GOname GO GO.term set.means set.sd n.genes z.score lead.genes GO:0008147 MF structural constituent of bone 0.5 0.577350269189626 4 10.6183598529762 COL1A1 COL1A2 GO:0005583 CC fibrillar collagen 0.409090909090909 0.490824908607021 11 14.3433307380224 COL11A1 COL5A1 COL1A1 COL1A2 COL5A2 GO:0032276 BP regulation of gonadotropin secretion 0.375 0.478713553878169 4 7.90834833240945 INHBA FST GO:0032277 BP negative regulation of gonadotropin secretion 0.375 0.478713553878169 4 7.90834833240945 INHBA FST GO:0046880 BP regulation of follicle-stimulating hormone secretion 0.375 0.478713553878169 4 7.90834833240945 INHBA FST GO:0046882 BP negative regulation of follicle-stimulating hormone secretion 0.375 0.478713553878169 4 7.90834833240945 INHBA FST GO:0017106 MF activin inhibitor activity 0.375 0.478713553878169 4 7.90834833240945 INHBA FST GO:0032274 BP gonadotropin secretion 0.3 0.447213595499958 5 7.02409297417366 INHBA FST GO:0046884 BP follicle-stimulating hormone secretion 0.3 0.447213595499958 5 7.02409297417366 INHBA FST GO:0006907 BP pinocytosis 0.25 0.5 4 5.19833681184269 MRC1 GO:0045684 BP positive regulation of epidermis development 0.25 0.5 4 5.19833681184269 FST GO:0045123 BP cellular extravasation 0.25 0.5 4 5.19833681184269 ITGA1 GO:0002467 BP germinal center formation 0.25 0.5 4 5.19833681184269 TNFSF13B GO:0006534 BP cysteine metabolic process 0.25 0.418330013267038 6 6.36703834763043 CTH CBS GO:0002052 BP positive regulation of neuroblast proliferation 0.25 0.5 4 5.19833681184269 VEGFC GO:0001782 BP B cell homeostasis 0.25 0.5 4 5.19833681184269 TNFSF13B GO:0001527 CC microfibril 0.25 0.5 4 5.19833681184269 MFAP2 GO:0005172 MF vascular endothelial growth factor receptor binding 0.25 0.5 4 5.19833681184269 VEGFC GO:0004992 MF platelet activating factor receptor activity 0.25 0.5 4 5.19833681184269 PDGFRL GO:0042554 BP superoxide release 0.2 0.447213595499958 5 4.60010846155449 NOX4 GO:0031294 BP lymphocyte costimulation 0.2 0.447213595499958 5 4.60010846155449 TNFSF13B GO:0031295 BP T cell costimulation 0.2 0.447213595499958 5 4.60010846155449 TNFSF13B GO:0008045 BP motor axon guidance 0.2 0.447213595499958 5 4.60010846155449 CXCR4 GO:0017114 MF wide-spectrum protease inhibitor activity 0.2 0.447213595499958 5 4.60010846155449 OVOS2 GO:0008131 MF amine oxidase activity 0.2 0.447213595499958 5 4.60010846155449 AOC3 GO:0004287 MF prolyl oligopeptidase activity 0.2 0.447213595499958 5 4.60010846155449 FAP GO:0008133 MF collagenase activity 0.2 0.447213595499958 5 4.60010846155449 MMP1 GO:0003847 MF 1-alkyl-2-acetylglycerophosphocholine esterase