| Instructors: | Karl Broman and Giovanni Parmigiani | |
| Office hours: | KB: W 1:00-2:00 in E3612 Hygiene GP: Monday after class in E3136 Hygiene | |
| Topics: | Linkage mapping in model organisms (KB); Characterization of cancer genes (GP) | |
| Prerequisites: | 140.651-654; knowledge of the computer package R. | |
| Course time: | Monday and Wednesday, 10:30am - noon | |
| Course room: | W3031 Hygiene | |
| Grades: | Student grades will be based on a single project, including an short oral presentation, on a topic related to either half of the course. |
| Date | Instructor | R | P | S | Topic | |
| Oct | 28 | KB |
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| Meiosis, recombination, interference |
| 30 | KB |
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| Hidden Markov models | |
| Nov | 4 | KB |
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| Constructing linkage maps |
| 6 | KB |
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| QTL mapping: interval mapping | |
| 11 | KB |
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| QTL mapping: other single-QTL models | |
| 13 | KB |
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| Recombinant inbred lines | |
| 18 | GP |
| Fundamentals of genetic risk predition in familial syndromes: The BRCAPRO and CRCAPRO models | |||
| 20 | GP |
| Validation of risk prediction models | |||
| 25 | GP |
| Penetrance estimation and ascertainment corrections | |||
| 27 | GP |
| Population-Calibrated Gene Characterization (Sining Chen presenting) | |||
| Dec | 2 | GP |
| Penetrance estimation using the kindred-cohort design | ||
| 4 | KB |
| Mapping multiple QTL I | |||
| 9 | GP |
| Classification of missense mutations of disease genes | |||
| 11 | KB |
| Mapping multiple QTL II | |||
| 16 | KB & GP | Student presentations of research projects | ||||
| 18 | KB & GP | Student presentations of research projects | ||||
R = References; P = Problems; S = Solutions
Last modified: Wed Apr 15 23:09:54 2009 |