GOname GO GO.term set.means set.sd n.genes z.score lead.genes GO:0019439 BP aromatic compound catabolic process 0.0625 0.25 16 4.53139536580932 GCH1 GO:0006996 BP organelle organization and biogenesis 0.0120259019426457 0.104720365182823 1081 5.6944830795822 RPS6KA5 PTTG1 ZWINT CKS2 TTK MPHOSPH1 HIST1H1C EXOSC8 MIS12 RACGAP1 NOP5/NOP58 KPNA2 BRCA1 TIMM8A NCAPG GO:0000278 BP mitotic cell cycle 0.0280528052805281 0.152371443535258 303 8.32436961276812 PTTG1 ZWINT TTK MPHOSPH1 CCNB1 MIS12 KPNA2 CCNA2 CDT1 NCAPG FAM33A GO:0006259 BP DNA metabolic process 0.0218340611353712 0.126228400788127 458 7.70354038693009 PCNA RPA2 PTTG1 GMNN ORC6L KPNA2 RRM1 MCM5 RRM2 MCM6 BRCA1 RAD51 PSMC3IP RPA3 CDT1 GO:0006260 BP DNA replication 0.0376884422110553 0.166171030966320 199 9.3391819986585 PCNA RPA2 GMNN ORC6L RRM1 MCM5 RRM2 MCM6 RAD51 RPA3 CDT1 GO:0006261 BP DNA-dependent DNA replication 0.0515463917525773 0.197438493619878 97 9.1168491186923 PCNA RPA2 GMNN MCM5 MCM6 RAD51 CDT1 GO:0007049 BP cell cycle 0.0195530726256983 0.125303865534222 716 8.5194159242784 PTTG1 ZWINT CKS2 TTK MPHOSPH1 CCNB1 GMNN MIS12 RACGAP1 KPNA2 MCM6 CCNA2 BRCA1 RAD51 PSMC3IP CDT1 RBM7 NCAPG FAM33A GO:0022402 BP cell cycle process 0.0305623471882641 0.155519139009958 409 10.6877935272576 PTTG1 ZWINT CKS2 TTK MPHOSPH1 CCNB1 MIS12 RACGAP1 KPNA2 CCNA2 BRCA1 RAD51 PSMC3IP CDT1 RBM7 NCAPG FAM33A GO:0022403 BP cell cycle phase 0.0301204819277108 0.152509671633510 332 9.4498038061593 PTTG1 ZWINT CKS2 MPHOSPH1 CCNB1 MIS12 KPNA2 CCNA2 RAD51 PSMC3IP CDT1 RBM7 NCAPG FAM33A GO:0031032 BP actomyosin structure organization and biogenesis 0.0769230769230769 0.277350098112615 13 5.0788943275622 RACGAP1 GO:0051276 BP chromosome organization and biogenesis 0.015625 0.121294801104288 352 4.47779398332644 RPS6KA5 PTTG1 ZWINT HIST1H1C MIS12 NCAPG GO:0000279 BP M phase 0.0353159851301115 0.166331109058219 269 10.1321886842695 PTTG1 ZWINT CKS2 MPHOSPH1 CCNB1 MIS12 KPNA2 CCNA2 RAD51 PSMC3IP RBM7 NCAPG FAM33A GO:0007126 BP meiosis 0.036231884057971 0.156215362742248 69 5.24473850809345 CKS2 RAD51 PSMC3IP RBM7 GO:0051321 BP meiotic cell cycle 0.0352112676056338 0.154085868035879 71 5.15573969064082 CKS2 RAD51 PSMC3IP RBM7 GO:0051327 BP M phase of meiotic cell cycle 0.036231884057971 0.156215362742248 69 5.24473850809345 CKS2 RAD51 PSMC3IP RBM7 GO:0051726 BP regulation of cell cycle 0.0231316725978648 0.141416862604776 281 6.41930967188008 ZWINT CKS2 TTK MPHOSPH1 GMNN CCNA2 BRCA1 CDT1 GO:0045776 BP negative regulation of blood pressure 0.142857142857143 0.377964473009227 7 7.06240725178827 GCH1 GO:0042311 BP vasodilation 0.0555555555555556 0.235702260395516 18 4.24290944923179 GCH1 GO:0048015 BP phosphoinositide-mediated signaling 0.03 0.171446607997765 100 5.12478776669354 PCNA ZWINT CKS2 GO:0006544 BP glycine metabolic process 0.0714285714285714 0.267261241912424 14 4.87751953935726 DHFR GO:0009070 BP serine family amino acid biosynthetic process 0.111111111111111 0.333333333333333 9 6.18700081393101 DHFR GO:0006809 BP nitric oxide biosynthetic process 0.0526315789473684 0.229415733870562 19 4.11546907178241 GCH1 