activity 0.2 0.447213595499958 5 4.60010846155449 PLA2G7 GO:0015355 MF secondary active monocarboxylate transmembrane transporter activity 0.2 0.447213595499958 5 4.60010846155449 SLC16A1 GO:0008242 MF omega peptidase activity 0.2 0.273861278752583 5 4.60010846155449 UCHL1 TRHDE GO:0008195 MF phosphatidate phosphatase activity 0.2 0.447213595499958 5 4.60010846155449 LPPR4 GO:0050664 MF oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor 0.2 0.447213595499958 5 4.60010846155449 NOX4 GO:0005518 MF collagen binding 0.184210526315789 0.380442955126341 19 8.22481150171425 FN1 NID2 SERPINH1 ITGA1 GO:0030199 BP collagen fibril organization 0.181818181818182 0.404519917477945 11 6.17053239233539 COL5A2 COL12A1 GO:0005581 CC collagen 0.171428571428571 0.36264666693907 35 10.3481882389954 COL11A1 COL10A1 COL5A1 COL1A1 COL1A2 COL5A2 COL12A1 GO:0009070 BP serine family amino acid biosynthetic process 0.166666666666667 0.353553390593274 9 5.08829688845237 CTH CBS GO:0030512 BP negative regulation of transforming growth factor beta receptor signaling pathway 0.166666666666667 0.408248290463863 6 4.15418349314960 HTRA1 GO:0008354 BP germ cell migration 0.166666666666667 0.408248290463863 6 4.15418349314960 CXCR4 GO:0005593 CC FACIT collagen 0.166666666666667 0.408248290463863 6 4.15418349314960 COL12A1 GO:0043205 CC fibril 0.166666666666667 0.408248290463863 6 4.15418349314960 MFAP2 GO:0042708 MF elastase activity 0.166666666666667 0.408248290463863 6 4.15418349314960 MMP12 GO:0042056 MF chemoattractant activity 0.166666666666667 0.408248290463863 6 4.15418349314960 CCL3 GO:0005152 MF interleukin-1 receptor antagonist activity 0.166666666666667 0.408248290463863 6 4.15418349314960 PXDN GO:0030353 MF fibroblast growth factor receptor antagonist activity 0.166666666666667 0.408248290463863 6 4.15418349314960 PXDN GO:0046888 BP negative regulation of hormone secretion 0.136363636363636 0.323334895341432 11 4.53597272319799 INHBA FST GO:0048010 BP vascular endothelial growth factor receptor signaling pathway 0.125 0.310790780254031 12 4.3109946715039 HHEX VEGFC GO:0016638 MF oxidoreductase activity, acting on the CH-NH2 group of donors 0.125 0.341565025531987 16 4.9785368683742 GLDC AOC3 GO:0015026 MF coreceptor activity 0.125 0.341565025531987 16 4.9785368683742 LY96 CXCR4 GO:0042542 BP response to hydrogen peroxide 0.119047619047619 0.312440470520462 21 5.40868635321012 TXNRD1 COL1A1 PXDN GO:0042744 BP hydrogen peroxide catabolic process 0.115384615384615 0.299572344757639 13 4.11124944161102 TXNRD1 PXDN GO:0000097 BP sulfur amino acid biosynthetic process 