GOname GO GO.term set.means set.sd n.genes z.score lead.genes GO:0006800 BP oxygen and reactive oxygen species metabolic process 0.0853658536585366 0.271625639078637 41 5.48323385651339 GPX3 EPHX2 FMO2 ALOX12 GO:0008236 MF serine-type peptidase activity 0.050314465408805 0.211945244253273 159 5.84684457719448 CFD PRSS2 KLK13 PRSS3 DKFZP586H2123 TMPRSS11E PRSS27 DPP4 KLK10 GO:0006534 BP cysteine metabolic process 0.166666666666667 0.408248290463863 6 4.33346626839115 CBS GO:0006690 BP icosanoid metabolic process 0.073170731707317 0.238772266232809 41 4.6046615716715 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0006691 BP leukotriene metabolic process 0.136363636363636 0.315542547950509 22 6.70388571895359 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0030574 BP collagen catabolic process 0.1 0.307793505625546 20 4.56299957764509 MMP1 PRSS2 GO:0043616 BP keratinocyte proliferation 0.375 0.478713553878169 4 8.22061724909825 KRT2 EREG GO:0004301 MF epoxide hydrolase activity 0.25 0.5 4 5.41107033785137 EPHX2 GO:0031424 BP keratinization 0.181818181818182 0.394771016975861 22 9.10122535559707 LOR KRT2 IVL LCE3D GO:0009395 BP phospholipid catabolic process 0.115384615384615 0.299572344757639 13 4.30155996669694 PLA2G4F PLA2G4C GO:0008544 BP epidermis development 0.0625 0.238715927658058 120 6.5787804722896 CRABP2 COL17A1 ALOX12B LOR KRT2 IVL LCE3D CST6 GO:0016165 MF lipoxygenase activity 0.285714285714286 0.393397896234722 7 8.2208535059328 ALOX12B ALOX15B ALOX12 GO:0046456 BP icosanoid biosynthetic process 0.103448275862069 0.279646152205514 29 5.70497917589202 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0004175 MF endopeptidase activity 0.0279329608938547 0.160711568900075 358 4.01628743725843 MMEL1 MMP1 CFD PRSS2 KLK13 PRSS3 DKFZP586H2123 TMPRSS11E PRSS27 DPP4 KLK10 GO:0004179 MF membrane alanyl aminopeptidase activity 0.136363636363636 0.323334895341432 11 4.73873123208007 RNPEPL1 TRHDE GO:0004126 MF cytidine deaminase activity 0.166666666666667 0.408248290463863 6 4.33346626839115 CDA GO:0016116 BP carotenoid metabolic process 0.2 0.447213595499958 5 4.79344289657212 BCDO2 GO:0016108 BP tetraterpenoid metabolic process 0.2 0.447213595499958 5 4.79344289657212 BCDO2 GO:0016290 MF palmitoyl-CoA hydrolase activity 0.2 0.447213595499958 5 4.79344289657212 ACOT2 GO:0004295 MF trypsin activity 0.285714285714286 0.487950036474267 7 8.2208535059328 PRSS2 PRSS3 GO:0004252 MF serine-type endopeptidase activity 0.0555555555555556 0.222125075890925 144 6.27150471589473 CFD PRSS2 KLK13 PRSS3 DKFZP586H2123 TMPRSS11E PRSS27 DPP4 KLK10 GO:0016284 MF alanine aminopeptidase activity 0.136363636363636 0.323334895341432 11 4.73873123208007 RNPEPL1 TRHDE GO:0018149 BP peptide cross-linking 0.111111111111111 0.323380833381777 18 4.85857583277953 LOR IVL GO:0016801 MF hydrolase activity, acting on ether bonds 0.166666666666667 0.353553390593274 9 5.30788869244851 EPHX2 ALOX12 GO:0016803 MF ether hydrolase activity 0.25 0.418330013267038 6 6.62759521952148 EPHX2 ALOX12 GO:0009898 CC internal side of plasma membrane 0.166666666666667 0.408248290463863 6 4.33346626839115 LOR GO:0016559 BP peroxisome fission 0.25 0.5 4 5.41107033785137 PEX11G GO:0042312 BP regulation of vasodilation 0.166666666666667 0.408248290463863 6 4.33346626839115 EPHX2 GO:0048285 BP organelle fission 0.166666666666667 0.408248290463863 6 4.33346626839115 PEX11G GO:0031638 BP zymogen activation 0.25 0.5 4 5.41107033785137 PRSS3 GO:0016670 MF oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor 0.2 0.273861278752583 5 4.79344289657212 SUOX