRP SLCO4A1 C20orf30 NUP62CL ATG16L1 CHST6 NOMO3 TNS4 TXNDC11 BRI3 DTNBP1 AIFM2 AGPAT6 TMEM173 AADACL1 OMA1 TMEM68 ATP11C QSOX2 TRIM59 SHANK3 ALG10 ACVR1C HS6ST2 CD300LF KIAA1524 CBX3 SLC16A1 MPHOSPH9 CNTLN PAK2 TMEM22 GBP1 PNLDC1 TMEM49 JTB MARCKSL1 STOM ENO2 PTDSS1 RUVBL1 INSIG1 CD14 LBR SLC20A1 MEST EFNA1 TMEM184B KPNA1 PLOD3 SLC6A8 PLSCR1 PLOD2 ACTL6A EBP HCLS1 MDC1 TMPO CD163 CX3CL1 CLCN6 TPST2 C7orf23 MRC1 SLC16A2 PTPRZ1 BID SELL SLC7A7 AOC3 TLR2 CELSR3 CA9 KIAA0133 LAMP3 WNT2 CYP27B1 SYNGR3 KCNS3 ADAMDEC1 GRB14 MICB NUP155 LY96 GPR19 CENPF IL15RA ALG3 TNFSF4 SMPD4 SEMA4F PTPRH PARP1 RPN2 CXCR4 PPAP2C DCI ATP2C1 VEGFC FAP B4GALT3 PLAUR ARL6IP1 TMEM97 ATP13A3 NUP210 LHFPL2 PAQR4 ABHD3 OLFML2B CDC42EP4 SLC38A6 SLC6A10P FAM69A NOMO2 PTPLAD1 NUP85 TMEM48 TNFRSF12A NUP107 TMEM38B NETO2 CKLF C3orf52 SLC15A3 ALG6 NARF KCNMB3 SOAT1 LDLRAP1 DOLPP1 FLVCR1 CLPTM1L SLC25A19 NAT14 SLC25A33 ZIC2 TMEM32 CREB3L4 ZDHHC23 RELT C1orf162 ALG10B GBP5 KRTCAP3 C19orf46 KISS1R
GO:0016021	CC	integral to membrane	0.0304023508137432	0.158532214368051	4424	-4.63692857457221	PIGX NIPA1 LRRC15 HAS3 JPH1 OSMR LAPTM4B CLEC2B TMEM44 MUC4 FAT MCAM PSAP RPN1 GOLGB1 CSE1L MFN2 RAE1 MBTPS1 TMEM106C LPCAT1 SDC4 VAPB MMD SLC7A6 RTN2 SLC25A14 CCR1 TMEFF1 ADAM8 IL1RAP HSD11B1 CD38 GPR176 STX2 OPN1SW NCSTN UCP2 TNFRSF10D KLRC4 SLC43A3 SLC25A17 NIPA2 NUP205 TMEM194 SLC25A44 DPY19L4 KLRB1 FPRL2 TEX10 DERL1 GOLT1B PARL TMEM39A LRRC8D NXT1 C1orf27 SIGIRR SLAMF8 FA2H FKRP SLCO4A1 C20orf30 NUP62CL CHST6 NOMO3 TXNDC11 BRI3 AIFM2 AGPAT6 TMEM173 AADACL1 OMA1 TMEM68 ATP11C QSOX2 TRIM59 ALG10 ACVR1C HS6ST2 CD300LF KIAA1524 SLC16A1 TMEM22 PNLDC1 TMEM49 JTB STOM PTDSS1 INSIG1 LBR SLC20A1 MEST EFNA1 TMEM184B KPNA1 SLC6A8 PLSCR1 EBP TMPO CD163 CX3CL1 CLCN6 TPST2 C7orf23 MRC1 SLC16A2 PTPRZ1 SELL SLC7A7 AOC3 TLR2 CELSR3 CA9 KIAA0133 LAMP3 SYNGR3 KCNS3 ADAMDEC1 NUP155 GPR19 IL15RA ALG3 TNFSF4 SMPD4 SEMA4F PTPRH RPN2 CXCR4 PPAP2C ATP2C1 FAP B4GALT3 PLAUR ARL6IP1 TMEM97 ATP13A3 NUP210 LHFPL2 PAQR4 ABHD3 SLC38A6 SLC6A10P FAM69A NOMO2 PTPLAD1 TMEM48 TNFRSF12A NUP107 TMEM38B NETO2 CKLF C3orf52 SLC15A3 ALG6 KCNMB3 SOAT1 DOLPP1 FLVCR1 CLPTM1L SLC25A19 NAT14 SLC25A33 ZIC2 TMEM32 CREB3L4 ZDHHC23 RELT C1orf162 ALG10B KRTCAP3 C19orf46 KISS1R