GO:0017038 BP protein import 0.0238095238095238 0.127493445927933 105 4.03525623665531 NOP5/NOP58 KPNA2 CSE1L TIMM8A GO:0046209 BP nitric oxide metabolic process 0.0526315789473684 0.229415733870562 19 4.11546907178241 GCH1 GO:0030307 BP positive regulation of cell growth 0.142857142857143 0.377964473009227 7 7.06240725178827 PRSS2 GO:0045785 BP positive regulation of cell adhesion 0.0714285714285714 0.267261241912424 14 4.87751953935726 PRSS2 GO:0045793 BP positive regulation of cell size 0.125 0.353553390593274 8 6.58429189674531 PRSS2 GO:0007017 BP microtubule-based process 0.0251256281407035 0.148636426114745 199 5.92914875571324 ZWINT CKS2 TTK MPHOSPH1 KPNA2 BRCA1 GO:0007346 BP regulation of mitotic cell cycle 0.05 0.199575821367660 60 6.93237766135425 ZWINT TTK CCNA2 CDT1 GO:0000226 BP microtubule cytoskeleton organization and biogenesis 0.0393258426966292 0.188063080282853 89 6.51999442489326 ZWINT CKS2 TTK BRCA1 GO:0007059 BP chromosome segregation 0.0666666666666667 0.234098825044052 60 9.4055173242342 PTTG1 ZWINT MIS12 BRCA1 NCAPG GO:0000075 BP cell cycle checkpoint 0.0603448275862069 0.211045563528489 58 8.32458256112263 ZWINT TTK CCNA2 BRCA1 CDT1 GO:0000086 BP G2/M transition of mitotic cell cycle 0.0588235294117647 0.242535625036333 17 4.38100899154288 CCNB1 GO:0000087 BP M phase of mitotic cell cycle 0.03125 0.163696357884166 208 7.76354317578805 PTTG1 ZWINT MPHOSPH1 CCNB1 MIS12 CCNA2 NCAPG FAM33A GO:0007067 BP mitosis 0.0315533980582524 0.164463694750045 206 7.80944281232983 PTTG1 ZWINT MPHOSPH1 CCNB1 MIS12 CCNA2 NCAPG FAM33A GO:0031577 BP spindle checkpoint 0.142857142857143 0.377964473009227 7 7.06240725178827 TTK GO:0051301 BP cell division 0.0379464285714286 0.182501985456893 224 9.99074556756501 PTTG1 ZWINT CKS2 MPHOSPH1 CCNB1 MIS12 RACGAP1 CCNA2 NCAPG FAM33A GO:0007405 BP neuroblast proliferation 0.0588235294117647 0.242535625036333 17 4.38100899154288 RACGAP1 GO:0007093 BP mitotic cell cycle checkpoint 0.0833333333333333 0.265334315252616 30 8.39150749120517 ZWINT TTK CCNA2 GO:0007094 BP mitotic cell cycle spindle assembly checkpoint 0.166666666666667 0.408248290463863 6 7.65365637502761 TTK GO:0007127 BP meiosis I 0.0517241379310345 0.204626296409494 29 4.99250636099438 CKS2 RAD51 GO:0006275 BP regulation of DNA replication 0.0892857142857143 0.273982002266823 28 8.70922734892356 PCNA GMNN CDT1 GO:0008156 BP negative regulation of DNA replication 0.088235294117647 0.264297069935462 17 6.70096104224861 GMNN CDT1 GO:0051052 BP regulation of DNA metabolic process 0.0701754385964912 0.220360834185905 57 9.6739225018382 PCNA GMNN KPNA2 BRCA1 RAD51 CDT1 GO:0051053 BP negative regulation of DNA metabolic process 0.0681818181818182 0.233781264548038 22 5.82445800527248 GMNN CDT1 GO:0000085 BP G2 phase of mitotic cell cycle 0.1 0.223606797749979 5 4.13580694501257 KPNA2 GO:0000724 BP double-strand break repair via homologous recombination 0.0769230769230769 0.187766904049703 13 5.0788943275622 BRCA1 RAD51 GO:0000725 BP recombinational repair 0.0769230769230769 0.187766904049703 13 5.0788943275622 BRCA1 RAD51 GO:0031572 BP G2/M