QSOX1 GO:0048729 BP tissue morphogenesis 0.0740740740740741 0.264350528572715 54 5.36135793673776 LOR KRT2 IVL LCE3D GO:0048730 BP epidermis morphogenesis 0.102564102564103 0.307354740604728 39 6.55582803587183 LOR KRT2 IVL LCE3D GO:0005152 MF interleukin-1 receptor antagonist activity 0.166666666666667 0.408248290463863 6 4.33346626839115 IL1F5 GO:0000271 BP polysaccharide biosynthetic process 0.0862068965517241 0.269555371903747 29 4.66072284016608 GYS2 B3GNT8 PPP1R3C GO:0007398 BP ectoderm development 0.0572519083969466 0.229055093927252 131 6.19833754252843 CRABP2 COL17A1 ALOX12B LOR KRT2 IVL LCE3D CST6 GO:0005149 MF interleukin-1 receptor binding 0.153846153846154 0.375533808099405 13 5.86045504720574 IL18 IL1F5 GO:0042104 BP positive regulation of activated T cell proliferation 0.166666666666667 0.408248290463863 6 4.33346626839115 IL18 GO:0019370 BP leukotriene biosynthetic process 0.166666666666667 0.342997170285018 18 7.50860264709079 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0033692 BP cellular polysaccharide biosynthetic process 0.0862068965517241 0.269555371903747 29 4.66072284016608 GYS2 B3GNT8 PPP1R3C GO:0042253 BP granulocyte macrophage colony-stimulating factor biosynthetic process 0.2 0.447213595499958 5 4.79344289657212 IL18 GO:0044421 CC extracellular region part 0.0237467018469657 0.145711751822654 758 4.59340632025915 RPTN FN1 GPX3 APOD SPOCK1 MFAP2 MMP1 COL17A1 PRSS2 IL18 PRSS3 CRISP3 CRISP2 SLURP1 IL1F5 A2ML1 EREG QSOX1 GPC4 CMTM8 SULF2 GO:0004992 MF platelet activating factor receptor activity 0.25 0.5 4 5.41107033785137 PDGFRL GO:0009913 BP epidermal cell differentiation 0.121212121212121 0.331433982639808 33 7.23433190271369 LOR KRT2 IVL LCE3D GO:0044266 BP multicellular organismal macromolecule catabolic process 0.1 0.307793505625546 20 4.56299957764509 MMP1 PRSS2 GO:0044268 BP multicellular organismal protein metabolic process 0.1 0.307793505625546 20 4.56299957764509 MMP1 PRSS2 GO:0044254 BP multicellular organismal protein catabolic process 0.1 0.307793505625546 20 4.56299957764509 MMP1 PRSS2 GO:0044256 BP protein digestion 0.1 0.307793505625546 20 4.56299957764509 MMP1 PRSS2 GO:0044259 BP multicellular organismal macromolecule metabolic process 0.1 0.307793505625546 20 4.56299957764509 MMP1 PRSS2 GO:0044243 BP multicellular organismal catabolic process 0.090909090909091 0.29424494316825 22 4.3065460823101 MMP1 PRSS2 GO:0044236 BP multicellular organismal metabolic process 0.0833333333333333 0.28232985128664 24 4.08097298311906 MMP1 PRSS2 GO:0042573 BP retinoic acid metabolic process 0.25 0.5 4 5.41107033785137 BCDO2 GO:0005576 CC extracellular region 0.0228873239436620 0.143579347358123 1704 6.68971125338973 MMEL1 RPTN FN1 GPX3 APOD SPOCK1 NELL2 MFAP2 ACPP MMP1 COL17A1 PDGFRL CFD PRSS2 CDA KLK13 IL18 SPINK2 PRSS3 CRISP3 ESM1 CRISP2 SOSTDC1 DKFZP586H2123 SLURP1 TMPRSS11E IL1F5 SPINK7 FAM3D RSPO3 PRSS27 SBSN SFTPG A2ML1 EREG QSOX1 STC2 DPP4 GPC4 CST6 KLK10 GFOD2 CMTM8 EPDR1 SULF2 GO:0005501 MF retinoid binding 0.142857142857143 0.363136519601281 14 5.61964551189618 APOD CRABP2 GO:0005678 CC chromatin assembly complex 0.166666666666667 0.408248290463863 6 4.33346626839115 NAP1L2 GO:0005626 CC insoluble fraction 0.1 0.307793505625546 20 4.56299957764509 LOR GYS2 GO:0005615 CC extracellular space 0.025 0.148050118795463 500 4.01940735900787 GPX3 APOD SPOCK1 MMP1 PRSS2 IL18 PRSS3 CRISP2 SLURP1 IL1F5 A2ML1 EREG QSOX1 CMTM8 SULF2 GO:0010467 BP gene expression 0.00319081046585833 0.0504309291334129 3134 -4.25448467808392 FLJ14959 EREG PIAS3 TFCP2 KHDRBS3 ZSCAN18 MGC21874 SIX4 