News

2023.11.07
Manuscript submitted: "Detectability of Varied Hybridization Scenarios Using Genome-Scale Hybrid Detection Methods"
2023.07.14
Manuscript submitted: "Infection induced inflammation impairs wound healing through IL-1β signaling"
2023.02.20
Paper published in Blood Advances: "RNA-Regulatory Exosome Complex Suppresses an Apoptotic Program to Confer Erythroid Progenitor Cell Survival in Vivo"
2023.02.01
Paper published in Computational Biology and Chemistry: "A Nile Rat Transcriptomic Landscape across 22 Organs by Ultra-Deep Sequencing and Comparative RNA-Seq Pipeline (CRSP)"
2022.09.16
Paper published in iScience: "Distinctive Populations of CD4+T Cells Associated with Vaccine Efficacy"
2022.02.16
Paper published in Front Immunol: "Cell Type-Specific Transcriptome Profiling Reveals a Role for Thioredoxin During Tumor Initiation"
2021.06.01
Paper published in Nucleic Acids Research: "RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis"
2021.09.17
Paper published in STAR Protocols: "Annotating cell types in human single-cell RNA-seq data with CellO"
2021.01.22
Paper published in iScience: "CellO: Comprehensive and hierarchical cell type classification of human cells with the Cell Ontology"
2021.01.01
Paper published in Molecular Cancer Therapeutics: "PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways"
2020.09.21
Paper published in Genome Research: "PRAM: a novel pooling approach for discovering intergenic transcripts from large-scale RNA sequencing experiments"
2020.07.10
Manuscript submitted: "CellO: Comprehensive and hierarchical cell type classification of human cells with the Cell Ontology"
2020.06.12
Paper published in Genome Biology and Evolution: "Giant Island Mice Exhibit Widespread Gene Expression Changes in Key Metabolic Organs"
2019.12.12
Manuscript submitted: "Cell type specific gene expression profiling reveals a role for the complement component C3A in neutrophil migration to tissue damage"
2019.07.06
Book chapter published in Evolutionary Genomics: "Whole-genome alignment"
2019.05.13
Manuscript submitted: "PRAM: a novel pooling approach for discovering intergenic transcripts from large-scale RNA sequencing experiments"
2019.04.23
Paper published in PNAS: "Genome-wide effects on Escherichia coli transcription from ppGpp binding to its two sites on RNA polymerase"
2018.07.01
Promoted to Professor!
2017.08.07
Paper published in Developmental Cell: "GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia"
2017.07.06
Paper published in Developmental Biology: "Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis"
2017.05.23
Paper published in Bioinformatics: "MetaSRA: normalized human sample-specific metadata for the Sequence Read Archive"
2016.07.27
Paper published in Developmental Biology: "Analysis of embryonic development in the unsequenced axolotl: Waves of transcriptomic upheaval and stability"
2016.07.12
Paper published in Genome Research: "Integrative analysis with ChIP-seq advances the limits of transcript quantification from RNA-seq"
2016.01.06
Named a Vilas Associate
2015.12.16
Group member Nathanael Fillmore successfully defends his PhD thesis: "Generative models for transcriptome assembly and analysis"
2015.12.23
Paper published in EMBO Reports: "Mechanism Governing Heme Synthesis Reveals a GATA Factor-Heme Circuit that Controls Differentiation"
2015.10.20
Paper published in PLoS Computational Biology: "Perm-seq: Mapping protein-DNA interactions in segmental duplication and highly repetitive regions of genomes with prior-enhanced read mapping"
2015.09.04
Paper published in Science Advances: "Cis-regulatory mechanisms governing stem and progenitor cell transitions"
2015.07.02
Paper published in Molecular Cell: "Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome"
2015.04.20
Grant awarded by NIH: "Integrated biochemical and bioinformatic technologies for accurate transcriptome-wide full-length RNA assembly." (Co-PI w/ M. Lodes, Lucigen)
2015.04.05
Paper published in Bioinformatics: "EBSeq-HMM: a Bayesian approach for identifying gene-expression changes in ordered RNA-seq experiments"
2014.12.21
Paper published in Genome Biology: "Evaluation of de novo transcriptome assemblies from RNA-Seq data"
2014.09.29
Grant awarded by NIH: "The Center for Predictive Computational Phenotyping." (Project lead w/ M. Craven, Director)
2013.12.02
Paper published in Journal of Experimental Medicine: "Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo"
2013.09.23
Paper published in RNA: "Bicaudal-C spatially controls translation of vertebrate maternal mRNAs"
2013.07.11
Paper published in Bioinformatics: "Inference of alternative splicing from RNA-Seq data with probabilistic splice graphs"
2013.07.11
Paper published in Nature Protocols: "De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis"
2013.07.05
Grant awarded by NIH: "Defining the Xenopus translatome." (Co-investigator w/ M. Sheets (PI))
2013.03.07
Paper published in PLoS Computational Biology: "Comparative RNA-seq analysis in the unsequenced axolotl: The oncogene burst highlights early gene expression in the blastema"
2013.01.09
Paper published in Nucleic Acids Research: "Rbm20 regulates titin alternative splicing as a splicing repressor"
2012.10.01
Paper published in Genetics: "Genomic variation in natural populations of Drosophila melanogaster"
2012.09.17
Grant awarded by NIH: "Statistical methods for annotating repetitive genomic regions through ENCODE-derived data." (Co-PI w/ S. Keles (PI) and E. Bresnick)
2012.09.10
Grant awarded by NIH: "The genetics and evolution of extreme body size in mice from Gough Island." (Co-investigator w/ B. Payseur (PI) and K. Broman)
2012.07.01
Promoted to Associate Professor with tenure!