0.115384615384615 0.299572344757639 13 4.11124944161102 CTH CBS GO:0005201 MF extracellular matrix structural constituent 0.106741573033708 0.296493811375315 89 9.89680404594072 FN1 COL11A1 COL8A2 COL5A1 COL1A1 COL1A2 MFAP2 WNT2 COMP COL5A2 COL12A1 GO:0030574 BP collagen catabolic process 0.1 0.307793505625546 20 4.35431034664037 MMP1 MMP3 GO:0044254 BP multicellular organismal protein catabolic process 0.1 0.307793505625546 20 4.35431034664037 MMP1 MMP3 GO:0044256 BP protein digestion 0.1 0.307793505625546 20 4.35431034664037 MMP1 MMP3 GO:0044259 BP multicellular organismal macromolecule metabolic process 0.1 0.307793505625546 20 4.35431034664037 MMP1 MMP3 GO:0044266 BP multicellular organismal macromolecule catabolic process 0.1 0.307793505625546 20 4.35431034664037 MMP1 MMP3 GO:0044268 BP multicellular organismal protein metabolic process 0.1 0.307793505625546 20 4.35431034664037 MMP1 MMP3 GO:0005164 MF tumor necrosis factor receptor binding 0.1 0.307793505625546 20 4.35431034664037 TNFSF4 TNFSF13B GO:0006817 BP phosphate transport 0.097560975609756 0.277099442753581 82 8.59412278419848 SLC20A1 COL11A1 COL10A1 COL8A2 COL5A1 COL1A1 COL1A2 COL5A2 COL12A1 CTHRC1 GO:0009069 BP serine family amino acid metabolic process 0.0961538461538462 0.283521807599725 26 4.7528806183234 CTH CBS GLDC GO:0032813 MF tumor necrosis factor receptor superfamily binding 0.0952380952380952 0.300792603759119 21 4.22530512806604 TNFSF4 TNFSF13B GO:0000302 BP response to reactive oxygen species 0.0925925925925926 0.278631167738513 27 4.64283406619899 TXNRD1 COL1A1 PXDN GO:0044243 BP multicellular organismal catabolic process 0.090909090909091 0.29424494316825 22 4.10464388261364 MMP1 MMP3 GO:0016339 BP calcium-dependent cell-cell adhesion 0.090909090909091 0.29424494316825 22 4.10464388261364 PCDHB10 PCDHB16 GO:0032963 BP collagen metabolic process 0.090909090909091 0.29424494316825 22 4.10464388261364 MMP1 MMP3 GO:0044420 CC extracellular matrix part 0.0876288659793814 0.270130266398903 97 8.28812930326793 COL11A1 COL10A1 COL8A2 COL5A1 COL1A1 COL1A2 MFAP2 NID2 COL5A2 COL12A1 GO:0008201 MF heparin binding 0.0705128205128205 0.251287063226876 78 5.78525470506926 FN1 COL5A1 THBS1 THBS2 CCL8 RSPO3 GO:0030198 BP extracellular matrix organization and biogenesis 0.0697674418604651 0.233538906436359 43 4.23764802590256 COL11A1 COL8A2 COL5A2 COL12A1 GO:0005539 MF glycosaminoglycan binding 0.065 0.242618293546955 100 5.95567487742535 FN1 COL5A1 THBS1 THBS2 TNFAIP6 CCL8 RSPO3 GO:0005578 CC proteinaceous extracellular matrix 0.0633333333333333 0.233460707390358 300 10.0657962577152 COCH FN1 COL11A1 