CRABP2 NAT14 GLIS2 ZNF607 TCEAL7 LOC134466 GO:0019840 MF isoprenoid binding 0.142857142857143 0.363136519601281 14 5.61964551189618 APOD CRABP2 GO:0055038 CC recycling endosome membrane 0.166666666666667 0.408248290463863 6 4.33346626839115 RAB11FIP5 GO:0010224 BP response to UV-B 0.166666666666667 0.408248290463863 6 4.33346626839115 IVL GO:0001882 MF nucleoside binding 0.2 0.447213595499958 5 4.79344289657212 CDA GO:0015280 MF amiloride-sensitive sodium channel activity 0.1875 0.372011904571422 8 5.66646831459463 SCNN1B SCNN1G GO:0001527 CC microfibril 0.25 0.5 4 5.41107033785137 MFAP2 GO:0001517 MF N-acetylglucosamine 6-O-sulfotransferase activity 0.2 0.447213595499958 5 4.79344289657212 CHST2 GO:0001533 CC cornified envelope 0.15625 0.352077169571293 16 6.61030165338434 LOR IVL CST6 GO:0017171 MF serine hydrolase activity 0.05 0.211315139188640 160 5.82046536756554 CFD PRSS2 KLK13 PRSS3 DKFZP586H2123 TMPRSS11E PRSS27 DPP4 KLK10 GO:0045793 BP positive regulation of cell size 0.1875 0.372011904571422 8 5.66646831459463 PRSS2 ALOX12 GO:0017144 BP drug metabolic process 0.166666666666667 0.408248290463863 6 4.33346626839115 EPHX2 GO:0045785 BP positive regulation of cell adhesion 0.107142857142857 0.28946711176092 14 4.1174096145252 PRSS2 ALOX12 GO:0008035 MF high-density lipoprotein binding 0.25 0.5 4 5.41107033785137 APOD GO:0043450 BP alkene biosynthetic process 0.166666666666667 0.342997170285018 18 7.50860264709079 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0030353 MF fibroblast growth factor receptor antagonist activity 0.166666666666667 0.408248290463863 6 4.33346626839115 IL1F5 GO:0032604 BP granulocyte macrophage colony-stimulating factor production 0.2 0.447213595499958 5 4.79344289657212 IL18 GO:0043449 BP alkene metabolic process 0.136363636363636 0.315542547950509 22 6.70388571895359 ALOX12B RNPEPL1 ALOX15B ALOX12 GO:0030307 BP positive regulation of cell growth 0.214285714285714 0.393397896234722 7 6.09683637264624 PRSS2 ALOX12 GO:0002028 BP regulation of sodium ion transport 0.25 0.5 4 5.41107033785137 SCNN1B GO:0030431 BP sleep 0.2 0.447213595499958 5 4.79344289657212 IL18 GO:0006139 BP nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 0.00325443786982249 0.0515064599235835 3380 -4.414384963809 FLJ14959 EREG PIAS3 TFCP2 KHDRBS3 ZSCAN18 MGC21874 SIX4 CRABP2 CDA NAT14 GLIS2 ZNF607 TCEAL7 LOC134466 GO:0045980 BP negative regulation of nucleotide metabolic process 0.2 0.447213595499958 5 4.79344289657212 CDA GO:0045909 BP positive regulation of vasodilation 0.25 0.5 4 5.41107033785137 EPHX2 GO:0051262 BP protein tetramerization 0.111111111111111 0.323380833381777 18 4.85857583277953 GPX3 CDA GO:0032963 BP collagen metabolic process 0.090909090909091 0.29424494316825 22 4.3065460823101 MMP1 PRSS2 GO:0051259 BP protein oligomerization 0.0583333333333333 0.227209801252742 60 4.27978404855018 GPX3 CDA UPK1A AMFR GO:0043205 CC fibril 0.166666666666667 0.408248290463863 6 4.33346626839115 MFAP2 GO:0051289 BP protein homotetramerization 0.222222222222222 0.440958551844098 9 7.18121293445218 GPX3 CDA GO:0006790 BP sulfur metabolic process 0.0506329113924051 0.205609424183839 79 4.1428320738741 CBS GPX3 CHST2 SUOX SULF2 GO:0030280 MF structural constituent of epidermis 0.15 0.337474278855276 10 5.00276531979723 LOR PKP1 GO:0030216 BP keratinocyte differentiation 0.0961538461538462 0.283521807599725 26 4.98304672424055 LOR IVL EREG GO:0008131 MF amine oxidase activity 0.2 0.447213595499958 5 4.79344289657212 AOC3 GO:0008133 MF collagenase activity 0.2 0.447213595499958 5 4.79344289657212 MMP1