transition DNA damage checkpoint 0.1 0.223606797749979 5 4.13580694501257 CCNA2 GO:0031576 BP G2/M transition checkpoint 0.1 0.223606797749979 5 4.13580694501257 CCNA2 GO:0051319 BP G2 phase 0.1 0.223606797749979 5 4.13580694501257 KPNA2 GO:0031398 BP positive regulation of protein ubiquitination 0.1 0.223606797749979 5 4.13580694501257 BRCA1 GO:0045739 BP positive regulation of DNA repair 0.125 0.25 4 4.65520952205131 BRCA1 GO:0051054 BP positive regulation of DNA metabolic process 0.0714285714285714 0.181568259800641 14 4.87751953935726 BRCA1 RAD51 GO:0051055 BP negative regulation of lipid biosynthetic process 0.125 0.25 4 4.65520952205131 BRCA1 GO:0033205 BP cytokinesis during cell cycle 0.2 0.447213595499958 5 8.41196627607269 RACGAP1 GO:0007051 BP spindle organization and biogenesis 0.157894736842105 0.374634324632678 19 12.8938435590593 ZWINT CKS2 TTK GO:0006270 BP DNA replication initiation 0.0555555555555556 0.160128153805087 27 5.19795989080066 MCM5 MCM6 CDT1 GO:0006364 BP rRNA processing 0.03125 0.175368093603050 64 4.28674348837155 EXOSC8 NOP5/NOP58 GO:0016072 BP rRNA metabolic process 0.0298507462686567 0.171459797720291 67 4.1670209300732 EXOSC8 NOP5/NOP58 GO:0000070 BP mitotic sister chromatid segregation 0.0517241379310345 0.204626296409494 29 4.99250636099438 ZWINT NCAPG GO:0000819 BP sister chromatid segregation 0.05 0.201288949968224 30 4.89727914024483 ZWINT NCAPG GO:0051383 BP kinetochore organization and biogenesis 0.25 0.5 4 9.43595007159814 MIS12 GO:0007052 BP mitotic spindle organization and biogenesis 0.090909090909091 0.301511344577764 11 5.5588488801078 TTK GO:0006699 BP bile acid biosynthetic process 0.1 0.223606797749979 5 4.13580694501257 CYP7B1 GO:0001522 BP pseudouridine synthesis 0.0714285714285714 0.267261241912424 14 4.87751953935726 PUS3 GO:0006400 BP tRNA modification 0.0769230769230769 0.277350098112615 13 5.0788943275622 PUS3 GO:0031119 BP tRNA pseudouridine synthesis 0.166666666666667 0.408248290463863 6 7.65365637502761 PUS3 GO:0008272 BP sulfate transport 0.0714285714285714 0.267261241912424 14 4.87751953935726 RACGAP1 GO:0009186 BP deoxyribonucleoside diphosphate metabolic process 0.125 0.25 4 4.65520952205131 RRM2 GO:0032392 BP DNA geometric change 0.0714285714285714 0.181568259800641 14 4.87751953935726 MCM6 RAD51 GO:0032508 BP DNA duplex unwinding 0.0714285714285714 0.181568259800641 14 4.87751953935726 MCM6 RAD51 GO:0006558 BP L-phenylalanine metabolic process 0.111111111111111 0.333333333333333 9 6.18700081393101 GCH1 GO:0006559 BP L-phenylalanine catabolic process 0.111111111111111 0.333333333333333 9 6.18700081393101 GCH1 GO:0009074 BP aromatic amino acid family catabolic process 0.0833333333333333 0.288675134594813 12 5.30423727647624 GCH1 GO:0042558 BP pteridine and derivative metabolic process 0.0666666666666667 0.258198889747161 15 4.69606878439463 GCH1 GO:0006729 BP tetrahydrobiopterin biosynthetic process 0.166666666666667 0.408248290463863 6 7.65365637502761 GCH1 GO:0019438 BP aromatic compound biosynthetic process 0.0769230769230769 0.277350098112615 13 5.0788943275622 GCH1 GO:0042559 BP