GOname GO GO.term set.means set.sd n.genes z.score lead.genes GO:0042573 BP retinoic acid metabolic process 0.25 0.5 4 7.68257784216871 BCDO2 GO:0031579 BP membrane raft organization and biogenesis 0.25 0.5 4 7.68257784216871 MAL GO:0031638 BP zymogen activation 0.25 0.5 4 7.68257784216871 PRSS3 GO:0006824 BP cobalt ion transport 0.25 0.5 4 7.68257784216871 TCN1 GO:0015889 BP cobalamin transport 0.25 0.5 4 7.68257784216871 TCN1 GO:0019369 BP arachidonic acid metabolic process 0.25 0.5 4 7.68257784216871 HPGD GO:0002221 BP pattern recognition receptor signaling pathway 0.25 0.5 4 7.68257784216871 NOD2 GO:0002224 BP toll-like receptor signaling pathway 0.25 0.5 4 7.68257784216871 NOD2 GO:0015643 MF toxin binding 0.25 0.5 4 7.68257784216871 DSG1 GO:0005497 MF androgen binding 0.25 0.5 4 7.68257784216871 SCGB2A1 GO:0008035 MF high-density lipoprotein binding 0.25 0.5 4 7.68257784216871 APOD GO:0007516 BP hemocyte development 0.214285714285714 0.393397896234722 7 8.68478529840874 BLNK MAL GO:0042640 BP anagen 0.2 0.447213595499958 5 6.83946598330159 SPINK5 GO:0016108 BP tetraterpenoid metabolic process 0.2 0.447213595499958 5 6.83946598330159 BCDO2 GO:0016116 BP carotenoid metabolic process 0.2 0.447213595499958 5 6.83946598330159 BCDO2 GO:0002218 BP activation of innate immune response 0.2 0.447213595499958 5 6.83946598330159 NOD2 GO:0002758 BP innate immune response-activating signal transduction 0.2 0.447213595499958 5 6.83946598330159 NOD2 GO:0004957 MF prostaglandin E receptor activity 0.2 0.447213595499958 5 6.83946598330159 HPGD GO:0042386 BP hemocyte differentiation 0.1875 0.372011904571422 8 8.09862509891258 BLNK MAL GO:0001523 BP retinoid metabolic process 0.181818181818182 0.404519917477945 11 9.20232932382114 BCDO2 RDH12 GO:0016101 BP diterpenoid metabolic process 0.181818181818182 0.404519917477945 11 9.20232932382114 BCDO2 RDH12 GO:0042119 BP neutrophil activation 0.166666666666667 0.408248290463863 6 6.21429895304808 IL8RB GO:0010224 BP response to UV-B 0.166666666666667 0.408248290463863 6 6.21429895304808 IVL GO:0042572 BP retinol metabolic process 0.166666666666667 0.408248290463863 6 6.21429895304808 RDH12 GO:0016538 MF cyclin-dependent protein kinase regulator activity 0.166666666666667 0.408248290463863 6 6.21429895304808 CCND1 GO:0050700 MF CARD domain binding 0.166666666666667 0.408248290463863 6 6.21429895304808 NOD2 GO:0006721 BP terpenoid metabolic process 0.142857142857143 0.363136519601281 14 8.0999170602578 BCDO2 RDH12 GO:0048820 BP hair follicle maturation 0.142857142857143 0.377964473009227 7 5.72624027330092 SPINK5 GO:0006776 BP vitamin A metabolic process 0.142857142857143 0.363136519601281 14 8.0999170602578 BCDO2 RDH12 GO:0018205 BP peptidyl-lysine modification 0.142857142857143 0.377964473009227 7 5.72624027330092 IVL GO:0016165 MF lipoxygenase activity 0.142857142857143 0.243975018237133 7 5.72624027330092 ALOX15B ALOX12 GO:0005501 MF retinoid binding 0.142857142857143 0.363136519601281 14 8.0999170602578 APOD RBP7 GO:0019840 MF isoprenoid binding 0.142857142857143 0.363136519601281 14 8.0999170602578 APOD RBP7 GO:0004499 MF flavin-containing monooxygenase activity 0.142857142857143 0.377964473009227 7 5.72624027330092 FMO2 GO:0031419 MF