CSPG4 COL10A1 COL8A2 COL5A1 COL1A1 SPOCK1 COL1A2 THBS2 MFAP2 NID2 MMP1 MMP12 LTBP2 WNT2 COMP MMP3 COL5A2 COL12A1 CTHRC1 GO:0030247 MF polysaccharide binding 0.0631067961165049 0.239275987693486 103 5.83599207243141 FN1 COL5A1 THBS1 THBS2 TNFAIP6 CCL8 RSPO3 GO:0043062 BP extracellular structure organization and biogenesis 0.0625 0.230231034211125 80 5.08056266782055 COL11A1 COL8A2 COL5A2 PCDHB10 COL12A1 PCDHB16 GO:0031012 CC extracellular matrix 0.0622950819672131 0.231672930768213 305 9.9525146819392 COCH FN1 COL11A1 CSPG4 COL10A1 COL8A2 COL5A1 COL1A1 SPOCK1 COL1A2 THBS2 MFAP2 NID2 MMP1 MMP12 LTBP2 WNT2 COMP MMP3 COL5A2 COL12A1 CTHRC1 GO:0006820 BP anion transport 0.0617977528089888 0.22947033976329 178 7.49993142439862 SLC20A1 COL11A1 COL10A1 COL8A2 COL5A1 COL1A1 SLC16A1 COL1A2 WNT2 SLC4A3 COL5A2 COL12A1 CTHRC1 GO:0015698 BP inorganic anion transport 0.06 0.223756819100468 150 6.63889784519165 SLC20A1 COL11A1 COL10A1 COL8A2 COL5A1 COL1A1 COL1A2 WNT2 COL5A2 COL12A1 CTHRC1 GO:0001871 MF pattern binding 0.0570175438596491 0.228100776612573 114 5.43463540612038 FN1 COL5A1 THBS1 THBS2 TNFAIP6 CCL8 RSPO3 GO:0004222 MF metalloendopeptidase activity 0.0485436893203883 0.215962995046357 103 4.22880921850503 MMP1 MMP12 MMP3 ADAMDEC1 FAP GO:0006954 BP inflammatory response 0.0396551724137931 0.188730648928906 290 5.48245110634458 FN1 CCR1 CXCL11 CD163 AOC3 CCL3 TNFAIP6 SELE PLA2G7 LY96 CXCR4 CCL8 NOX4 GO:0005125 MF cytokine activity 0.0393013100436681 0.183129330792535 229 4.80385546669888 SPP1 INHBA IL24 CXCL11 CCL3 TNFSF4 VEGFC PXDN CCL8 GREM1 TNFSF13B GO:0044421 CC extracellular region part 0.0389182058047493 0.182098123159112 758 8.77467297099095 COCH PTHLH FN1 SPP1 COL11A1 CSPG4 INHBA ANGPT2 COL10A1 GRP IL24 CXCL11 COL8A2 COL5A1 COL1A1 HTRA1 SPOCK1 COL1A2 THBS2 MFAP2 NID2 MMP1 MMP12 LTBP2 CCL3 WNT2 COMP MMP3 TNFSF4 SULF1 CCL8 GREM1 COL5A2 TNFSF13B COL12A1 CTHRC1 GO:0006928 BP cell motility 0.0379403794037940 0.176536997972427 369 5.83878462839156 NEXN VIM FN1 TPM1 CSPG4 ENPEP PAX6 FPRL2 THBS1 SPOCK1 SELL MMP12 CCL3 WNT2 CXCR4 VEGFC ITGA1 KISS1R GO:0051674 BP localization of cell 0.0379403794037940 0.176536997972427 369 5.83878462839156 NEXN VIM FN1 TPM1 CSPG4 ENPEP PAX6 FPRL2 THBS1 SPOCK1 SELL MMP12 CCL3 WNT2 CXCR4 VEGFC ITGA1 KISS1R GO:0030246 MF carbohydrate binding 0.0362595419847328 0.184718221268923 262 4.60566477584279 FN1 COL5A1 THBS1 THBS2 MRC1 SELL TNFAIP6 SELE CCL8 RSPO3 GO:0009611 BP response to wounding 0.0305623471882641 0.166921158594811 409 4.51652625408655 FN1 CCR1 CXCL11 THBS1 CD163 AOC3 CCL3 TNFAIP6 SELE PLA2G7 LY96 CXCR4 CCL8 NOX4 GO:0007155 