pteridine and derivative biosynthetic process 0.0833333333333333 0.288675134594813 12 5.30423727647624 GCH1 GO:0046146 BP tetrahydrobiopterin metabolic process 0.142857142857143 0.377964473009227 7 7.06240725178827 GCH1 GO:0016584 BP nucleosome positioning 0.2 0.447213595499958 5 8.41196627607269 HIST1H1C GO:0006268 BP DNA unwinding during replication 0.0833333333333333 0.194624736040381 12 5.30423727647624 MCM6 RAD51 GO:0005634 CC nucleus 0.00676779463243874 0.0760910892584209 4285 5.10774448127609 RPS6KA5 DEK PCNA RPA2 PTTG1 ZWINT ITGB3BP MPHOSPH1 HIST1H1C CCNB1 EXOSC8 HJURP ORC6L PUS3 MIS12 RACGAP1 NOP5/NOP58 ZNF607 C15orf23 C6orf173 FANK1 KPNA2 CSE1L MCM5 MCM6 KIAA0101 CCNA2 BRCA1 RAD51 PSMC3IP SP4 LOC81691 RPA3 CDT1 NCAPG MLF1IP CDCA7 GO:0043228 CC non-membrane-bound organelle 0.00943396226415094 0.0910213182753135 1643 5.03608126528938 PCNA RPA2 ZWINT TTK ITGB3BP MPHOSPH1 HIST1H1C CCNB1 ORC6L MIS12 RACGAP1 NOP5/NOP58 BRCA1 RAD51 LOC81691 RPA3 CDT1 MLF1IP FAM33A GO:0043232 CC intracellular non-membrane-bound organelle 0.00943396226415094 0.0910213182753135 1643 5.03608126528938 PCNA RPA2 ZWINT TTK ITGB3BP MPHOSPH1 HIST1H1C CCNB1 ORC6L MIS12 RACGAP1 NOP5/NOP58 BRCA1 RAD51 LOC81691 RPA3 CDT1 MLF1IP FAM33A GO:0005819 CC spindle 0.0342465753424658 0.173380745184143 73 5.07022064442345 TTK RACGAP1 FAM33A GO:0000775 CC chromosome, pericentric region 0.0472972972972973 0.205555027444390 74 7.25662080822057 ZWINT ITGB3BP MIS12 MLF1IP GO:0000776 CC kinetochore 0.064516129032258 0.249731038114707 31 6.52527124587881 ZWINT MIS12 GO:0005694 CC chromosome 0.0266272189349112 0.151749002407622 338 8.29536724623102 PCNA RPA2 ZWINT ITGB3BP HIST1H1C ORC6L MIS12 RAD51 RPA3 CDT1 MLF1IP GO:0044427 CC chromosomal part 0.0301418439716312 0.163304339228394 282 8.70211849917552 PCNA RPA2 ZWINT ITGB3BP HIST1H1C ORC6L MIS12 RPA3 CDT1 MLF1IP GO:0000228 CC nuclear chromosome 0.032258064516129 0.161623078906893 93 5.3586642107494 RPA2 ORC6L RAD51 RPA3 GO:0044454 CC nuclear chromosome part 0.0390625 0.184835566133622 64 5.48419882877409 RPA2 ORC6L RPA3 GO:0000307 CC cyclin-dependent protein kinase holoenzyme complex 0.125 0.353553390593274 8 6.58429189674531 PCNA GO:0005657 CC replication fork 0.1 0.275430697209874 30 10.1386216666853 PCNA RPA2 RPA3 CDT1 GO:0000931 CC gamma-tubulin large complex 0.125 0.25 4 4.65520952205131 BRCA1 GO:0008274 CC gamma-tubulin ring complex 0.125 0.25 4 4.65520952205131 BRCA1 GO:0000777 CC condensed chromosome kinetochore 0.125 0.353553390593274 8 6.58429189674531 MIS12 GO:0000779 CC condensed chromosome, pericentric region 0.111111111111111 0.333333333333333 9 6.18700081393101 MIS12 GO:0045120 CC pronucleus 0.1 0.223606797749979 5 4.13580694501257 CCNA2 GO:0005652 CC nuclear lamina 0.25 0.5 4 9.43595007159814 PCNA GO:0000808 CC origin recognition complex 0.166666666666667 0.408248290463863 6 7.65365637502761 ORC6L GO:0005664 CC nuclear origin of replication recognition complex 0.166666666666667 0.408248290463863 6 7.65365637502761 ORC6L GO:0030894 CC replisome 0.107142857142857 0.28946711176092 14 7.43373991851826 RPA2 RPA3 GO:0043596 CC nuclear