GO:0051726	BP	regulation of cell cycle	0.129893238434164	0.324636592411714	281	8.1220995446312	ANLN CDKN3 BIRC5 NUSAP1 BUB3 CKS1B ERCC3 IRF1 UBE2C CDC2 FANCG BUB1B DLG7 CDC6 CDC45L RAD1 CDC7 NEK2 CHEK1 BLM KNTC1 CDKN2A CENPF ATR CHEK2 ZWILCH FBXO5 SPHK1 TIPIN HERC5 BANP CABLES2 MAD2L1 SHC1 TIMELESS CDKN2C INHBA CCNE2 ASNS CDT1 AXIN1
GO:0016043	BP	cellular component organization and biogenesis	0.0579334198011241	0.216368383947563	2313	4.68060031504886	ANLN TAF5 TAF2 BIRC5 CBX3 EIF4A2 NUSAP1 LASP1 STAT1 STOM RBBP7 HDAC1 TOP2A DDX23 BUB3 DKC1 ELF3 RUVBL1 CD14 PSRC1 KPNA1 MCM2 PLSCR1 ACTL6A UBE2C HLTF HAT1 SPAG5 EZH2 BUB1B DLG7 MMP9 AURKA NDC80 WASF1 SMC2 PIM2 FUSIP1 NEFH MRC1 KIF11 BID SLC7A7 KIF23 CHAF1B CENPA CENPE EXOSC9 SIP1 CCL3 BARD1 SNRPG WNT2 BLM KNTC1 KIF14 NUP155 CDKN2A CENPF SEMA4F PTTG3 HMGN2 CXCR4 KIFC1 ATP2C1 RBBP4 ARL6IP1 NUP210 HMG2L1 NCAPD3 NCAPH CDC42EP4 PRC1 TMEM48 ASF1B KIF4A TNFRSF12A C20orf20 SUV39H1 KIF20A NUP107 CKLF KIF15 NCAPG2 STAG3 BANP TCF7L1 KIF18A ANKRD27 LDLRAP1 COL8A2 XRN2 NAT14 CDCA5 LYSMD2 HPS3 CENPH SASS6 NEXN RECQL4 SUV39H2 CKAP5 PIF1 RBM14 EXOSC10 UPF2 CCDC88A FAT HPRT1 ARFGAP3 NCOA6 AP3M2 CP110 NAPB STMN1 PSAP GOLGB1 PXN COPB2 CSE1L MFN2 NCBP2 RAE1 MBTPS1 SMC4 AIP KIF22 TRRAP SLC7A6 PCNT E2F3 FANCA AKR1C1 CHD1 HIRIP3 SLC25A14 HHEX TTF1 IL1RAP PAX6 SFRS6 PEX10 SYCP2 STX2 DDX11 PDIA4 UCP2 KIF2C IFT20 SLC25A17 NUP205 DMXL2 FCF1 SNX6 SUPT16H WBP11 USP39 DERL1 NCAPG NXT1 UTP6 BXDC2 EIF4EBP1 CORO1C KIF18B TRMT6 DTNBP1 AIFM2 MTERFD3 INOC1
GO:0035267	CC	NuA4 histone acetyltransferase complex	0.416666666666667	0.491596040125088	6	4.98668113491422	RUVBL1 ACTL6A TRRAP
GO:0004003	MF	ATP-dependent DNA helicase activity	0.238095238095238	0.374801534783665	21	4.89295054678722	ERCC3 BLM DDX12 PIF1 CHD1 RECQL DDX11