BP cell adhesion 0.0297532656023222 0.162377225780761 689 5.68063879833285 DSG2 FN1 SPP1 COL11A1 CCR1 COL8A2 EPDR1 COL5A1 THBS1 SPOCK1 THBS2 NELL2 NID2 SELL AOC3 COMP TNFAIP6 ADAMDEC1 SELE ITGA1 AMIGO2 PCDHB10 COL12A1 PCDHB16 GO:0022610 BP biological adhesion 0.0297532656023222 0.162377225780761 689 5.68063879833285 DSG2 FN1 SPP1 COL11A1 CCR1 COL8A2 EPDR1 COL5A1 THBS1 SPOCK1 THBS2 NELL2 NID2 SELL AOC3 COMP TNFAIP6 ADAMDEC1 SELE ITGA1 AMIGO2 PCDHB10 COL12A1 PCDHB16 GO:0005576 CC extracellular region 0.0293427230046948 0.160798184948998 1704 9.05417710370556 COCH PTHLH FN1 SPP1 GABBR1 STC2 FCGR3B COL11A1 APOC1 CSPG4 INHBA ANGPT2 COL10A1 GRP IL24 CXCL11 COL8A2 EPDR1 COL5A1 COL1A1 THBS1 HTRA1 SPOCK1 COL1A2 THBS2 NELL2 MFAP2 TNFRSF1B CD163 NID2 MMP1 MMP12 LTBP2 FST CCL3 PDGFRL WNT2 COMP MMP3 TNFAIP6 ADAMDEC1 PLA2G7 NTS LY96 TNFSF4 VEGFC PXDN SULF1 OLFML2B CCL8 PLXDC1 GREM1 PLA1A COL5A2 TNFSF13B COL12A1 CTHRC1 RSPO3 OVOS2 GO:0005615 CC extracellular space 0.029 0.157189111689288 500 4.62377868222097 PTHLH SPP1 INHBA ANGPT2 GRP IL24 CXCL11 HTRA1 SPOCK1 MMP1 LTBP2 CCL3 MMP3 TNFSF4 SULF1 CCL8 GREM1 TNFSF13B GO:0005198 MF structural molecule activity 0.0277777777777778 0.152262686865290 648 4.94503872533507 VIM FN1 TPM1 TUBB2B ACTG2 ROCK2 COL11A1 COL10A1 SYNC1 COL8A2 COL5A1 COL1A1 THBS1 COL1A2 THBS2 NELL2 MFAP2 WNT2 COMP COL5A2 COL12A1 CTHRC1 TMEM178 GO:0005509 MF calcium ion binding 0.0268378063010502 0.156191271037959 857 5.41971899222099 DSG2 PTHLH ENPEP COL10A1 EMR2 EPDR1 THBS1 SPOCK1 THBS2 NELL2 PLCB4 NID2 MRC1 MMP1 MMP12 LTBP2 AOC3 COMP MMP3 CLGN ATP2B1 PXDN SULF1 ITGA1 PCDHB10 PCDHB16 GO:0009605 BP response to external stimulus 0.0263157894736842 0.152296789113673 608 4.38524486935567 FN1 STC2 INHBA CCR1 CXCL11 FPRL2 COL1A1 THBS1 CD163 AOC3 CCL3 TNFAIP6 SELE PLA2G7 LY96 CXCR4 CCL8 ITGA1 NOX4 GO:0044424 CC intracellular part 0.00750717597703687 0.077208038159282 9058 -4.28460981709179 NEXN KIAA1524 MLXIP CAPRIN2 UCHL1 VIM PTHLH FN1 TPM1 CHSY3 TXNRD1 TUBB2B TRAF5 WARS ACTG2 PLOD2 TNFAIP3 ROCK2 E2F3 GUCY1B3 COL11A1 PIK3CA APOC1 HHEX ENPEP SIP1 HSD11B1 SYT17 PAX6 PRKD1 COL10A1 CTH LHX2 STX2 POLQ REV3L HSF2 KHDRBS3 CTSZ DMXL2 SMYD2 DUSP10 FCF1 ABHD10 IGF2BP2 CYP26B1 SYNC1 COL8A2 GUCY1A3 MTERFD3 ZNF275 SHANK3 IRX2 ZNF780A CBS FILIP1L AKAP12 COL5A1 COL1A1 IFI44 PNLDC1 RAI14 COL1A2 PDIA5 GLDC PLAG1 WNT2 CYP27B1 CLGN GRB14 NTS KIF14 HOXC6 HOXD10 SERPINH1 CEP170 CXCR4 SULF1 PLXDC1 DDX58 NOX4 SOAT1 COL5A2 AMIGO2 MYEF2 ZIC2 PNPT1 ACAD11 COL12A1 CTHRC1 PRR6 PPP1R14A TCEAL7 L3MBTL3 EID3 GO:0005622 CC intracellular 0.00748550342646284 0.0768203311007321 9485 -4.56538550739129 