Biostat 140.668

Problem set 4: Interval mapping

  1. Implement (in R) the EM algorithm for interval mapping with a single-QTL model, under the assumption that the residual variation is homoscedastic and normally distributed, for a backcross. Consider just one pair of markers at a recombination fraction, r; assuming complete data at the markers and no crossover interference.
  2. Try out the R/qtl software. Follow along the tutorial. You might even look at the code.


Course syllabus

Last modified: Wed Nov 6 15:22:48 EST 2002