cobalamin binding 0.142857142857143 0.377964473009227 7 5.72624027330092 TCN1 GO:0004908 MF interleukin-1 receptor activity 0.142857142857143 0.377964473009227 7 5.72624027330092 IL1R2 GO:0004295 MF trypsin activity 0.142857142857143 0.377964473009227 7 5.72624027330092 PRSS3 GO:0045176 BP apical protein localization 0.125 0.353553390593274 8 5.33107225401985 MAL GO:0016045 BP detection of bacterium 0.125 0.353553390593274 8 5.33107225401985 NOD2 GO:0007567 BP parturition 0.125 0.353553390593274 8 5.33107225401985 HPGD GO:0050716 BP positive regulation of interleukin-1 secretion 0.125 0.353553390593274 8 5.33107225401985 NOD2 GO:0050718 BP positive regulation of interleukin-1 beta secretion 0.125 0.353553390593274 8 5.33107225401985 NOD2 GO:0001533 CC cornified envelope 0.125 0.288675134594813 16 7.54117986394139 SCEL CST6 IVL GO:0000307 CC cyclin-dependent protein kinase holoenzyme complex 0.125 0.353553390593274 8 5.33107225401985 CCND1 GO:0019841 MF retinol binding 0.125 0.353553390593274 8 5.33107225401985 RBP7 GO:0035251 MF UDP-glucosyltransferase activity 0.125 0.353553390593274 8 5.33107225401985 GYS2 GO:0004955 MF prostaglandin receptor activity 0.125 0.353553390593274 8 5.33107225401985 HPGD GO:0006775 BP fat-soluble vitamin metabolic process 0.117647058823529 0.332105582077536 17 7.29874952599086 BCDO2 RDH12 GO:0051592 BP response to calcium ion 0.111111111111111 0.333333333333333 9 5.00229550450793 CCND1 GO:0051289 BP protein homotetramerization 0.111111111111111 0.333333333333333 9 5.00229550450793 GPX3 GO:0019370 BP leukotriene biosynthetic process 0.111111111111111 0.274159440276658 18 7.07632551284882 ALOX15B ALOX12 HPGD GO:0043450 BP alkene biosynthetic process 0.111111111111111 0.274159440276658 18 7.07632551284882 ALOX15B ALOX12 HPGD GO:0050704 BP regulation of interleukin-1 secretion 0.111111111111111 0.333333333333333 9 5.00229550450793 NOD2 GO:0050706 BP regulation of interleukin-1 beta secretion 0.111111111111111 0.333333333333333 9 5.00229550450793 NOD2 GO:0030057 CC desmosome 0.111111111111111 0.333333333333333 9 5.00229550450793 DSG1 GO:0019966 MF interleukin-1 binding 0.111111111111111 0.333333333333333 9 5.00229550450793 IL1R2 GO:0004745 MF retinol dehydrogenase activity 0.111111111111111 0.333333333333333 9 5.00229550450793 RDH12 GO:0005154 MF epidermal growth factor receptor binding 0.111111111111111 0.220479275922049 9 5.00229550450793 EREG BTC GO:0042834 MF peptidoglycan binding 0.111111111111111 0.333333333333333 9 5.00229550450793 NOD2 GO:0004602 MF glutathione peroxidase activity 0.111111111111111 0.333333333333333 9 5.00229550450793 GPX3 GO:0046527 MF glucosyltransferase activity 0.111111111111111 0.333333333333333 9 5.00229550450793 GYS2 GO:0005978 BP glycogen biosynthetic process 0.1 0.280305955290694 15 5.78529906313497 PPP1R3C GYS2 GO:0009250 BP glucan biosynthetic process 0.1 0.280305955290694 15 5.78529906313497 PPP1R3C GYS2 GO:0008105 BP asymmetric protein localization 0.1 0.316227766016838 10 4.7229309863758 MAL GO:0045089 BP positive regulation of innate immune response 0.1 0.280305955290694 15 5.78529906313497 EREG NOD2 GO:0002237 BP response to molecule of bacterial origin 0.1 0.316227766016838 10 4.7229309863758 NOD2 GO:0005626 