2012.03.12
Book chapter published in Evolutionary Genomics : "Whole-Genome Alignment"
2011.11.23
Paper published in IEEE transactions on visualization and computer graphics : "Sequence Surveyor: leveraging overview for scalable genomic alignment visualization"
2011.09.23
RSEM paper acquires designation of "Highly accessed"
2011.08.04
Paper published in BMC Bioinformatics: "RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome"
2011.07.14
Paper published in PLoS Computational Biology: "Discovering transcription factor binding sites in highly repetitive regions of genomes with multi-read analysis of ChIP-seq data"
2011.06.24
Paper published in Briefings in Bioinformatics: "Positional orthology: putting genomic evolutionary relationships into context".
2010.09.21
Paper published in Bioinformatics: "BUCKy: Gene Tree / Species Tree Reconciliation with Bayesian Concordance Analysis".
2010.06.30
Grant awarded by NIH: "Computational methods for the analysis of RNA-Seq data."
2010.04.27
Grant awarded by WisCID: "Small RNAs of the human intestinal microbiome." (Co-PI w/ H. Goodrich-Blair, N. Safdar, and J. Sonnenburg)
2009.12.18
Paper published in Bioinformatics: "RNA-Seq gene expression estimation with read mapping uncertainty".
2009.12.15
Paper accepted in Bioinformatics: "RNA-Seq gene expression estimation with read mapping uncertainty".
2009.11.20
Paper published in PLoS Genetics: "Fine scale phylogenetic discordance across the house mouse genome".
2009.05.29
Paper published in PLoS Computational Biology: "Fast Statistical Alignment".
2009.03.28
Paper accepted in PLoS Computational Biology: "Fast Statistical Alignment".
2008.12.03
Teaching Science Masters Institute course on "Genetics, Natural Selection & Evolution" July 13-16, 2009.
2008.05.13
Teaching BMI/CS 576 "Advanced Bioinformatics" during the Fall 2008 semester.
2008.05.13
Teaching Science Masters Institute course on "Genetics, Natural Selection & Evolution" June 23-26, 2008.
2008.01.22
Teaching BMI/CS 776 "Advanced Bioinformatics" during the Spring 2008 semester.
2007.11.12
Teaching Science Masters Institute course on "Natural Selection & Evolution" Nov 12, 17, 26, & Dec 1
2007.11.08
Paper published in Nature: "Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures"
2007.11.06
Paper published in PLoS Biology: "Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans"
2007.06.14
ENCODE pilot project results in the media: BBC, Boston Globe, Washington Post
2007.06.14
Paper published in Genome Research: "Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome"
2007.06.14
Paper published in Nature: "Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project"
2007.06.07
Joined UW Comprehensive Cancer Center as member.
2007.01.23
Teaching BMI/CS 776 "Advanced Bioinformatics" during the Spring 2007 semester.
2006.12.08
Paper published in BMC Genomics: "Compensatory relationships between splice sites and exonic splicing signals depending on the length of vertebrate introns"
2006.11.22
Joined the Computation and Informatics in Biology and Medicine program as faculty trainer.
2006.09.22
Joined the Genomic Sciences Training Program as faculty trainer.
2006.08.09
Joined the Computer Sciences Department as affiliate faculty member.
2006.08.01
Joined the Genome Center of Wisconsin as member.
2006.08.01
Joined the Biostatistics and Medical Informatics Department as assistant professor.
RSS Feed
UW Crest
UW Biostatistics & Medical Informatics Computer Sciences CGSI
Design