replication fork 0.09375 0.271952814534679 16 6.9226716558805 RPA2 RPA3 GO:0043601 CC nuclear replisome 0.107142857142857 0.28946711176092 14 7.43373991851826 RPA2 RPA3 GO:0005663 CC DNA replication factor C complex 0.166666666666667 0.408248290463863 6 7.65365637502761 PCNA GO:0000178 CC exosome (RNase complex) 0.090909090909091 0.301511344577764 11 5.5588488801078 EXOSC8 GO:0005662 CC DNA replication factor A complex 0.25 0.418330013267038 6 11.5573611573843 RPA2 RPA3 GO:0005732 CC small nucleolar ribonucleoprotein complex 0.0666666666666667 0.258198889747161 15 4.69606878439463 NOP5/NOP58 GO:0000444 CC MIS12/MIND type complex 0.25 0.5 4 9.43595007159814 MIS12 GO:0008022 MF protein C-terminus binding 0.0301204819277108 0.162851825333335 83 4.68742776987111 ITGB3BP RACGAP1 RAD51 GO:0043566 MF structure-specific DNA binding 0.0271739130434783 0.135956732669428 92 4.39446553618094 RPA2 MCM6 RAD51 RPA3 GO:0016725 MF oxidoreductase activity, acting on CH or CH2 groups 0.142857142857143 0.243975018237133 7 7.06240725178827 RRM1 RRM2 GO:0019238 MF cyclohydrolase activity 0.2 0.447213595499958 5 8.41196627607269 GCH1 GO:0032404 MF mismatch repair complex binding 0.125 0.353553390593274 8 6.58429189674531 PCNA GO:0032405 MF MutLalpha complex binding 0.166666666666667 0.408248290463863 6 7.65365637502761 PCNA GO:0016538 MF cyclin-dependent protein kinase regulator activity 0.166666666666667 0.408248290463863 6 7.65365637502761 CKS2 GO:0003697 MF single-stranded DNA binding 0.0531914893617021 0.187490363612996 47 6.55202793873428 RPA2 MCM6 RAD51 RPA3 GO:0016646 MF oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0.0526315789473684 0.229415733870562 19 4.11546907178241 DHFR GO:0043015 MF gamma-tubulin binding 0.142857142857143 0.377964473009227 7 7.06240725178827 RACGAP1 GO:0042393 MF histone binding 0.0714285714285714 0.267261241912424 14 4.87751953935726 DEK GO:0016439 MF tRNA-pseudouridine synthase activity 0.0526315789473684 0.229415733870562 19 4.11546907178241 PUS3 GO:0016796 MF exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0526315789473684 0.229415733870562 19 4.11546907178241 EXOSC8 GO:0016670 MF oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor 0.1 0.223606797749979 5 4.13580694501257 SUOX GO:0000175 MF 3'-5'-exoribonuclease activity 0.111111111111111 0.333333333333333 9 6.18700081393101 EXOSC8 GO:0004532 MF exoribonuclease activity 0.0833333333333333 0.288675134594813 12 5.30423727647624 EXOSC8 GO:0016896 MF exoribonuclease activity, producing 5'-phosphomonoesters 0.0833333333333333 0.288675134594813 12 5.30423727647624 EXOSC8 GO:0004295 MF trypsin activity 0.142857142857143 0.377964473009227 7 7.06240725178827 PRSS2 GO:0004748 MF ribonucleoside-diphosphate reductase activity 0.25 0.288675134594813 4 9.43595007159814 RRM1 RRM2 GO:0016728 MF oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 0.25 0.288675134594813 4 9.43595007159814 RRM1 RRM2 GO:0048487 MF beta-tubulin binding 0.1 0.316227766016838 10 5.84983773231588 RACGAP1 GO:0050699 MF WW domain binding 0.166666666666667 0.408248290463863 6 7.65365637502761 MPHOSPH1