CC insoluble fraction 0.1 0.307793505625546 20 6.68134333065958 MAL GYS2 GO:0008180 CC signalosome 0.1 0.316227766016838 10 4.7229309863758 NOD2 GO:0016494 MF C-X-C chemokine receptor activity 0.1 0.316227766016838 10 4.7229309863758 IL8RB GO:0004953 MF icosanoid receptor activity 0.1 0.316227766016838 10 4.7229309863758 HPGD GO:0004954 MF prostanoid receptor activity 0.1 0.316227766016838 10 4.7229309863758 HPGD GO:0050701 BP interleukin-1 secretion 0.090909090909091 0.301511344577764 11 4.48152812324806 NOD2 GO:0050702 BP interleukin-1 beta secretion 0.090909090909091 0.301511344577764 11 4.48152812324806 NOD2 GO:0006691 BP leukotriene metabolic process 0.090909090909091 0.250540541171609 22 6.34004075018097 ALOX15B ALOX12 HPGD GO:0043449 BP alkene metabolic process 0.090909090909091 0.250540541171609 22 6.34004075018097 ALOX15B ALOX12 HPGD GO:0050777 BP negative regulation of immune response 0.090909090909091 0.301511344577764 11 4.48152812324806 SPINK5 GO:0051668 BP localization within membrane 0.090909090909091 0.301511344577764 11 4.48152812324806 MAL GO:0030593 BP neutrophil chemotaxis 0.090909090909091 0.301511344577764 11 4.48152812324806 IL8RB GO:0030141 CC secretory granule 0.090909090909091 0.291937104060571 33 7.76763319662886 TFF3 SPINK5 CRISP3 GO:0019958 MF C-X-C chemokine binding 0.090909090909091 0.301511344577764 11 4.48152812324806 IL8RB GO:0016918 MF retinal binding 0.090909090909091 0.301511344577764 11 4.48152812324806 RBP7 GO:0045088 BP regulation of innate immune response 0.088235294117647 0.264297069935462 17 5.39968418290869 EREG NOD2 GO:0009746 BP response to hexose stimulus 0.0833333333333333 0.288675134594813 12 4.27004531817516 GYS2 GO:0009749 BP response to glucose stimulus 0.0833333333333333 0.288675134594813 12 4.27004531817516 GYS2 GO:0034284 BP response to monosaccharide stimulus 0.0833333333333333 0.288675134594813 12 4.27004531817516 GYS2 GO:0030216 BP keratinocyte differentiation 0.0769230769230769 0.232047740446129 26 5.77610576524228 SCEL EREG IVL GO:0009408 BP response to heat 0.0769230769230769 0.277350098112615 13 4.08264613562759 CRNN GO:0045787 BP positive regulation of cell cycle 0.0769230769230769 0.232047740446129 26 5.77610576524228 EREG EDN3 CCND1 GO:0042744 BP hydrogen peroxide catabolic process 0.0769230769230769 0.277350098112615 13 4.08264613562759 GPX3 GO:0009595 BP detection of biotic stimulus 0.0769230769230769 0.277350098112615 13 4.08264613562759 NOD2 GO:0045840 BP positive regulation of mitosis 0.0769230769230769 0.187766904049703 13 4.08264613562759 EREG EDN3 GO:0009395 BP phospholipid catabolic process 0.0769230769230769 0.277350098112615 13 4.08264613562759 PLA2G4F GO:0006720 BP isoprenoid metabolic process 0.0740740740740741 0.266880256341812 27 5.6544197846211 BCDO2 RDH12 GO:0030855 BP epithelial cell differentiation 0.0694444444444444 0.24356805378661 36 6.09575608391458 ALOX15B SPINK5 UPK1A GO:0046456 BP icosanoid biosynthetic process 0.0689655172413793 0.220556841193023 29 5.42949320755899 ALOX15B ALOX12 HPGD GO:0004907 MF interleukin receptor activity 0.0625 0.245934688418982 32 5.13092858715282 IL1R2 IL8RB GO:0006800 BP oxygen and reactive oxygen species metabolic process 0.0609756097560976 0.228995686400954 