NEXN KIAA1524 MLXIP CAPRIN2 UCHL1 VIM PTHLH FN1 TPM1 CHSY3 TXNRD1 TUBB2B TRAF5 WARS ACTG2 PLOD2 TNFAIP3 ROCK2 E2F3 GUCY1B3 COL11A1 PIK3CA APOC1 HHEX ENPEP SIP1 HSD11B1 SYT17 PAX6 PRKD1 COL10A1 CTH LHX2 STX2 POLQ REV3L HSF2 KHDRBS3 CTSZ DMXL2 SMYD2 DUSP10 FCF1 ABHD10 IGF2BP2 CYP26B1 SYNC1 COL8A2 GUCY1A3 FSD1L MTERFD3 ZNF275 TBC1D24 SHANK3 IRX2 RASGEF1A ZNF780A ARL5B CBS FILIP1L AKAP12 COL5A1 COL1A1 IFI44 PNLDC1 RAI14 COL1A2 PDIA5 GLDC PLAG1 WNT2 CYP27B1 CLGN GRB14 NTS KIF14 HOXC6 HOXD10 SERPINH1 CEP170 CXCR4 SULF1 CHN1 PLXDC1 DDX58 NOX4 SOAT1 COL5A2 AMIGO2 MYEF2 ZIC2 PNPT1 ACAD11 COL12A1 CTHRC1 PRR6 PPP1R14A TCEAL7 L3MBTL3 EID3 GO:0043229 CC intracellular organelle 0.0066577896138482 0.072681558448583 7510 -4.62044630424429 NEXN MLXIP CAPRIN2 VIM PTHLH TPM1 CHSY3 TXNRD1 TUBB2B ACTG2 PLOD2 TNFAIP3 ROCK2 E2F3 APOC1 HHEX ENPEP SIP1 HSD11B1 SYT17 PAX6 PRKD1 LHX2 STX2 POLQ REV3L HSF2 KHDRBS3 CTSZ DMXL2 SMYD2 DUSP10 FCF1 ABHD10 CYP26B1 SYNC1 MTERFD3 ZNF275 IRX2 ZNF780A CBS FILIP1L AKAP12 PNLDC1 RAI14 PDIA5 GLDC PLAG1 WNT2 CYP27B1 CLGN GRB14 NTS KIF14 HOXC6 HOXD10 SERPINH1 CEP170 SULF1 NOX4 SOAT1 AMIGO2 MYEF2 ZIC2 PNPT1 ACAD11 PRR6 TCEAL7 L3MBTL3 EID3 GO:0043226 CC organelle 0.00665513110608279 0.0726671656629137 7513 -4.6256456034627 NEXN MLXIP CAPRIN2 VIM PTHLH TPM1 CHSY3 TXNRD1 TUBB2B ACTG2 PLOD2 TNFAIP3 ROCK2 E2F3 APOC1 HHEX ENPEP SIP1 HSD11B1 SYT17 PAX6 PRKD1 LHX2 STX2 POLQ REV3L HSF2 KHDRBS3 CTSZ DMXL2 SMYD2 DUSP10 FCF1 ABHD10 CYP26B1 SYNC1 MTERFD3 ZNF275 IRX2 ZNF780A CBS FILIP1L AKAP12 PNLDC1 RAI14 PDIA5 GLDC PLAG1 WNT2 CYP27B1 CLGN GRB14 NTS KIF14 HOXC6 HOXD10 SERPINH1 CEP170 SULF1 NOX4 SOAT1 AMIGO2 MYEF2 ZIC2 PNPT1 ACAD11 PRR6 TCEAL7 L3MBTL3 EID3 GO:0043231 CC intracellular membrane-bound organelle 0.00617376901069116 0.070226479008991 6641 -4.69562784544215 MLXIP CAPRIN2 PTHLH CHSY3 TXNRD1 PLOD2 TNFAIP3 E2F3 APOC1 HHEX SIP1 HSD11B1 SYT17 PAX6 PRKD1 LHX2 STX2 POLQ REV3L HSF2 KHDRBS3 CTSZ DMXL2 SMYD2 DUSP10 FCF1 ABHD10 CYP26B1 MTERFD3 ZNF275 IRX2 ZNF780A CBS PNLDC1 PDIA5 GLDC PLAG1 WNT2 CYP27B1 CLGN GRB14 KIF14 HOXC6 HOXD10 SERPINH1 SULF1 NOX4 SOAT1 AMIGO2 MYEF2 ZIC2 PNPT1 ACAD11 PRR6 TCEAL7 L3MBTL3 EID3 GO:0043227 CC membrane-bound organelle 0.00617191028149932 0.0702159868231538 6643 -4.69900006419716 MLXIP CAPRIN2 PTHLH CHSY3 TXNRD1 PLOD2 TNFAIP3 E2F3 APOC1 HHEX SIP1 HSD11B1 SYT17 PAX6 PRKD1 LHX2 STX2 POLQ REV3L HSF2 KHDRBS3 CTSZ DMXL2 SMYD2 DUSP10 FCF1 ABHD10 CYP26B1 MTERFD3 ZNF275 IRX2 ZNF780A CBS PNLDC1 PDIA5 GLDC PLAG1 WNT2 CYP27B1 CLGN GRB14 KIF14 HOXC6 HOXD10 SERPINH1 SULF1 NOX4 SOAT1 AMIGO2 MYEF2 ZIC2 PNPT1 ACAD11 PRR6 TCEAL7 L3MBTL3 EID3