41 5.65649846799465 ALOX12 GPX3 FMO2 GO:0009913 BP epidermal cell differentiation 0.0606060606060606 0.24230584229878 33 5.0401816732647 SPINK5 IVL GO:0001819 BP positive regulation of cytokine production 0.06 0.219848432637882 25 4.33833873947861 EREG NOD2 GO:0031349 BP positive regulation of defense response 0.0576923076923077 0.215727748652002 26 4.24007038793038 EREG NOD2 GO:0019965 MF interleukin binding 0.0526315789473684 0.226294285921414 38 4.63907730779816 IL1R2 IL8RB GO:0016702 MF oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 0.0526315789473684 0.204507477297718 57 5.68510434588054 ALOX15B ALOX12 BBOX1 BCDO2 GO:0051213 MF dioxygenase activity 0.0526315789473684 0.204507477297718 57 5.68510434588054 ALOX15B ALOX12 BBOX1 BCDO2 GO:0004252 MF serine-type endopeptidase activity 0.0520833333333333 0.219015198885048 144 8.9576861695504 KLK10 TMPRSS11B KLK7 PRSS3 TMPRSS11E KLK12 KLK5 PRSS27 GO:0016701 MF oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0.0517241379310345 0.202823386407498 58 5.62657324989113 ALOX15B ALOX12 BBOX1 BCDO2 GO:0048730 BP epidermis morphogenesis 0.0512820512820513 0.223455865030959 39 4.56779816871046 SPINK5 IVL GO:0051259 BP protein oligomerization 0.05 0.219784177651083 60 5.51369647424262 GPX3 UPK1A NOD2 GO:0008544 BP epidermis development 0.05 0.209039419707376 120 7.81240813636037 SCEL CST6 SPINK5 KLK7 KRT32 IVL KLK5 GO:0006690 BP icosanoid metabolic process 0.048780487804878 0.187245762594928 41 4.43272229696351 ALOX15B ALOX12 HPGD GO:0006766 BP vitamin metabolic process 0.0483870967741935 0.216334543207680 62 5.406026528252 BBOX1 BCDO2 RDH12 GO:0008236 MF serine-type peptidase activity 0.0471698113207547 0.208918650740376 159 8.4425398517919 KLK10 TMPRSS11B KLK7 PRSS3 TMPRSS11E KLK12 KLK5 PRSS27 GO:0017171 MF serine hydrolase activity 0.046875 0.208294021448214 160 8.4106533998877 KLK10 TMPRSS11B KLK7 PRSS3 TMPRSS11E KLK12 KLK5 PRSS27 GO:0007398 BP ectoderm development 0.0458015267175573 0.200483853938313 131 7.41023287935014 SCEL CST6 SPINK5 KLK7 KRT32 IVL KLK5 GO:0019748 BP secondary metabolic process 0.0425531914893617 0.204029708888579 47 4.07770067597855 BCDO2 RDH12 GO:0002009 BP morphogenesis of an epithelium 0.0396825396825397 0.18625310782398 63 4.36608565891219 ALOX15B SPINK5 UPK1A GO:0004866 MF endopeptidase inhibitor activity 0.02734375 0.144568237845319 128 4.04242993427205 A2ML1 CSTB CST6 SPINK5 SPINK7 GO:0009888 BP tissue development 0.0212765957446809 0.138270203591306 282 4.42071212585652 SCEL CST6 SPINK5 KLK7 KRT32 IVL KLK5 GO:0004175 MF endopeptidase activity 0.0209497206703911 0.140953904050752 358 4.8952092271423 KLK10 TMPRSS11B KLK7 PRSS3 TMPRSS11E KLK12 KLK5 PRSS27 GO:0005615 CC extracellular space 0.016 0.121546481208583 500 4.05154545050876 A2ML1 EREG GPX3 APOD SCGB1D2 PRSS3 CRISP2 SLURP1 KLK5 GO:0008233 MF peptidase activity 0.0157992565055762 0.122935133913313 538 4.13375179235962 KLK10 TMPRSS11B SPINK5 KLK7 PRSS3 TMPRSS11E KLK12 KLK5 PRSS27 GO:0005576 CC extracellular region 0.0140845070422535 0.114076680516101 1704 6.4813701850282 A2ML1 EREG CST6 BTC EDN3 KLK10 RPTN GPX3 APOD TFF3 SPINK5 TCN1 KLK7 SCGB2A1 SCGB1D2 PRSS3 CRISP3 CRISP2 SOSTDC1 SLURP1 TMPRSS11E KLK12 KLK5 SPINK7 PRSS27 SBSN SFTPG